There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
靶点 |
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描述 | Quercetin, recognized for its presence in various dietary sources as a natural flavonoid, serves dual roles both as a stimulator of recombinant SIRT1 and as an inhibitor of PI3K, exhibiting IC50 values between 2.4 and 5.4 μM across different PI3K isoforms[1]. Quercetin GMP, which is Quercetin produced under Good Manufacturing Practice (GMP) guidelines, serves as an auxiliary reagent in cell therapy manufacturing, leveraging its status as a flavonoid antioxidant, PI3K inhibitor, and SIRT1 activator[1].[2].[3].[4].[5].[6]. |
体内研究 | In vivo, a combination of quercetin (75 mg/kg) with 2-Methoxyestradiol notably suppresses tumor growth in human prostate cancer LNCaP and PC-3 cells xenograft models[3]. |
体外研究 | Beyond its enzymatic inhibition profile, quercetin has been attributed anti-inflammatory and antioxidant properties, potentially offering a broad spectrum of health benefits. Its inhibitory activity spans multiple kinases, notably downregulating PI3K and Src kinases, while exerting a milder inhibitory effect on Akt1/2, and minimal impact on PKC, p38, and ERK1/2 pathways[1]. Further, quercetin effectively counters TNF-induced lactate dehydrogenase (LDH) release, endothelial cell (EC)-dependent neutrophil adhesion to bovine pulmonary artery endothelial cells (BPAEC), and the synthesis and proliferation of BPAEC DNA[2]. Quercetin GMP promotes osteogenesis in mesenchymal stem cells at concentrations of 10, 50, and 100 μM[1]. Quercetin GMP also dose-dependently reduces osteoclastogenesis induced by RANKL at concentrations ranging from 0.1 to 10 μM[2]. Moreover, Quercetin GMP enhances osteogenic differentiation and the secretion of angiogenic factors in rat bone marrow-derived mesenchymal stem cells (rBMSCs) at a dose of 2 μM[3]. At concentrations between 2 to 5 μM, it inhibits bone resorption by obstructing the differentiation and activation of osteoclasts[4]. At concentrations of 5 μM, Quercetin dose-dependently increases osteogenic differentiation[5]. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
HEK293 FS cells | Function assay | Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM | 20731357 | ||
HT22 cells | Function assay | Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM | 16392814 | ||
HT22 cells | Function assay | Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM | 24602904 | ||
human 2008 cells | Cytotoxicity assay | 72 h | Cytotoxicity against human 2008 cells assessed as cell growth inhibition after 72 hrs by MTT assay, IC50=21.18 μM | 25906385 | |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.31mL 0.66mL 0.33mL |
16.54mL 3.31mL 1.65mL |
33.09mL 6.62mL 3.31mL |
CAS号 | 117-39-5 |
分子式 | C15H10O7 |
分子量 | 302.236 |
别名 | Sophoretin;C.I. 75720;Xanthaurine.;Quertine;Quercetol;Quercetine;NSC 9219;NCI-C60106;Meletin;Kvercetin;NSC 9221 |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(347.41 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 无水乙醇: 15 mg/mL(49.63 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇 |
动物实验配方 |
2% DMSO+30% PEG 300+2% Tween 80+water 6 mg/mL |