货号:A498292
同义名:
胡芦巴碱
/ Trigenolline
Trigonelline, a natural product isolated and purified from the seeds of Trigonella foenum-graecum L. with phytoestrogenic and antitumor effects, inhibits the adipogenesis by its influences on the expression PPARγ, which leads to subsequent down regulation of PPAR-γ mediated pathway during adipogenesis.
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产品名称 | Ferroptosis ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ferrostatin-1 |
++
Ferroptosis, EC50: 60 nM |
98% | |||||||||||||||||
Liproxstatin-1 |
+++
ferroptosis, IC50: 22 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | Autophagy ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SBI-0206965 |
+++
ULK1, IC50: 108 nM ULK2, IC50: 711 nM |
97% | |||||||||||||||||
Hydroxychloroquine sulfate | ✔ | 99% | |||||||||||||||||
Valproic acid sodium | ✔ | HDAC | 97% | ||||||||||||||||
PFK-015 |
++
PFKFB3, IC50: 207 nM |
99%+ | |||||||||||||||||
MRT68921 hydrochloride |
++++
ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM |
99%+ | |||||||||||||||||
ROC-325 | ✔ | 99%+ | |||||||||||||||||
Autophinib |
+++
Autophagy, IC50: 40 nM |
99%+ | |||||||||||||||||
Lys05 | ✔ | 99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Trigonelline, a natural product isolated and purified from the seeds of Trigonella foenum-graecum L. with phytoestrogenic and antitumor effects, inhibits the adipogenesis by its influences on the expression PPARγ, which leads to subsequent down regulation of PPAR-γ mediated pathway during adipogenesis. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02999152 | Bone Metastasis ... 展开 >> Malignant Hemopathy 收起 << | Not Applicable | Recruiting | December 31, 2019 | France ... 展开 >> Institut de Cancérologie Lucien Neuwirth Recruiting Saint-Priest en Jarez, France, 42270 Principal Investigator: Nicolas Magné, PhD Sub-Investigator: Guy De Laroche, MD Sub-Investigator: Grégoire Pigne, MD Sub-Investigator: Denis Guyotat, PhD Sub-Investigator: Jérôme Cornillon, MD Institut Gustave Roussy Not yet recruiting Villejuif, France, 94800 Contact: Valentine Martin, MD Principal Investigator: Valentine Martin, MD Sub-Investigator: Angela Boros, MD 收起 << |
NCT03166540 | Diet Modification ... 展开 >> Cardiovascular Risk Factor Nutritional and Metabolic Diseases 收起 << | Not Applicable | Completed | - | Italy ... 展开 >> Department of Food and Drug, University of Parma Parma, Italy, 43125 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
7.29mL 1.46mL 0.73mL |
36.46mL 7.29mL 3.65mL |
72.92mL 14.58mL 7.29mL |
CAS号 | 535-83-1 |
分子式 | C7H7NO2 |
分子量 | 137.136 |
别名 | 胡芦巴碱 ;Trigenolline |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 6 mg/mL(43.75 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |