There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Quercetin, recognized for its presence in various dietary sources as a natural flavonoid, serves dual roles both as a stimulator of recombinant SIRT1 and as an inhibitor of PI3K, exhibiting IC50 values between 2.4 and 5.4 μM across different PI3K isoforms[1]. Quercetin GMP, which is Quercetin produced under Good Manufacturing Practice (GMP) guidelines, serves as an auxiliary reagent in cell therapy manufacturing, leveraging its status as a flavonoid antioxidant, PI3K inhibitor, and SIRT1 activator[1].[2].[3].[4].[5].[6].
体内研究
In vivo, a combination of quercetin (75 mg/kg) with 2-Methoxyestradiol notably suppresses tumor growth in human prostate cancer LNCaP and PC-3 cells xenograft models[3].
体外研究
Beyond its enzymatic inhibition profile, quercetin has been attributed anti-inflammatory and antioxidant properties, potentially offering a broad spectrum of health benefits. Its inhibitory activity spans multiple kinases, notably downregulating PI3K and Src kinases, while exerting a milder inhibitory effect on Akt1/2, and minimal impact on PKC, p38, and ERK1/2 pathways[1].
Further, quercetin effectively counters TNF-induced lactate dehydrogenase (LDH) release, endothelial cell (EC)-dependent neutrophil adhesion to bovine pulmonary artery endothelial cells (BPAEC), and the synthesis and proliferation of BPAEC DNA[2].
Quercetin GMP promotes osteogenesis in mesenchymal stem cells at concentrations of 10, 50, and 100 μM[1].
Quercetin GMP also dose-dependently reduces osteoclastogenesis induced by RANKL at concentrations ranging from 0.1 to 10 μM[2].
Moreover, Quercetin GMP enhances osteogenic differentiation and the secretion of angiogenic factors in rat bone marrow-derived mesenchymal stem cells (rBMSCs) at a dose of 2 μM[3].
At concentrations between 2 to 5 μM, it inhibits bone resorption by obstructing the differentiation and activation of osteoclasts[4].
At concentrations of 5 μM, Quercetin dose-dependently increases osteogenic differentiation[5].
Quercetin 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
HEK293 FS cells
Function assay
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM
20731357
HT22 cells
Function assay
Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM
16392814
HT22 cells
Function assay
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM
24602904
human 2008 cells
Cytotoxicity assay
72 h
Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=21.18 μM
Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM
20731357
HT22 cells
Function assay
Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM
16392814
HT22 cells
Function assay
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM
24602904
human 2008 cells
Cytotoxicity assay
72 h
Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=21.18 μM
25906385
human A431 cells
Cytotoxicity assay
72 h
Cytotoxicity against human A431 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=23.04 μM
25906385
human A549 cells
Function assay
Anticancer activity against human A549 cells by HTS assay, IC50=6.2 μM
25139569
human BV2 cells
Function assay
24 h
Inhibition of LPS-stimulated NO production in human BV2 cells after 24 hrs by Griess assay, IC50=4.3 μM
25127164
human BV2 cells
Function assay
Antiinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced nitric oxide production by Griess assay, IC50=10 μM
24707938
human BxPC3 cells
Cytotoxicity assay
72 h
Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=24.12 μM
25906385
human H460 cells
Function assay
Anticancer activity against human H460 cells by HTS assay, IC50=9.62 μM
25139569
human HCT116 cells
Growth inhibition assay
48 h
Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay, IC50=5.7 μM
22212721
human HCT116 cells
Growth inhibition assay
48 h
Growth inhibition of human HCT116 cells after 48 hrs by MTT assay, IC50=6.7 μM
22212721
human HeLa cells
Function assay
Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM
19725578
human HepG2 cells
Cytotoxicity assay
Cytotoxicity against human HepG2 cells by MTT assay, IC50=30.9 μM
21726077
human HOP62 cells
Function assay
Anticancer activity against human HOP62 cells by HTS assay, IC50=7.52 μM
25139569
human HTLA cells
Function assay
20 mins
Inhibition of CX3CL1-stimulated CX3CR1 in human HTLA cells pre-incubated for 20 mins measured on day 4 by beta arrestin-recruitment mediated luciferase reporter gene assay, IC50=4.5 μM
23437772
human LOXIMVI cells
Function assay
Anticancer activity against human LOXIMVI cells by HTS assay, IC50=4.65 μM
25139569
human MCF7 cells
Cytotoxicity assay
72 h
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=20.9 μM
25906385
human MDA-MB-231 cells
20 μM
Function assay
12 h
Induction of apoptosis in human MDA-MB-231 cells assessed as cleaved caspase-7 accumulation at 20 uM after 12 hrs by Western blot analysis
21652208
human NCI-H157 cells
Function assay
Anticancer activity against human NCI-H157 cells by HTS assay, IC50=6 μM
25139569
human NCI-H522 cells
Function assay
Anticancer activity against human NCI-H522 cells by HTS assay, IC50=5.77 μM
25139569
human U2OS cells
Function assay
Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay, EC50=5.93 μM
24900447
Jurkat T cells
Function assay
Activity against hydrogen peroxide induced DNA damage in Jurkat T cells, IC50=5 μM
16392814
MDCK cells
Function assay
Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=6.9 μM
21354800
NCI-H1792 cells
Function assay
Anticancer activity against human NCI-H1792 cells by HTS assay, IC50=3.85 μM
25139569
RAW264.7 cells
Function assay
24 h
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs, IC50=1.3 μM
23540981
RBL-1 cells
Function assay
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=0.2 μM
8254620
Sf9 cells
Function assay
Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method, Ki=45.3 nM
搜索
HazMat Fee +
