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SRX3177 {[allProObj[0].p_purity_real_show]}

货号:A1951779 Ambeed 开学季,买赠积分,赢豪礼

SRX3177CDK4/6、PI3K 和 BRD4 的三重抑制剂,IC50 值分别为 33 nM (BRD4 BD1)、89 nM (BRD4 BD2)、79 nM (PI3Kα)、83 nM (PI3Kδ)、3.18 μM (PI3Kγ)、<2.5 nM (CDK4)、3.3 nM (CDK6),对癌细胞具有广泛的细胞毒性,但对正常上皮细胞无害。

SRX3177 化学结构 CAS号:2241237-51-2
SRX3177 化学结构
CAS号:2241237-51-2
SRX3177 3D分子结构
CAS号:2241237-51-2
SRX3177 化学结构 CAS号:2241237-51-2
SRX3177 3D分子结构 CAS号:2241237-51-2
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SRX3177 纯度/质量文件 产品仅供科研

货号:A1951779 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 BET bromodomain BRPF CBP/beta-catenin p300/CBP 其他靶点 纯度
MS436 ++

BRD4 (2), Ki: 0.34 μM

BRD4 (1), Ki: <0.085 μM

{[allProObj[0].p_purity_real_show]}
CPI-203 +++

BRD4, IC50: 37 nM

{[allProObj[0].p_purity_real_show]}
GSK1324726A +++

BRD2, IC50: 31 nM

BRD4, IC50: 22 nM

{[allProObj[0].p_purity_real_show]}
PFI-1 ++

BRD2, IC50: 98 nM

BRD4, IC50: 0.22 μM

{[allProObj[0].p_purity_real_show]}
Apabetalone +

BD2, IC50: 0.51 μM

{[allProObj[0].p_purity_real_show]}
(+)-JQ1 +++

BRD4 (1), IC50: 77 nM

BRD4 (2), IC50: 33 nM

{[allProObj[0].p_purity_real_show]}
I-BET151 +

BRD3, IC50: 0.25 μM

BRD4, IC50: 0.5 μM

{[allProObj[0].p_purity_real_show]}
Molibresib +++

BET proteins, IC50: 35 nM

{[allProObj[0].p_purity_real_show]}
I-BRD9 +++

BRD9, pIC50: 7.3

BRD4, pIC50: 5.3

{[allProObj[0].p_purity_real_show]}
BI-7273 ++++

BRD7, IC50: 117 nM

BRD9, IC50: 19 nM

{[allProObj[0].p_purity_real_show]}
Pelabresib +++

BRD4-BD1, IC50: 39 nM

{[allProObj[0].p_purity_real_show]}
ARV-825 +++

BRD4 BD2, Kd: 28 nM

BRD4 BD1, Kd: 90 nM

{[allProObj[0].p_purity_real_show]}
Birabresib {[allProObj[0].p_purity_real_show]}
BI 2536 +++

BRD4, Kd: 37 nM

c-Myc {[allProObj[0].p_purity_real_show]}
Bromosporine ++

BRD2, IC50: 0.29 μM

BRD9, IC50: 0.122 μM

++++

CECR2, IC50: 17 nM

{[allProObj[0].p_purity_real_show]}
XMD8-92 ++

BRD4 (1), Kd: 170 nM

{[allProObj[0].p_purity_real_show]}
Mivebresib {[allProObj[0].p_purity_real_show]}
BI-9564 ++++

BRD9, Kd: 5.9 nM

BRD7, Kd: 73 nM

++

CECR2, Kd: 77 nM

{[allProObj[0].p_purity_real_show]}
AZD5153 6-Hydroxy-2-naphthoic acid ++++

FL-BRD4, IC50: 5 nM

{[allProObj[0].p_purity_real_show]}
PLX51107 ++++

BRD4 BD2, Kd: 1.7 nM

BRD3 BD1, Kd: 2.1 nM

{[allProObj[0].p_purity_real_show]}
FL-411 +

BRD4(1), IC50: 0.43 μM

{[allProObj[0].p_purity_real_show]}
ABBV-744 {[allProObj[0].p_purity_real_show]}
dBET6 ++++

BRD4, IC50: 14 nM

{[allProObj[0].p_purity_real_show]}
dBET1 ++++

BRD4, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
MZ1 ++++

Brd3(BD2), Kd: 13 nM

Brd2(BD2), Kd: 62 nM

{[allProObj[0].p_purity_real_show]}
dBET57 +

BRD4BD1, DC50: 500 nM

{[allProObj[0].p_purity_real_show]}
SF2523 +

BRD4, IC50: 241 nM

DNA-PK {[allProObj[0].p_purity_real_show]}
INCB054329 ++++

BRD3-BD1, IC50: 9 nM

BRD4-BD1, IC50: 119 nM

{[allProObj[0].p_purity_real_show]}
INCB-057643 {[allProObj[0].p_purity_real_show]}
(E/Z)-ZL0420 +++

BRD4 BD1, IC50: 27 nM

BRD4 BD2, IC50: 32 nM

{[allProObj[0].p_purity_real_show]}
BMS-986158 {[allProObj[0].p_purity_real_show]}
BRD4 Inhibitor-10 ++++

BRD4-BD2, IC50: 41 nM

BRD4-BD1, IC50: 5 nM

{[allProObj[0].p_purity_real_show]}
A1874 {[allProObj[0].p_purity_real_show]}
Y06036 ++

BRD4 (1), Kd: 82 nM

{[allProObj[0].p_purity_real_show]}
Alobresib NF-κB {[allProObj[0].p_purity_real_show]}
ODM-207 {[allProObj[0].p_purity_real_show]}
GSK778 +++

BRD2-BD1, IC50: 75nM

BRD4-BD1, IC50: 143 nM

{[allProObj[0].p_purity_real_show]}
SRX3207 +

BRD41, IC50: 3070 nM

BRD42, IC50: 3070 nM

Syk {[allProObj[0].p_purity_real_show]}
GSK046 +++

BRD4BD2, IC50: 214 nM

BRD3BD2, IC50: 98 nM

{[allProObj[0].p_purity_real_show]}
GSK620 {[allProObj[0].p_purity_real_show]}
Thalidomide-NH-C4-NH-Boc {[allProObj[0].p_purity_real_show]}
Trotabresib {[allProObj[0].p_purity_real_show]}
NHWD-870 {[allProObj[0].p_purity_real_show]}
CFT8634 ++++

BRD9, DC50: 3 nM

{[allProObj[0].p_purity_real_show]}
GSK2801 ++

BAZ2B, Kd: 136 nM

BAZ2A, Kd: 257 nM

{[allProObj[0].p_purity_real_show]}
KG-501 {[allProObj[0].p_purity_real_show]}
UNC 669 +

L3MBTL3, IC50: 35 μM

L3MBTL4, IC50: 6 μM

{[allProObj[0].p_purity_real_show]}
PFI-3 +++

SMARCA2A, Kd: 72 nM

SMARCA4, Kd: 55 nM

{[allProObj[0].p_purity_real_show]}
UNC1215 +++

L3MBTL3- D274A, IC50: 3.5 μM

L3MBTL3, IC50: 120 nM

{[allProObj[0].p_purity_real_show]}
EED226 ++

PRC2, Kd: 114 nM

EED, Kd: 82 nM

{[allProObj[0].p_purity_real_show]}
BRD9539 {[allProObj[0].p_purity_real_show]}
UNC926 +

L3MBTL1, Kd: 3.9 μM

{[allProObj[0].p_purity_real_show]}
666-15 ++

CREB, IC50: 81 nM

{[allProObj[0].p_purity_real_show]}
UNC6852 +

EED, IC50: 247 nM

{[allProObj[0].p_purity_real_show]}
BAZ1A-IN-1 +

BAZ1A, Kd: 0.52 μM

{[allProObj[0].p_purity_real_show]}
PFI-4 ++

BRPF2, IC50: 7.9 μM

BRPF1, IC50: 80 nM

{[allProObj[0].p_purity_real_show]}
OF-1 ++

BRPF2, Kd: 500 nM

BRPF1B, Kd: 100 nM

{[allProObj[0].p_purity_real_show]}
GSK-5959 ++

BRPF3, pIC50: 7.1

BRPF2, pIC50: 5.2

{[allProObj[0].p_purity_real_show]}
GSK6853 ++++

BRPF1, pIC50: 8.1

{[allProObj[0].p_purity_real_show]}
NI-42 ++++

BRPF1, IC50: 48 nM

BRPF3, IC50: 260 nM

{[allProObj[0].p_purity_real_show]}
E-7386 +++

CBP/beta-catenin, IC50: 0.0484 μM

{[allProObj[0].p_purity_real_show]}
I-CBP112 ++

p300, Kd: 167 nM

CBP, Kd: 151 nM

{[allProObj[0].p_purity_real_show]}
Histone Acetyltransferase Inhibitor II +

p300, IC50: 5 μM

{[allProObj[0].p_purity_real_show]}
C646 +

p300/CBP, Ki: 400 nM

{[allProObj[0].p_purity_real_show]}
Anacardic Acid +

p300/CBP, IC50: 8.5 μM

PCAF, IC50: 5 μM

{[allProObj[0].p_purity_real_show]}
SGC-CBP30 ++++

EP300, IC50: 38 nM

CREBBP, IC50: 21 nM

{[allProObj[0].p_purity_real_show]}
Nordihydroguaiaretic acid HER2,IGF-1R {[allProObj[0].p_purity_real_show]}
Curcumin +

p300, IC50: ~25 μM

Nrf2,Ferroptosis,NF-κB {[allProObj[0].p_purity_real_show]}
PF-CBP1 HCl ++

p300/CBP, IC50: 363nM

CREBBP, IC50: 125nM

{[allProObj[0].p_purity_real_show]}
CPI-637 +++

EP300, IC50: 0.051 μM

CBP, IC50: 0.03 μM

{[allProObj[0].p_purity_real_show]}
Foscenvivint β-catenin {[allProObj[0].p_purity_real_show]}
A-485 ++

p300 HAT, IC50: 0.06 μM

{[allProObj[0].p_purity_real_show]}
GNE-781 +

BRD4(1), IC50: 5100 nM

++++

CBP, IC50: 0.94 nM

{[allProObj[0].p_purity_real_show]}
NEO2734 +++

BET, IC50: <30 nM

+++

p300/CBP, IC50: <30 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 Cdc CDK1 CDK19 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CLK 其他靶点 纯度
XL413 hydrochloride ++++

Cdc7, IC50: 3.4 nM

{[allProObj[0].p_purity_real_show]}
SU9516 +++

CDK1, IC50: 40 nM

+++

CDK2, IC50: 22 nM

++

CDK4, IC50: 200 nM

{[allProObj[0].p_purity_real_show]}
RO-3306 +++

CDK1, Ki: 20 nM

ERK,SGK {[allProObj[0].p_purity_real_show]}
R547 ++++

CDK1/CyclinB, Ki: 2 nM

++++

CDK2/CyclinE, Ki: 3 nM

++++

CDK4/CyclinD1, Ki: 1 nM

{[allProObj[0].p_purity_real_show]}
BMS-265246 ++++

CDK1/CyclinB, IC50: 6 nM

++++

CDK2/CyclinE, IC50: 9 nM

+

CDK4/CyclinD, IC50: 230 nM

{[allProObj[0].p_purity_real_show]}
NU6027 +

CDK1, Ki: 2.5 μM

+

CDK2, Ki: 1.3 μM

DNA-PK {[allProObj[0].p_purity_real_show]}
Purvalanol A ++++

Cdc2/CyclinB, IC50: 4 nM

+++

CDK2/CyclinE, IC50: 35 nM

CDK2/CyclinA, IC50: 70 nM

+

CDK4/CyclinD1, IC50: 850 nM

{[allProObj[0].p_purity_real_show]}
SCH900776 ++

CDK2, IC50: 0.16 μM

{[allProObj[0].p_purity_real_show]}
AUZ 454 ++++

CDK2(A144C), Kd: 9.7 nM

CDK2(C118L), Kd: 18.6 nM

{[allProObj[0].p_purity_real_show]}
A-674563 HCl ++

CDK2, Ki: 46 nM

PKA {[allProObj[0].p_purity_real_show]}
JNJ-7706621 ++++

CDK1/CyclinB, IC50: 9 nM

++++

CDK2/CyclinE, IC50: 3 nM

CDK2/CyclinA, IC50: 4 nM

++

CDK3/CyclinE, IC50: 58 nM

+

CDK4/CyclinD1, IC50: 253 nM

++

CDK6/CyclinD1, IC50: 175 nM

{[allProObj[0].p_purity_real_show]}
AT7519 ++

CDK1/CyclinB, IC50: 210 nM

++

CDK2/CyclinA, IC50: 47 nM

+

CDK3/CyclinE, IC50: 360 nM

++

CDK4/CyclinD1, IC50: 100 nM

+++

CDK5/p35, IC50: 13 nM

++

CDK6/CyclinD3, IC50: 170 nM

++++

CDK9/CyclinT, IC50: <10 nM

{[allProObj[0].p_purity_real_show]}
PHA-793887 ++

CDK1/CyclinB, IC50: 60 nM

++++

CDK2/CyclinE, IC50: 8 nM

CDK2/CyclinA, IC50: 8 nM

++

CDK4/CyclinD1, IC50: 62 nM

++++

CDK5/p25, IC50: 5 nM

++++

CDK7/CyclinH, IC50: 10 nM

++

CDK9/CyclinT1, IC50: 138 nM

{[allProObj[0].p_purity_real_show]}
Milciclib +

CDK1/CyclinB, IC50: 398 nM

++

CDK2/CyclinE, IC50: 363 nM

CDK2/CyclinA, IC50: 45 nM

++

CDK4/CyclinD1, IC50: 160 nM

+

CDK5/p35, IC50: 265 nM

++

CDK7/CyclinH, IC50: 150 nM

{[allProObj[0].p_purity_real_show]}
Kenpaullone +

CDK1/CyclinB, IC50: 0.4μM

+

CDK2/CyclinE, IC50: 7.5μM

CDK2/CyclinA, IC50: 0.68μM

+

CDK5/p35, IC50: 0.85μM

{[allProObj[0].p_purity_real_show]}
SNS-032 +++

CDK2/CyclinE, IC50: 48 nM

CDK2/CyclinA, IC50: 38 nM

+

CDK5/p35, IC50: 340 nM

++

CDK7/CyclinH, IC50: 62 nM

++++

CDK9/CyclinT, IC50: 4 nM

{[allProObj[0].p_purity_real_show]}
Dinaciclib ++++

CDK1, IC50: 3 nM

++++

CDK2, IC50: 1 nM

++++

CDK5, IC50: 1 nM

++++

CDK9, IC50: 4 nM

{[allProObj[0].p_purity_real_show]}
PHA-767491 hydrochloride ++++

Cdc7, IC50: 10 nM

+

CDK1, IC50: 250 nM

+

CDK2, IC50: 240 nM

+

CDK5, IC50: 460 nM

+++

CDK9, IC50: 34 nM

MK2 {[allProObj[0].p_purity_real_show]}
(R)-Roscovitine +

Cdc2/CyclinB, IC50: 0.65 μM

+

CDK2/CyclinE, IC50: 0.7 μM

CDK2/CyclinA, IC50: 0.7 μM

++

CDK5/p35, IC50: 0.16 μM

{[allProObj[0].p_purity_real_show]}
Narazaciclib ++++

CDK4/CyclinD1, IC50: 3.87 nM

++++

CDK6/CyclinD1, IC50: 9.82 nM

RET {[allProObj[0].p_purity_real_show]}
Palbociclib ++++

CDK4/CyclinD1, IC50: 11 nM

CDK4/CyclinD3, IC50: 9 nM

+++

CDK6/CyclinD2, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
Abemaciclib ++++

CDK4, IC50: 2 nM

++++

CDK6, IC50: 10 nM

{[allProObj[0].p_purity_real_show]}
Ribociclib ++++

CDK4, IC50: 10 nM

+++

CDK6, IC50: 39 nM

{[allProObj[0].p_purity_real_show]}
Palbociclib isethionate ++++

CDK4/CyclinD1, IC50: 11 nM

CDK4/CyclinD3, IC50: 9 nM

+++

CDK6/CyclinD2, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
BS-181 HCl +++

CDK7, IC50: 21 nM

{[allProObj[0].p_purity_real_show]}
(E/Z)-THZ1 dihydrochloride ++++

CDK7, IC50: 3.2 nM

{[allProObj[0].p_purity_real_show]}
LDC4297 ++++

CDK7, IC50: 0.13 nM

{[allProObj[0].p_purity_real_show]}
Senexin A +

CDK19, Kd: 0.31 μM

+

CDK8, Kd: 0.83 μM

{[allProObj[0].p_purity_real_show]}
MSC2530818 ++++

CDK8, IC50: 2.6 nM

{[allProObj[0].p_purity_real_show]}
Wogonin {[allProObj[0].p_purity_real_show]}
Riviciclib HCl ++

CDK1/CyclinB, IC50: 79 nM

+

CDK2/CyclinE, IC50: 2.54 μM

CDK2/CyclinA, IC50: 224 nM

++

CDK4/CyclinD1, IC50: 63 nM

+

CDK6/CyclinD3, IC50: 396 nM

+

CDK7/CyclinH, IC50: 2.87 μM

+++

CDK9/CyclinT1, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
LDC000067 +

CDK2, IC50: 2.441 μM

++

CDK9, IC50: 44 nM

{[allProObj[0].p_purity_real_show]}
Flavopiridol +++

CDK1, IC50: 40 nM

+++

CDK2, IC50: 40 nM

+++

CDK4, IC50: 40 nM

+++

CDK6, IC50: 40 nM

+

CDK7, IC50: 300 nM

+++

CDK9, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
LY2857785 +

CDK7, IC50: 0.246 μM

+++

CDK8, IC50: 0.016 μM

+++

CDK9, IC50: 0.011 μM

{[allProObj[0].p_purity_real_show]}
AZD-5438 +++

CDK1, IC50: 16 nM

++++

CDK2, IC50: 6 nM

+++

CDK9, IC50: 20 nM

{[allProObj[0].p_purity_real_show]}
ML167 ++

Dyrk1B , IC50: 1648 nM

CLK4, IC50: 136 nM

{[allProObj[0].p_purity_real_show]}
(E/Z)-TG003 +++

mCLK1, IC50: 200 nM

mCLK4, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 C2β p110α p110β p110γ p110δ PI3K Vps34 其他靶点 纯度
A66 +

C2β, IC50: 462 nM

++

p110α, IC50: 32 nM

{[allProObj[0].p_purity_real_show]}
Taselisib +

C2β, IC50: 292 nM

++++

PI3Kα, Ki: 0.29 nM

+++

PI3Kβ, Ki: 9.1 nM

++++

PI3Kγ, Ki: 0.97 nM

++++

PI3Kδ, Ki: 0.12 nM

+

hVps34, IC50: 374 nM

{[allProObj[0].p_purity_real_show]}
Gedatolisib ++++

PI3Kα, IC50: 0.4 nM

+++

PI3Kγ, IC50: 5.4 nM

mTOR {[allProObj[0].p_purity_real_show]}
HS-173 ++++

PI3Kα , IC50: 0.8 nM

{[allProObj[0].p_purity_real_show]}
Serabelisib +++

PI3Kα, IC50: 21 nM

{[allProObj[0].p_purity_real_show]}
GNE-477 ++++

PI3Kα, IC50: 4 nM

mTOR {[allProObj[0].p_purity_real_show]}
YM-201636 +

p110α, IC50: 3.3 μM

PIKfyve {[allProObj[0].p_purity_real_show]}
AS-252424 +

PI3Kα, IC50: 935 nM

++

PI3Kγ, IC50: 33 nM

{[allProObj[0].p_purity_real_show]}
Alpelisib +++

PI3Kα, IC50: 5 nM

{[allProObj[0].p_purity_real_show]}
AS-604850 +

PI3Kα, IC50: 4.5 μM

+

PI3Kγ, IC50: 0.25 μM

{[allProObj[0].p_purity_real_show]}
SF2523 ++

PI3Kα, IC50: 34 nM

++

PI3Kγ, IC50: 158 nM

mTOR,DNA-PK {[allProObj[0].p_purity_real_show]}
Inavolisib ++++

PI3K alpha, IC50: 0.038 nM

{[allProObj[0].p_purity_real_show]}
Bimiralisib ++++

PI3Kα, Kd: 1.5 nM

+++

PI3Kβ, Kd: 11 nM

++

PI3Kγ, Kd: 25 nM

++

PI3Kδ, Kd: 25 nM

mTOR {[allProObj[0].p_purity_real_show]}
GSK1059615 ++++

PI3Kα, IC50: 0.4 nM

++++

PI3Kβ, IC50: 0.6 nM

+++

PI3Kγ, IC50: 5 nM

++++

PI3Kδ, IC50: 2 nM

mTOR {[allProObj[0].p_purity_real_show]}
GSK2636771 {[allProObj[0].p_purity_real_show]}
Fimepinostat +++

PI3Kα, IC50: 19 nM

++

PI3Kβ, IC50: 54 nM

++

PI3Kδ, IC50: 39 nM

{[allProObj[0].p_purity_real_show]}
VS-5584 ++++

PI3Kα, IC50: 2.6 nM

+++

PI3Kβ, IC50: 21 nM

++++

PI3Kγ, IC50: 3.0 nM

++++

PI3Kδ, IC50: 2.7 nM

mTOR {[allProObj[0].p_purity_real_show]}
Dactolisib ++++

p110α1, IC50: 4 nM

++

p110β, IC50: 75 nM

+++

p110γ, IC50: 5 nM

+++

p110δ, IC50: 7 nM

{[allProObj[0].p_purity_real_show]}
PI-103 ++++

p110α, IC50: 2 nM

++++

p110β, IC50: 3 nM

+++

p110γ, IC50: 15 nM

++++

p110δ, IC50: 3 nM

mTOR,DNA-PK {[allProObj[0].p_purity_real_show]}
PI-3065 +

p110β, IC50: 1078 nM

+++

p110δ, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
Voxtalisib ++

PI3Kα, IC50: 39 nM

++

PI3Kβ, IC50: 113 nM

+++

PI3Kγ, IC50: 9 nM

++

PI3Kδ, IC50: 43 nM

mTOR,DNA-PK {[allProObj[0].p_purity_real_show]}
AZD-8835 +++

PI3Kα, IC50: 6.2 nM

+

PI3Kβ, IC50: 431 nM

++

PI3Kγ, IC50: 90 nM

+++

PI3Kδ, IC50: 5.7 nM

{[allProObj[0].p_purity_real_show]}
Pilaralisib analogue ++

PI3Kα, IC50: 39 nM

++

PI3Kβ, IC50: 36 nM

+++

PI3Kγ, IC50: 23 nM

++

PI3Kδ, IC50: 36 nM

{[allProObj[0].p_purity_real_show]}
ZSTK474 +++

PI3Kα, IC50: 16 nM

++

PI3Kβ, IC50: 44 nM

++

PI3Kγ, IC50: 49 nM

+++

PI3Kδ, IC50: 4.6 nM

++

PI3K, IC50: 37 nM

{[allProObj[0].p_purity_real_show]}
AS-605240 ++

PI3Kα, IC50: 60 nM

+

PI3Kβ, IC50: 270 nM

+++

PI3Kγ, IC50: 8 nM

+

PI3Kδ, IC50: 300 nM

{[allProObj[0].p_purity_real_show]}
TGX-221 +++

p110β, IC50: 5 nM

++

p110δ, IC50: 0.1 μM

{[allProObj[0].p_purity_real_show]}
PF-04691502 ++++

PI3Kα, Ki: 1.8 nM

++++

PI3Kβ, Ki: 2.1 nM

++++

PI3Kγ, Ki: 1.9 nM

++++

PI3Kδ, Ki: 1.6 nM

mTOR {[allProObj[0].p_purity_real_show]}
GDC-0084 ++++

PI3Kα, Ki app: 2 nM

++

PI3Kβ, Ki app: 46 nM

+++

PI3Kγ, Ki app: 10 nM

++++

PI3Kδ, Ki app: 3 nM

mTOR {[allProObj[0].p_purity_real_show]}
Buparlisib ++

p110α, IC50: 52 nM

+

p110β, IC50: 166 nM

+

p110γ, IC50: 262 nM

++

p110δ, IC50: 116 nM

+

Vps34, IC50: 2.4 μM

mTOR {[allProObj[0].p_purity_real_show]}
LY294002 +

p110α, IC50: 0.5 μM

+

p110β, IC50: 0.97 μM

+

p110δ, IC50: 0.57 μM

DNA-PK {[allProObj[0].p_purity_real_show]}
AZD 6482 +

PI3Kα, IC50: 870 nM

+++

PI3Kβ, IC50: 10 nM

++

PI3Kδ, IC50: 80 nM

DNA-PK {[allProObj[0].p_purity_real_show]}
Pictilisib ++++

p110α, IC50: 3 nM

++

p110β, IC50: 33 nM

++

p110γ, IC50: 75 nM

++++

p110δ, IC50: 3 nM

mTOR {[allProObj[0].p_purity_real_show]}
PKI-402 ++++

PI3Kα, IC50: 2 nM

+++

PI3Kβ, IC50: 7 nM

+++

PI3Kγ, IC50: 16 nM

+++

PI3Kδ, IC50: 14 nM

mTOR {[allProObj[0].p_purity_real_show]}
Copanlisib ++++

PI3Kα, IC50: 0.5 nM

++++

PI3Kβ, IC50: 3.7 nM

+++

PI3Kγ, IC50: 6.4 nM

++++

PI3Kδ, IC50: 0.7 nM

{[allProObj[0].p_purity_real_show]}
Omipalisib ++++

p110α, Ki: 0.019 nM

++++

p110β, Ki: 0.13 nM

++++

p110γ, Ki: 0.06 nM

++++

p110δ, Ki: 0.024 nM

{[allProObj[0].p_purity_real_show]}
Izorlisib +++

PI3Kα, IC50: 14 nM

++

PI3Kβ, IC50: 0.12 μM

++

PI3Kγ, IC50: 36 nM

+

PI3Kδ, IC50: 0.50 μM

{[allProObj[0].p_purity_real_show]}
AZD8186 ++

PI3Kα, IC50: 35 nM

++++

PI3Kβ, IC50: 4 nM

+++

PI3Kδ, IC50: 12 nM

{[allProObj[0].p_purity_real_show]}
KU-0060648 ++++

PI3Kα, IC50: 4 nM

++++

PI3Kβ, IC50: 0.5 nM

+

PI3Kγ, IC50: 0.59 μM

++++

PI3Kδ, IC50: 0.1 nM

DNA-PK {[allProObj[0].p_purity_real_show]}
Apitolisib +++

p110α, IC50: 5 nM

++

p110β, IC50: 27 nM

+++

p110γ, IC50: 14 nM

+++

p110δ, IC50: 7 nM

mTOR {[allProObj[0].p_purity_real_show]}
CZC24832 +

PI3Kβ, IC50: 1.1 μM

++

PI3Kγ, IC50: 27 nM

{[allProObj[0].p_purity_real_show]}
BGT226 maleate ++++

PI3Kα, IC50: 4 nM

++

PI3Kβ, IC50: 63 nM

++

PI3Kγ, IC50: 38 nM

mTOR {[allProObj[0].p_purity_real_show]}
TG 100713 ++

PI3Kα, IC50: 165 nM

+

PI3Kβ, IC50: 215 nM

++

PI3Kγ, IC50: 50 nM

+++

PI3Kδ, IC50: 24 nM

{[allProObj[0].p_purity_real_show]}
PI3K-IN-1 ++

PI3Kα, IC50: 39 nM

++

PI3Kβ, IC50: 113 nM

+++

PI3Kγ, IC50: 9 nM

++

PI3Kδ, IC50: 43 nM

mTOR,DNA-PK {[allProObj[0].p_purity_real_show]}
TG100-115 +

PI3Kα, IC50: 1.3 μM

+

PI3Kβ, IC50: 1.2 μM

++

PI3Kγ, IC50: 83 nM

+

PI3Kδ, IC50: 235 nM

{[allProObj[0].p_purity_real_show]}
PIK-90 +++

PI3Kα, IC50: 11 nM

+

PI3Kβ, IC50: 350 nM

+++

PI3Kγ, IC50: 18 nM

++

PI3Kδ, IC50: 58 nM

{[allProObj[0].p_purity_real_show]}
PIK-294 +

p110β, IC50: 490 nM

++

p110γ, IC50: 160 nM

+++

p110δ, IC50: 10 nM

{[allProObj[0].p_purity_real_show]}
Duvelisib ++++

PI3Kβ, Ki: 1564 pM

++

PI3Kγ, Ki: 243 pM

++++

PI3Kδ, Ki: 23 pM

{[allProObj[0].p_purity_real_show]}
GDC-0326 ++++

PI3Kα, Ki: 0.2 nM

++

PI3Kβ, Ki: 26.6 nM

+++

PI3Kγ, Ki: 10.2 nM

++++

PI3Kδ, Ki: 4 nM

{[allProObj[0].p_purity_real_show]}
Quercetin Dihydrate +

PI3Kβ, IC50: 5.4 μM

+

PI3Kγ, IC50: 2.4 μM

+

PI3Kδ, IC50: 3.0 μM

{[allProObj[0].p_purity_real_show]}
Quercetin +

PI3Kβ, IC50: 5.4 μM

+

PI3Kγ, IC50: 2.4 μM

+

PI3Kδ, IC50: 3.0 μM

Src,Sirtuin,PKC {[allProObj[0].p_purity_real_show]}
Leniolisib +

PI3Kα, IC50: 0.244 μM

+

PI3Kβ, IC50: 0.424 μM

+

PI3Kγ, IC50: 2.23 μM

+++

PI3Kδ, IC50: 0.011 μM

DNA-PK {[allProObj[0].p_purity_real_show]}
PIK-108 {[allProObj[0].p_purity_real_show]}
Eganelisib +++

PI3Kγ, IC50: 16 nM

{[allProObj[0].p_purity_real_show]}
CAY10505 {[allProObj[0].p_purity_real_show]}
IPI-3063 ++++

p110δ, IC50: 2.5 nM

{[allProObj[0].p_purity_real_show]}
Nemiralisib ++++

PI3Kδ, pKi: 9.9

{[allProObj[0].p_purity_real_show]}
PF-4989216 ++++

p110α, IC50: 2 nM

++

p110γ, IC50: 65 nM

++++

p110δ, IC50: 1 nM

{[allProObj[0].p_purity_real_show]}
PIK-75 HCl +++

p110α, IC50: 5.8 nM

++

p110γ, IC50: 76 nM

+

p110δ, IC50: 0.51 μM

DNA-PK {[allProObj[0].p_purity_real_show]}
Tenalisib ++

PI3Kγ, IC50: 33.2 nM

++

PI3Kδ, IC50: 24.5 nM

{[allProObj[0].p_purity_real_show]}
Acalisib +++

p110δ, IC50: 14 nM

{[allProObj[0].p_purity_real_show]}
Umbralisib +++

PI3Kδ, IC50: 22.2 nM

{[allProObj[0].p_purity_real_show]}
AMG319 +

PI3Kγ, IC50: 850 nM

+++

PI3Kδ, IC50: 18 nM

{[allProObj[0].p_purity_real_show]}
IC-87114 +

PI3Kγ, IC50: 29 μM

+

PI3Kδ, IC50: 0.5 μM

{[allProObj[0].p_purity_real_show]}
Idelalisib ++

p110γ, IC50: 89 nM

++++

p110δ, IC50: 2.5 nM

{[allProObj[0].p_purity_real_show]}
PIK-293 +

p110γ, IC50: 10 μM

+

p110δ, IC50: 0.24 μM

{[allProObj[0].p_purity_real_show]}
Vps34-PIK-III +

PI3Kδ, IC50: 1.2μM

+++

Vps34, IC50: 0.018μM

{[allProObj[0].p_purity_real_show]}
GSK2292767 {[allProObj[0].p_purity_real_show]}
Seletalisib +

PI3Kγ, IC50: 282 nM

+++

PI3Kδ, IC50: 12 nM

{[allProObj[0].p_purity_real_show]}
P110δ-IN-1 ++++

P110δ, IC50: 0.6 nM

{[allProObj[0].p_purity_real_show]}
PI3Kδ-IN-5 ++++

PI3Kδ, IC50: 0.9 nM

{[allProObj[0].p_purity_real_show]}
SRX3207 +

PI3K alpha, IC50: 244 nM

+

PI3K gamma, IC50: 9790 nM

+

PI3K delta, IC50: 388 nM

Syk {[allProObj[0].p_purity_real_show]}
Parsaclisib HCl ++++

PI3Kδ, IC50: 1 nM

{[allProObj[0].p_purity_real_show]}
IHMT-PI3Kδ-372 +++

PI3Kδ, IC50: 14 nM

{[allProObj[0].p_purity_real_show]}
Trigonelline Akt {[allProObj[0].p_purity_real_show]}
Wortmannin ++++

PI3K, IC50: 3 nM

MLCK,DNA-PK {[allProObj[0].p_purity_real_show]}
Samotolisib DNA-PK {[allProObj[0].p_purity_real_show]}
GNE-317 {[allProObj[0].p_purity_real_show]}
Oroxin B Akt,PTEN {[allProObj[0].p_purity_real_show]}
NU 7026 +

PI3K, IC50: 13 μM

DNA-PK {[allProObj[0].p_purity_real_show]}
Deguelin Akt {[allProObj[0].p_purity_real_show]}
Ailanthone Akt,CDK,ATM/ATR {[allProObj[0].p_purity_real_show]}
Resibufogenin ROS {[allProObj[0].p_purity_real_show]}
KU-57788 +

PI3K, IC50: 5 μM

mTOR,DNA-PK {[allProObj[0].p_purity_real_show]}
Cinobufagine Akt {[allProObj[0].p_purity_real_show]}
α-Linolenic acid {[allProObj[0].p_purity_real_show]}
MTX-211 EGFR {[allProObj[0].p_purity_real_show]}
PI3K/mTOR Inhibitor-2 ++++

PI3K, IC50: 3.4 nM

mTOR {[allProObj[0].p_purity_real_show]}
SPP-86 {[allProObj[0].p_purity_real_show]}
(E)-Akt inhibitor-IV {[allProObj[0].p_purity_real_show]}
Vps34-IN-1 ++

Vps34, IC50: 25 nM

{[allProObj[0].p_purity_real_show]}
SAR405 ++++

Vps34, IC50: 1.2 nM

{[allProObj[0].p_purity_real_show]}
3-Methyladenine +

PI3Kγ, IC50: 60 μM

+

Vps34, IC50: 25 μM

Autophagy {[allProObj[0].p_purity_real_show]}
Vps34-IN-4 +++

VPS34, IC50: 15 nM

{[allProObj[0].p_purity_real_show]}
Autophinib +++

Vps34, IC50: 19 nM

Autophagy {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

SRX3177 生物活性

描述 SRX3177 serves as a multifaceted inhibitor targeting CDK4/6, PI3K, and BRD4, demonstrating IC50s of 33 nM for BRD4 BD1, 89 nM for BRD4 BD2, 79 nM for PI3Kα, 83 nM for PI3Kδ, 3.18 μM for PI3Kγ, less than 2.5 nM for CDK4, and 3.3 nM for CDK6. It exhibits extensive cytotoxic effects on cancerous cells while sparing normal epithelial cells[1].

SRX3177 参考文献

[1]Burgoyne AM, et al. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49.

SRX3177 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.71mL

0.34mL

0.17mL

8.55mL

1.71mL

0.86mL

17.10mL

3.42mL

1.71mL

SRX3177 技术信息

CAS号2241237-51-2
分子式C31H32N6O4S
分子量 584.689
别名
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 25 mg/mL(42.76 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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