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首页 / 药物研究 / 药物分析 / 植提标准品 / Quercetin

槲皮素 /Quercetin {[allProObj[0].p_purity_real_show]}

货号：A292006 同义名： Sophoretin;C.I. 75720

Quercetin是一种类黄酮抗氧化剂、PI3K抑制剂和SIRT1激活剂。

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Type HazMat fee for 500 gram (Estimated)
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Quercetin 化学结构 CAS号：117-39-5
Quercetin 化学结构
CAS号：117-39-5
Quercetin 3D分子结构
CAS号：117-39-5
Quercetin 化学结构 CAS号：117-39-5
Quercetin 3D分子结构 CAS号：117-39-5
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Quercetin 纯度/质量文件 产品仅供科研

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Quercetin 生物活性

靶点

  • p110γ

    PI3Kγ, IC50:2.4 μM

  • p110β

    PI3Kβ, IC50:5.4 μM

  • p110δ

    PI3Kδ, IC50:3.0 μM

  • PKC

  • Src
描述 Quercetin, recognized for its presence in various dietary sources as a natural flavonoid, serves dual roles both as a stimulator of recombinant SIRT1 and as an inhibitor of PI3K, exhibiting IC50 values between 2.4 and 5.4 μM across different PI3K isoforms[1]. Quercetin GMP, which is Quercetin produced under Good Manufacturing Practice (GMP) guidelines, serves as an auxiliary reagent in cell therapy manufacturing, leveraging its status as a flavonoid antioxidant, PI3K inhibitor, and SIRT1 activator[1].[2].[3].[4].[5].[6].
体内研究

In vivo, a combination of quercetin (75 mg/kg) with 2-Methoxyestradiol notably suppresses tumor growth in human prostate cancer LNCaP and PC-3 cells xenograft models[3].
体外研究

Beyond its enzymatic inhibition profile, quercetin has been attributed anti-inflammatory and antioxidant properties, potentially offering a broad spectrum of health benefits. Its inhibitory activity spans multiple kinases, notably downregulating PI3K and Src kinases, while exerting a milder inhibitory effect on Akt1/2, and minimal impact on PKC, p38, and ERK1/2 pathways[1].

Further, quercetin effectively counters TNF-induced lactate dehydrogenase (LDH) release, endothelial cell (EC)-dependent neutrophil adhesion to bovine pulmonary artery endothelial cells (BPAEC), and the synthesis and proliferation of BPAEC DNA[2].

Quercetin GMP promotes osteogenesis in mesenchymal stem cells at concentrations of 10, 50, and 100 μM[1].

Quercetin GMP also dose-dependently reduces osteoclastogenesis induced by RANKL at concentrations ranging from 0.1 to 10 μM[2].

Moreover, Quercetin GMP enhances osteogenic differentiation and the secretion of angiogenic factors in rat bone marrow-derived mesenchymal stem cells (rBMSCs) at a dose of 2 μM[3].

At concentrations between 2 to 5 μM, it inhibits bone resorption by obstructing the differentiation and activation of osteoclasts[4].

At concentrations of 5 μM, Quercetin dose-dependently increases osteogenic differentiation[5].

Quercetin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
HEK293 FS cells Function assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM 20731357
HT22 cells Function assay Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM 16392814
HT22 cells Function assay Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM 24602904
human 2008 cells Cytotoxicity assay 72 h Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=21.18 μM 25906385

Quercetin 参考文献

[1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.

[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.

[3]Zhou Y, et al. The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One. 2015 Jun 8;10(6):e0129605.

[4]Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9.

[5]Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78.

[6]Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021.

Quercetin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL

Quercetin 技术信息

CAS号117-39-5
分子式C15H10O7
分子量 302.236
别名 Sophoretin;C.I. 75720;Xanthaurine.;Quertine;Quercetol;Quercetine;NSC 9219;NCI-C60106;Meletin;Kvercetin;NSC 9221
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(347.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 15 mg/mL(49.63 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

2% DMSO+30% PEG 300+2% Tween 80+water 6 mg/mL

Tags: Quercetin | Sophoretin;C.I. 75720;Xanthaurine.;Quertine;Quercetol;Quercetine;NSC 9219;NCI-C60106;Meletin;Kvercetin;NSC 9221 | Plant Standard | AmBeed-信号通路专用抑制剂 | Quercetin 纯度/质量文件 | Quercetin 生物活性 | Quercetin 细胞研究 | Quercetin 参考文献 | Quercetin 实验方案 | Quercetin 技术信息

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