BI 2536 | PLK1 Inhibitor | AmBeed-信号通路专用抑制剂

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BI 2536 99%+

货号：A203461

BI 2536是一种PLK1和BRD4的双重抑制剂，对它们的IC50分别为0.83 nM和25 nM。BI-2536还抑制IFNB基因转录。

BI 2536 化学结构
CAS号：755038-02-9

BI 2536 3D分子结构
CAS号：755038-02-9

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BI 2536 纯度/质量文件产品仅供科研

货号：A203461 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

表观遗传阅读框亚型比较
PLK 亚型比较

产品名称	BET ↓ ↑	bromodomain ↓ ↑	BRPF ↓ ↑	CBP/beta-catenin ↓ ↑	p300/CBP ↓ ↑	其他靶点	纯度
MS436	++ BRD4 (2), Ki: 0.34 μM BRD4 (1), Ki: <0.085 μM						99%+
CPI-203	+++ BRD4, IC50: 37 nM						99+%
GSK1324726A	+++ BRD2, IC50: 31 nM BRD4, IC50: 22 nM						99%+
PFI-1	++ BRD2, IC50: 98 nM BRD4, IC50: 0.22 μM						98%
Apabetalone	+ BD2, IC50: 0.51 μM						99%
(+)-JQ1	+++ BRD4 (1), IC50: 77 nM BRD4 (2), IC50: 33 nM						98%
I-BET151	+ BRD3, IC50: 0.25 μM BRD4, IC50: 0.5 μM						98%
Molibresib	+++ BET proteins, IC50: 35 nM						99%+
I-BRD9	+++ BRD9, pIC50: 7.3 BRD4, pIC50: 5.3						99%+
BI-7273	++++ BRD7, IC50: 117 nM BRD9, IC50: 19 nM						99+%
Pelabresib	+++ BRD4-BD1, IC50: 39 nM						98%
ARV-825	+++ BRD4 BD1, Kd: 90 nM BRD4 BD2, Kd: 28 nM						99%+
Birabresib							99%+
BI 2536	+++ BRD4, Kd: 37 nM					c-Myc	99%+
Bromosporine	++ BRD2, IC50: 0.29 μM BRD9, IC50: 0.122 μM	++++ CECR2, IC50: 17 nM					99%+
XMD8-92	++ BRD4 (1), Kd: 170 nM						99%+
Mivebresib	✔						99%+
BI-9564	++++ BRD9, Kd: 5.9 nM BRD7, Kd: 73 nM	++ CECR2, Kd: 77 nM					98%
AZD5153 6-Hydroxy-2-naphthoic acid	++++ FL-BRD4, IC50: 5 nM						99%+
PLX51107	++++ BRD3 BD1, Kd: 2.1 nM BRD4 BD2, Kd: 1.7 nM						99%+
FL-411	+ BRD4(1), IC50: 0.43 μM						99%+
ABBV-744	✔						99%+
dBET6	++++ BRD4, IC50: 14 nM						99%+
dBET1	++++ BRD4, IC50: 20 nM						99%+
MZ1	++++ Brd2(BD2), Kd: 62 nM Brd3(BD2), Kd: 13 nM						99%+
dBET57	+ BRD4_BD1, DC50: 500 nM						99%+
SF2523	+ BRD4, IC50: 241 nM					DNA-PK	99%+
INCB054329	++++ BRD4-BD1, IC50: 119 nM BRD3-BD1, IC50: 9 nM						99%
INCB-057643	✔						99%+
(E/Z)-ZL0420	+++ BRD4 BD1, IC50: 27 nM BRD4 BD2, IC50: 32 nM						99%+
BMS-986158	✔						99%+
BRD4 Inhibitor-10	++++ BRD4-BD1, IC50: 5 nM BRD4-BD2, IC50: 41 nM						97%
A1874	✔						99%+
Y06036	++ BRD4 (1), Kd: 82 nM						99%+
Alobresib	✔					NF-κB	98%
ODM-207	✔						99%
GSK778	+++ BRD2-BD1, IC50: 75nM BRD4-BD1, IC50: 143 nM						97%
SRX3207	+ BRD41, IC50: 3070 nM BRD42, IC50: 3070 nM					Syk	98%
GSK046	+++ BRD4_BD2, IC50: 214 nM BRD3_BD2, IC50: 98 nM						98%
GSK620	✔						97%
Thalidomide-NH-C4-NH-Boc	✔						98%
Trotabresib	✔						99%
NHWD-870	✔						98%
CFT8634	++++ BRD9, DC50: 3 nM						98%
GSK2801		++ BAZ2A, Kd: 257 nM BAZ2B, Kd: 136 nM					99%+
KG-501		✔					99%+
UNC 669		+ L3MBTL4, IC50: 6 μM L3MBTL3, IC50: 35 μM					98%
PFI-3		+++ SMARCA2A, Kd: 72 nM SMARCA4, Kd: 55 nM					99%+
UNC1215		+++ L3MBTL3- D274A, IC50: 3.5 μM L3MBTL3, IC50: 120 nM					99%+
EED226		++ EED, Kd: 82 nM PRC2, Kd: 114 nM					99%+
BRD9539		✔					98%
UNC926		+ L3MBTL1, Kd: 3.9 μM					99%
666-15		++ CREB, IC50: 81 nM					99%+
UNC6852		+ EED, IC50: 247 nM					98%
BAZ1A-IN-1		+ BAZ1A, Kd: 0.52 μM					99%+
PFI-4			++ BRPF2, IC50: 7.9 μM BRPF1, IC50: 80 nM				99%+
OF-1			++ BRPF2, Kd: 500 nM BRPF1B, Kd: 100 nM				99%+
GSK-5959			++ BRPF3, pIC50: 7.1 BRPF2, pIC50: 5.2				99%
GSK6853			++++ BRPF1, pIC50: 8.1				99%+
NI-42			++++ BRPF1, IC50: 48 nM BRPF3, IC50: 260 nM				99%+
E-7386				+++ CBP/beta-catenin, IC50: 0.0484 μM			97%
I-CBP112					++ CBP, Kd: 151 nM p300, Kd: 167 nM		98+%
Histone Acetyltransferase Inhibitor II					+ p300, IC50: 5 μM		98%
C646					+ p300/CBP, Ki: 400 nM		99%+
Anacardic Acid					+ PCAF, IC50: 5 μM p300/CBP, IC50: 8.5 μM		99%+
SGC-CBP30					++++ EP300, IC50: 38 nM CREBBP, IC50: 21 nM		99%+
Nordihydroguaiaretic acid					✔	HER2,IGF-1R	99%+
Curcumin					+ p300, IC50: ~25 μM	Nrf2,Ferroptosis,NF-κB	98%
PF-CBP1 HCl					++ p300/CBP, IC50: 363nM CREBBP, IC50: 125nM		97%
CPI-637					+++ CBP, IC50: 0.03 μM EP300, IC50: 0.051 μM		99%+
Foscenvivint					✔	β-catenin	99%+
A-485					++ p300 HAT, IC50: 0.06 μM		99%+
GNE-781	+ BRD4(1), IC50: 5100 nM				++++ CBP, IC50: 0.94 nM		98%
NEO2734	+++ BET, IC50: <30 nM				+++ p300/CBP, IC50: <30 nM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	PLK1 ↓ ↑	PLK2 ↓ ↑	PLK3 ↓ ↑	PLK4 ↓ ↑	其他靶点	纯度
HMN-214	✔					99%+
SBE13 HCl	++++ PLK1, IC50: 200 pM					98%
Onvansertib	+++ PLK1, IC50: 2 nM					99%+
Volasertib	++++ PLK1, IC50: 0.87 nM					98%
GSK461364	+++ PLK1, Ki: 2.2 nM					99%+
MLN0905	+++ PLK1, IC50: 2 nM					99%+
Ro3280	++ PLK1, IC50: 3 nM					99%
(E/Z)-Rigosertib sodium	+ PLK1, IC50: 9 nM	+ PLK2, IC50: 260 nM			Bcr-Abl	99%+
BI 2536	++++ PLK1, IC50: 0.83 nM	++ PLK2, IC50: 3.5 nM	+ PLK3, IC50: 9.0 nM			99%+
CFI-400945				++ PLK4, IC50: 2.8 nM	Tie-2	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

BI 2536 生物活性

靶点	BET BRD4, Kd:37 nM PLK2 PLK2, IC50:3.5 nM PLK3 PLK3, IC50:9.0 nM PLK1 PLK1, IC50:0.83 nM
描述	Polo-like kinase 1 (Plk1) is a serine/theonin-specific kinase that regulates multiple stages during mitotic progression and acts as a negative prognostic marker in different types of human cancers. BI-2536 is a Plk1 inhibitor that blocks human Plk1 with an IC50 value of 0.83 nM. It also inhibits the activities of Plk2 and Plk3 with IC50 values of 3.5 nM and 9.0 nM, respectively. Accumulated 4N DNA content was observed in HeLa-S3 cells treated by BI-2536 (10 nM – 1 μM) for 24 hours, indicating a blockage of cell-cycle. When HeLa cells synchronized at the G1/S transition were treated with 60 nM BI-2536, cells released into median progressed through S phase normally followed by the G2/M arrest. In hTERT-RPE1 cells treated by BI-2536 (100 nM), nearly 70% of mitotic cells demonstrated a typical “Polo” phenotype. Intravenous injection of BI-2536 (40 – 50 mg/kg, once or twice/week) for 20 - 30 days inhibited the growth of HCT 116 tumor xenografts in immunodeficient, nu/nu mice. In a more rigorous xenograft model of larger HCT 116 tumors, 5 cycles of BI-2536 (50 mg/kg, twice weekly on two consecutive days) efficiently induced tumor regressions compared to control mice. In addition, four to seven cycles of BI-2536 (50 mg/kg, twice weekly on two consecutive days) also inhibited tumor growth in BxPC-3 and A549 xenograft models with T/C values of 5% and 14%, respectively. BI-2536 also inhibited the growth of NCI-H460 lung carcinomas, increased mitotic index and histone H3 phosphorylation in nu/nu mice)^[3].
作用机制	BI-2536 is derived from a chemical series, the dihydro-pteridinones, and functions as an ATP-competitive inhibitor for Plk1^[3].

BI 2536 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
5637		Growth Inhibition Assay		IC50=45.47 nM	23792639
697		Growth Inhibition Assay		IC50=0.01668 μM	SANGER
697		Growth Inhibition Assay	24 h	IC50=2107.1 nM	24519995
697		Growth Inhibition Assay	48 h	IC50=305.3 nM	24519995

BI 2536 动物研究

Dose	Nude Mice: 40 mg/kg - 50 mg/kg^[3] (i.v.); 10 mg/kg, 20 mg/kg^[4] (i.p.)
Administration	i.v., i.p.

BI 2536 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00526149	Breast Cancer ... 展开 >> Endometrial Cancer Head and Neck Cancer Melanoma (Skin) Ovarian Cancer Sarcoma 收起 <<	Phase 2	Completed	-	Belgium ... 展开 >> U.Z. Gasthuisberg Leuven, Belgium, B-3000 收起 <<
NCT00710710	Pancreatic Neoplasms	Phase 2	Completed	-	Austria ... 展开 >> 1216.10.43001 Boehringer Ingelheim Investigational Site Wien, Austria Germany 1216.10.49013 Boehringer Ingelheim Investigational Site Celle, Germany 1216.10.49009 Boehringer Ingelheim Investigational Site Düsseldorf, Germany 1216.10.49007 Boehringer Ingelheim Investigational Site Essen, Germany 1216.10.49001 Boehringer Ingelheim Investigational Site Freiburg/Breisgau, Germany 1216.10.49005 Boehringer Ingelheim Investigational Site Hamburg, Germany 1216.10.49010 Boehringer Ingelheim Investigational Site Herne, Germany 1216.10.49008 Boehringer Ingelheim Investigational Site München, Germany 1216.10.49003 Boehringer Ingelheim Investigational Site Stuttgart, Germany 1216.10.49002 Boehringer Ingelheim Investigational Site Ulm, Germany 收起 <<
NCT00412880	Carcinoma, Small Cell	Phase 2	Completed	-	United States, Arkansas ... 展开 >> 1216.11.007 Boehringer Ingelheim Investigational Site Fayetteville, Arkansas, United States United States, Illinois 1216.11.003 Boehringer Ingelheim Investigational Site Chicago, Illinois, United States 1216.11.006 Boehringer Ingelheim Investigational Site Evanston, Illinois, United States United States, Massachusetts 1216.11.002 Boehringer Ingelheim Investigational Site Boston, Massachusetts, United States United States, Missouri 1216.11.005 Boehringer Ingelheim Investigational Site St. Louis, Missouri, United States United States, North Carolina 1216.11.001 Boehringer Ingelheim Investigational Site Chapel Hill, North Carolina, United States United States, South Carolina 1216.11.011 Boehringer Ingelheim Investigational Site Charleston, South Carolina, United States 1216.11.010 Boehringer Ingelheim Investigational Site Greenville, South Carolina, United States United States, Washington 1216.11.012 Boehringer Ingelheim Investigational Site Seattle, Washington, United States Canada, Alberta 1216.11.009 Alberta Cancer Board Edmonton, Alberta, Canada 收起 <<

BI 2536 参考文献

[1]17(4):316-22.

BI 2536 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.58mL

1.92mL

0.96mL

19.17mL

3.83mL

1.92mL

BI 2536 技术信息

CAS号	755038-02-9
分子式	C₂₈H₃₉N₇O₃
分子量	521.654

别名
运输	蓝冰

存储条件

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 65 mg/mL(124.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

0.1 M HCL: 25 mg/mL(47.92 mM)，配合低频超声，并调节pH至4

动物实验配方

5%DMSO+40%PEG300+5%Tween80+50%water 12.5 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

5637		Growth Inhibition Assay		IC50=45.47 nM	23792639
697		Growth Inhibition Assay		IC50=0.01668 μM	SANGER
697		Growth Inhibition Assay	24 h	IC50=2107.1 nM	24519995
697		Growth Inhibition Assay	48 h	IC50=305.3 nM	24519995
697		Growth Inhibition Assay	72 h	IC50=74.28 nM	24519995
786-O	5-80 nM	Growth Inhibition Assay	96 h	suppresses the proliferation in a dose-dependent manner with IC50 values of 2 to 20 nM	21642374
8505C	0.1-100 nM	Growth Inhibition Assay	72 h	EC50=3.2 nM	19223553
8-MG-BA		Growth Inhibition Assay		IC50=0.05851 μM	SANGER
A101D		Growth Inhibition Assay		IC50=0.03748 μM	SANGER
A253		Growth Inhibition Assay		IC50=0.08822 μM	SANGER
A388		Growth Inhibition Assay		IC50=0.02227 μM	SANGER
A3-KAW		Growth Inhibition Assay		IC50=0.25341 μM	SANGER
A498		Growth Inhibition Assay		IC50=6.87192 μM	SANGER
A498	5-80 nM	Growth Inhibition Assay	96 h	suppresses the proliferation in a dose-dependent manner with IC50 values of 2 to 20 nM	21642374
A4-Fuk		Growth Inhibition Assay		IC50=0.02218 μM	SANGER
A704		Growth Inhibition Assay		IC50=3.14194 μM	SANGER
ACHN	5-80 nM	Growth Inhibition Assay	96 h	suppresses the proliferation in a dose-dependent manner with IC50 values of 2 to 20 nM	21642374
ACN		Growth Inhibition Assay		IC50=0.00843 μM	SANGER
ACT-1	0.1-100 nM	Growth Inhibition Assay	72 h	EC50=5.4 nM	19223553
ALL-PO		Growth Inhibition Assay		IC50=0.013 μM	SANGER
ARH-77		Growth Inhibition Assay		IC50=0.17379 μM	SANGER
ATN-1		Growth Inhibition Assay		IC50=0.06345 μM	SANGER
AU565	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
BB30-HNC		Growth Inhibition Assay		IC50=0.06436 μM	SANGER
BB49-HNC		Growth Inhibition Assay		IC50=9.42265 μM	SANGER
BB65-RCC		Growth Inhibition Assay		IC50=0.10294 μM	SANGER
BC-1		Growth Inhibition Assay		IC50=0.22616 μM	SANGER
BC-3		Growth Inhibition Assay		IC50=0.09662 μM	SANGER
BE-13		Growth Inhibition Assay		IC50=0.0274 μM	SANGER
Becker		Growth Inhibition Assay		IC50=0.03555 μM	SANGER
BL-41		Growth Inhibition Assay		IC50=0.04125 μM	SANGER
BL-70		Growth Inhibition Assay		IC50=0.02857 μM	SANGER
BOKU		Growth Inhibition Assay		IC50=0.43792 μM	SANGER
BT-474		Growth Inhibition Assay		IC50=0.88854 μM	SANGER
BT-474-M1	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
BV-173		Growth Inhibition Assay		IC50=0.11243 μM	SANGER
C2	1-1000 nM	Growth Inhibition Assay	72 h	inhibits the cell proliferation in a dose-dependent manne	21242189
C2BBe1		Growth Inhibition Assay		IC50=11.3523 μM	SANGER
C4-2		Growth Inhibition Assay		IC50=8 nM	25505174
C8166		Growth Inhibition Assay		IC50=13.8303 μM	SANGER
CA46		Growth Inhibition Assay		IC50=2.75967 μM	SANGER
Caki-1	5-80 nM	Growth Inhibition Assay	96 h	suppresses the proliferation in a dose-dependent manner with IC50 values of 2 to 20 nM	21642374
CAL-148		Growth Inhibition Assay		IC50=0.14483 μM	SANGER
CAL62	0.1-100 nM	Growth Inhibition Assay	72 h	EC50=1.4 nM	19223553
Calu-6		Growth Inhibition Assay		IC50=0.09598 μM	SANGER
CAS-1		Growth Inhibition Assay		IC50=1.34231 μM	SANGER
CB1117		Growth Inhibition Assay		IC50=15.6 nM	24204733
CB660		Growth Inhibition Assay		IC50=6.4 nM	24204733
CC-LP-1		Growth Inhibition Assay	72 h	IC50=5.84 nM	21965739
CCRF-CEM		Growth Inhibition Assay		IC50=0.02543 μM	SANGER
CC-SW-1		Growth Inhibition Assay	72 h	IC50=9.55 nM	21965739
CEM		Growth Inhibition Assay	24 h	IC50=52.18 nM	24519995
CEM		Growth Inhibition Assay	48 h	IC50=24.55 nM	24519995
CEM		Growth Inhibition Assay	72 h	IC50=5.42 nM	24519995
CESS		Growth Inhibition Assay		IC50=0.01602 μM	SANGER
CGTH-W-1		Growth Inhibition Assay		IC50=0.60755 μM	SANGER
CHP-126		Growth Inhibition Assay		IC50=1.16199 μM	SANGER
CHP-212	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
CMK		Growth Inhibition Assay		IC50=0.08225 μM	SANGER
COLO-320-HSR		Growth Inhibition Assay		IC50=0.18154 μM	SANGER
COLO-668		Growth Inhibition Assay		IC50=0.45668 μM	SANGER
COLO-684		Growth Inhibition Assay		IC50=0.15721 μM	SANGER
COLO-800		Growth Inhibition Assay		IC50=40.0773 μM	SANGER
COLO-824		Growth Inhibition Assay		IC50=34.1006 μM	SANGER
COLO-829		Growth Inhibition Assay		IC50=6.33359 μM	SANGER
CORL-23/P		Growth Inhibition Assay		IC50=4.38 ± 1.25 nM	23962445
CORL-23/R		Growth Inhibition Assay		IC50=5.16 ± 1.83 nM	23962445
COR-L279		Growth Inhibition Assay		IC50=0.09556 μM	SANGER
COR-L88		Growth Inhibition Assay		IC50=0.14802 μM	SANGER
CP66-MEL		Growth Inhibition Assay		IC50=0.31878 μM	SANGER
CP67-MEL		Growth Inhibition Assay		IC50=0.67596 μM	SANGER
CPC-N		Growth Inhibition Assay		IC50=0.06524 μM	SANGER
CTB-1		Growth Inhibition Assay		IC50=0.24493 μM	SANGER
CTV-1		Growth Inhibition Assay		IC50=0.05502 μM	SANGER
D-247MG		Growth Inhibition Assay		IC50=0.73232 μM	SANGER
D-263MG		Growth Inhibition Assay		IC50=0.94512 μM	SANGER
D-336MG		Growth Inhibition Assay		IC50=0.61791 μM	SANGER
D-502MG		Growth Inhibition Assay		IC50=7.9836 μM	SANGER
Daoy	1.875-240 nM	Growth Inhibition Assay	72 h	IC50=5 nM	22390279
Daudi		Growth Inhibition Assay		IC50=0.08256 μM	SANGER
DB		Growth Inhibition Assay		IC50=3.25576 μM	SANGER
DEL		Growth Inhibition Assay		IC50=0.05709 μM	SANGER
DG-75		Growth Inhibition Assay		IC50=0.08922 μM	SANGER
DJM-1		Growth Inhibition Assay		IC50=0.05142 μM	SANGER
DMS-114		Growth Inhibition Assay		IC50=0.07528 μM	SANGER
DMS-153		Growth Inhibition Assay		IC50=1.57674 μM	SANGER
DMS-79		Growth Inhibition Assay		IC50=7.04512 μM	SANGER
DOHH-2		Growth Inhibition Assay		IC50=0.17672 μM	SANGER
DSH1		Growth Inhibition Assay		IC50=0.38631 μM	SANGER
DU145		Growth Inhibition Assay		IC50∼60 nM	23884428
DU-4475		Growth Inhibition Assay		IC50=0.10407 μM	SANGER
EB2		Growth Inhibition Assay		IC50=12.6881 μM	SANGER
EB-3		Growth Inhibition Assay		IC50=0.61153 μM	SANGER
ECC4		Growth Inhibition Assay		IC50=6.82179 μM	SANGER
EC-GI-10		Growth Inhibition Assay		IC50=0.32987 μM	SANGER
EGI-1		Growth Inhibition Assay	72 h	IC50=10.72 nM	21965739
EHEB		Growth Inhibition Assay		IC50=0.71854 μM	SANGER
EKVX		Growth Inhibition Assay		IC50=0.79073 μM	SANGER
EM-2		Growth Inhibition Assay		IC50=0.15467 μM	SANGER
EoL-1-cell		Growth Inhibition Assay		IC50=0.11672 μM	SANGER
ES1		Growth Inhibition Assay		IC50=9.68956 μM	SANGER
ES3		Growth Inhibition Assay		IC50=13.9977 μM	SANGER
ES4		Growth Inhibition Assay		IC50=0.03463 μM	SANGER
ES5		Growth Inhibition Assay		IC50=21.7671 μM	SANGER
ES6		Growth Inhibition Assay		IC50=0.02881 μM	SANGER
ES7		Growth Inhibition Assay		IC50=19.5507 μM	SANGER
ES8		Growth Inhibition Assay		IC50=0.01494 μM	SANGER
ETK-1		Growth Inhibition Assay		IC50=0.02736 μM	SANGER
EVSA-T		Growth Inhibition Assay		IC50=0.20312 μM	SANGER
EW-1		Growth Inhibition Assay		IC50=0.05837 μM	SANGER
EW-13		Growth Inhibition Assay		IC50=3.83417 μM	SANGER
EW-16		Growth Inhibition Assay		IC50=0.01336 μM	SANGER
EW-24		Growth Inhibition Assay		IC50=0.92002 μM	SANGER
EW-3		Growth Inhibition Assay		IC50=0.12893 μM	SANGER
G166		Growth Inhibition Assay		IC50=7.0 nM	24204733
G7		Growth Inhibition Assay		IC50=3.3 nM	24204733
GAK		Growth Inhibition Assay		IC50=0.21189 μM	SANGER
GB-1		Growth Inhibition Assay		IC50=0.14526 μM	SANGER
GBC		Growth Inhibition Assay	72 h	IC50=14.78 nM	21965739
GB-CL-1		Growth Inhibition Assay	72 h	IC50=5.22 nM	21965739
GCIY		Growth Inhibition Assay		IC50=0.70363 μM	SANGER
GDM-1		Growth Inhibition Assay		IC50=0.33059 μM	SANGER
GI-1		Growth Inhibition Assay		IC50=0.01383 μM	SANGER
GI-ME-N		Growth Inhibition Assay		IC50=0.07286 μM	SANGER
GOTO		Growth Inhibition Assay		IC50=0.42118 μM	SANGER
GR-ST		Growth Inhibition Assay		IC50=0.21488 μM	SANGER
GT3TKB		Growth Inhibition Assay		IC50=0.02953 μM	SANGER
H-1		Growth Inhibition Assay	72 h	IC50=9.54 nM	21965739
HAL-01		Growth Inhibition Assay		IC50=0.99872 μM	SANGER
HC-1		Growth Inhibition Assay		IC50=0.05597 μM	SANGER
HCC1187		Growth Inhibition Assay		IC50=3.78315 μM	SANGER
HCC1599		Growth Inhibition Assay		IC50=0.04258 μM	SANGER
HCC2157		Growth Inhibition Assay		IC50=0.84951 μM	SANGER
HCC2218		Growth Inhibition Assay		IC50=0.79131 μM	SANGER
HCE-4		Growth Inhibition Assay		IC50=0.02682 μM	SANGER
HCE-T		Growth Inhibition Assay		IC50=0.16504 μM	SANGER
HCT116p53(-/-)	10-1000 nM	Growth Inhibition Assay	24/48 h	inhibits cell proliferation completely at 25 nM	22262171
HCT116p53(+/+)	10-1000 nM	Growth Inhibition Assay	24/48 h	inhibits cell proliferation completely at 25 nM	22262171
HDLM-2		Growth Inhibition Assay		IC50=0.37814 μM	SANGER
HD-MY-Z		Growth Inhibition Assay		IC50=0.10856 μM	SANGER
Hec50co		Growth Inhibition Assay		IC50=5 nM	23146687
HEL		Growth Inhibition Assay		IC50=0.08668 μM	SANGER
HeLa	10-100 nM	Growth Inhibition Assay	48 h	IC50=52.9 nM	22080235
HeLa	10-100 nM	Growth Inhibition Assay	72 h	IC50=50.5 nM	22080235
HH		Growth Inhibition Assay		IC50=0.21405 μM	SANGER
HL-60		Growth Inhibition Assay		IC50=1.99908 μM	SANGER
HMC-1.1	1-1000 nM	Growth Inhibition Assay	72 h	inhibits the cell proliferation in a dose-dependent manne	21242189
HMC-1.2	1-1000 nM	Growth Inhibition Assay	72 h	inhibits the cell proliferation in a dose-dependent manne	21242189
HOP-62		Growth Inhibition Assay		IC50=0.0242 μM	SANGER
HR5	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
HT		Growth Inhibition Assay		IC50=0.13574 μM	SANGER
HT-144		Growth Inhibition Assay		IC50=0.0613 μM	SANGER
HuH-28		Growth Inhibition Assay	72 h	IC50=11.19 nM	21965739
Huh-7	1/10/100/1000 nM	Growth Inhibition Assay	48 h	decreases the cell viability dose-dependently	22745587
HUTU-80		Growth Inhibition Assay		IC50=0.02624 μM	SANGER
IA-LM		Growth Inhibition Assay		IC50=0.01688 μM	SANGER
IMR-32	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
IMR-5		Growth Inhibition Assay		IC50=0.05021 μM	SANGER
IST-MEL1		Growth Inhibition Assay		IC50=0.04442 μM	SANGER
IST-MES1		Growth Inhibition Assay		IC50=0.29238 μM	SANGER
IST-SL1		Growth Inhibition Assay		IC50=0.34914 μM	SANGER
IST-SL2		Growth Inhibition Assay		IC50=0.07004 μM	SANGER
JAR		Growth Inhibition Assay		IC50=0.10925 μM	SANGER
JiyoyeP-2003		Growth Inhibition Assay		IC50=0.20477 μM	SANGER
J-RT3-T3-5		Growth Inhibition Assay		IC50=0.44878 μM	SANGER
JURKAT		Growth Inhibition Assay	24 h	IC50=416.66 nM	24519995
JURKAT		Growth Inhibition Assay	48 h	IC50=14.84 nM	24519995
JURKAT		Growth Inhibition Assay	72 h	IC50=3.65 nM	24519995
JVM-2		Growth Inhibition Assay		IC50=2.06135 μM	SANGER
JVM-3		Growth Inhibition Assay		IC50=1.47855 μM	SANGER
K052		Growth Inhibition Assay		IC50=0.11712 μM	SANGER
K5		Growth Inhibition Assay		IC50=0.26984 μM	SANGER
K-562		Growth Inhibition Assay		IC50=0.10858 μM	SANGER
KALS-1		Growth Inhibition Assay		IC50=0.02338 μM	SANGER
KARPAS-299		Growth Inhibition Assay		IC50=0.19241 μM	SANGER
KARPAS-422		Growth Inhibition Assay		IC50=0.25435 μM	SANGER
KARPAS-45		Growth Inhibition Assay		IC50=0.05358 μM	SANGER
KB-3-1		Growth Inhibition Assay		IC50=1.48 ± 0.53 nM	23962445
KB-8-5-11		Growth Inhibition Assay		IC50=5.01 ± 2.01 nM	23962445
KB-C-1		Growth Inhibition Assay		IC50=16.76 ± 4.51 nM	23962445
KB-V1		Growth Inhibition Assay		IC50=3.92 μM	23593196
KB-V-1		Growth Inhibition Assay		IC50=281.24 ± 31.57 nM	23962445
KE-37		Growth Inhibition Assay		IC50=0.02741 μM	SANGER
Kelly	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
KG1	1/10/100 nM	Growth Inhibition Assay	72 h	inhibits the cell proliferation in both time- and dose-dependent manne	19458358
KG-1		Growth Inhibition Assay		IC50=40.8955 μM	SANGER
KGN		Growth Inhibition Assay		IC50=0.08759 μM	SANGER
KINGS-1		Growth Inhibition Assay		IC50=0.1591 μM	SANGER
KLE		Growth Inhibition Assay		IC50=0.52171 μM	SANGER
KM12		Growth Inhibition Assay		IC50=0.01348 μM	SANGER
KM-H2		Growth Inhibition Assay		IC50=0.06221 μM	SANGER
KMOE-2		Growth Inhibition Assay		IC50=0.35175 μM	SANGER
KNS-42		Growth Inhibition Assay		IC50=0.08161 μM	SANGER
KNS-81-FD		Growth Inhibition Assay		IC50=0.81011 μM	SANGER
KP-N-RT-BM-1		Growth Inhibition Assay		IC50=0.13612 μM	SANGER
KP-N-YS		Growth Inhibition Assay		IC50=0.04085 μM	SANGER
KS-1		Growth Inhibition Assay		IC50=0.06748 μM	SANGER
KU812		Growth Inhibition Assay		IC50=0.12044 μM	SANGER
KURAMOCHI		Growth Inhibition Assay		IC50=0.02285 μM	SANGER
KY821		Growth Inhibition Assay		IC50=0.05632 μM	SANGER
L-363		Growth Inhibition Assay		IC50=0.11079 μM	SANGER
L-428		Growth Inhibition Assay		IC50=0.18813 μM	SANGER
L-540		Growth Inhibition Assay		IC50=0.10708 μM	SANGER
LAMA-84		Growth Inhibition Assay		IC50=0.13187 μM	SANGER
LAN-6		Growth Inhibition Assay		IC50=0.31572 μM	SANGER
LB1047-RCC		Growth Inhibition Assay		IC50=0.2441 μM	SANGER
LB2241-RCC		Growth Inhibition Assay		IC50=0.52525 μM	SANGER
LB2518-MEL		Growth Inhibition Assay		IC50=0.49703 μM	SANGER
LB373-MEL-D		Growth Inhibition Assay		IC50=0.39197 μM	SANGER
LB647-SCLC		Growth Inhibition Assay		IC50=0.03195 μM	SANGER
LB771-HNC		Growth Inhibition Assay		IC50=0.05979 μM	SANGER
LB831-BLC		Growth Inhibition Assay		IC50=0.08561 μM	SANGER
LB996-RCC		Growth Inhibition Assay		IC50=1.08051 μM	SANGER
LC-1F		Growth Inhibition Assay		IC50=0.62592 μM	SANGER
LC-2-ad		Growth Inhibition Assay		IC50=0.01093 μM	SANGER
LC4-1		Growth Inhibition Assay		IC50=0.19502 μM	SANGER
LNCaP		Growth Inhibition Assay		IC50=91.3 nM	25505174
LNCaP		Growth Inhibition Assay		IC50∼75 nM	23884428
LNCaP-Clone-FGC		Growth Inhibition Assay		IC50=41.9017 μM	SANGER
LOUCY		Growth Inhibition Assay		IC50=0.0205 μM	SANGER
LOXIMVI		Growth Inhibition Assay		IC50=0.16949 μM	SANGER
LP-1		Growth Inhibition Assay		IC50=0.1424 μM	SANGER
LS-1034		Growth Inhibition Assay		IC50=0.38954 μM	SANGER
LS-123		Growth Inhibition Assay		IC50=0.15917 μM	SANGER
LS-411N		Growth Inhibition Assay		IC50=0.01407 μM	SANGER
LS-513		Growth Inhibition Assay		IC50=0.67259 μM	SANGER
LU-134-A		Growth Inhibition Assay		IC50=0.08708 μM	SANGER
LU-139		Growth Inhibition Assay		IC50=0.04442 μM	SANGER
LU-165		Growth Inhibition Assay		IC50=1.86476 μM	SANGER
LU-65		Growth Inhibition Assay		IC50=4.93033 μM	SANGER
LXF-289		Growth Inhibition Assay		IC50=0.0177 μM	SANGER
MC116		Growth Inhibition Assay		IC50=0.16158 μM	SANGER
MC-CAR		Growth Inhibition Assay		IC50=3.54817 μM	SANGER
MCF10A	1/5/10 nM	Apoptosis Assay	24/48/72 h	induces apoptosis in a dose-dependent manner	23144294
MCF7		Growth Inhibition Assay		IC50=5.11 ± 1.47 nM	23962445
MCF7	100 nM	Function Assay	1 h	reduces the induction of Greb1, Sgk1, Ps2, Serpina3, and Wisp2	23770244
MCF7	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
MCF7-FLV1000		Growth Inhibition Assay		IC50=393.18 ± 74.83 nM	23962445
MDA-MB-134-VI		Growth Inhibition Assay		IC50=0.50921 μM	SANGER
MDA-MB-231	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
MDA-MB-468	1/5/10 nM	Apoptosis Assay	24/48/72 h	induces apoptosis in a dose-dependent manner	23144294
MDR19-HEK293		Growth Inhibition Assay		IC50=85.50 ± 13.67 nM	23962445
MEG-01		Growth Inhibition Assay		IC50=0.25673 μM	SANGER
MFH-ino		Growth Inhibition Assay		IC50=0.05003 μM	SANGER
MFM-223		Growth Inhibition Assay		IC50=10.9927 μM	SANGER
MHH-CALL-2		Growth Inhibition Assay		IC50=6.51508 μM	SANGER
MHH-NB-11		Growth Inhibition Assay		IC50=0.63801 μM	SANGER
MHH-PREB-1		Growth Inhibition Assay		IC50=0.06319 μM	SANGER
ML-2		Growth Inhibition Assay		IC50=0.05414 μM	SANGER
MLMA		Growth Inhibition Assay		IC50=0.14167 μM	SANGER
MMAC-SF		Growth Inhibition Assay		IC50=2.86628 μM	SANGER
MN-60		Growth Inhibition Assay		IC50=2.17308 μM	SANGER
MOLT-13		Growth Inhibition Assay		IC50=0.04238 μM	SANGER
MOLT-16		Growth Inhibition Assay		IC50=0.08121 μM	SANGER
MOLT-4		Growth Inhibition Assay		IC50=0.08983 μM	SANGER
MOLT-4		Growth Inhibition Assay	24 h	IC50=2853.5 nM	24519995
MOLT-4		Growth Inhibition Assay	48 h	IC50=26.6 nM	24519995
MOLT-4		Growth Inhibition Assay	72 h	IC50=7.39 nM	24519995
MONO-MAC-6		Growth Inhibition Assay		IC50=0.07986 μM	SANGER
Mo-T		Growth Inhibition Assay		IC50=17.4029 μM	SANGER
MPP-89		Growth Inhibition Assay		IC50=0.75978 μM	SANGER
MRK-nu-1		Growth Inhibition Assay		IC50=0.42205 μM	SANGER
MRP1-HEK293		Growth Inhibition Assay		IC50=2.99 ± 1.49 nM	23962445
MS-1		Growth Inhibition Assay		IC50=0.04701 μM	SANGER
MSTO-211H		Growth Inhibition Assay		IC50=21.8858 μM	SANGER
MV-4-11		Growth Inhibition Assay		IC50=0.30788 μM	SANGER
MZ1-PC		Growth Inhibition Assay		IC50=0.04127 μM	SANGER
MZ2-MEL		Growth Inhibition Assay		IC50=0.1105 μM	SANGER
MZ7-mel		Growth Inhibition Assay		IC50=0.12237 μM	SANGER
Mz-ChA-2		Growth Inhibition Assay	72 h	IC50=3.31 nM	21965739
NALM-16		Growth Inhibition Assay	24 h	IC50=96.28 nM	24519995
NALM-16		Growth Inhibition Assay	48 h	IC50=63.24 nM	24519995
NALM-16		Growth Inhibition Assay	72 h	IC50=77.73 nM	24519995
NALM-6		Growth Inhibition Assay		IC50=0.05973 μM	SANGER
NALM-6		Growth Inhibition Assay	24 h	IC50=34330 nM	24519995
NALM-6		Growth Inhibition Assay	48 h	IC50=23.26 nM	24519995
NALM-6		Growth Inhibition Assay	72 h	IC50=1.78 nM	24519995
NB1		Growth Inhibition Assay		IC50=0.06613 μM	SANGER
NB10		Growth Inhibition Assay		IC50=30.2694 μM	SANGER
NB13		Growth Inhibition Assay		IC50=0.03316 μM	SANGER
NB14		Growth Inhibition Assay		IC50=5.97135 μM	SANGER
NB17		Growth Inhibition Assay		IC50=0.05207 μM	SANGER
NB5		Growth Inhibition Assay		IC50=0.15462 μM	SANGER
NB6		Growth Inhibition Assay		IC50=0.18566 μM	SANGER
NB69		Growth Inhibition Assay		IC50=1.26148 μM	SANGER
NB7		Growth Inhibition Assay		IC50=17.7467 μM	SANGER
NCCIT		Growth Inhibition Assay		IC50=0.13939 μM	SANGER
NCI-ADR-RES		Growth Inhibition Assay		IC50=1273.30 ± 191.20 nM	23962445
NCI-H1092		Growth Inhibition Assay		IC50=1.76182 μM	SANGER
NCI-H1155		Growth Inhibition Assay		IC50=1.73676 μM	SANGER
NCI-H1304		Growth Inhibition Assay		IC50=0.10594 μM	SANGER
NCI-H1355		Growth Inhibition Assay		IC50=0.02783 μM	SANGER
NCI-H1395		Growth Inhibition Assay		IC50=1.1067 μM	SANGER
NCI-H1417		Growth Inhibition Assay		IC50=0.53435 μM	SANGER
NCI-H1436		Growth Inhibition Assay		IC50=0.21464 μM	SANGER
NCI-H1522		Growth Inhibition Assay		IC50=0.59383 μM	SANGER
NCI-H1581		Growth Inhibition Assay		IC50=0.07478 μM	SANGER
NCI-H1648		Growth Inhibition Assay		IC50=0.02647 μM	SANGER
NCI-H1650		Growth Inhibition Assay		IC50=16.3765 μM	SANGER
NCI-H1694		Growth Inhibition Assay		IC50=0.08744 μM	SANGER
NCI-H1770		Growth Inhibition Assay		IC50=6.66904 μM	SANGER
NCI-H1838		Growth Inhibition Assay		IC50=38.3797 μM	SANGER
NCI-H187		Growth Inhibition Assay		IC50=0.07726 μM	SANGER
NCI-H1882		Growth Inhibition Assay		IC50=0.09809 μM	SANGER
NCI-H1963		Growth Inhibition Assay		IC50=0.01673 μM	SANGER
NCI-H2081		Growth Inhibition Assay		IC50=0.58611 μM	SANGER
NCI-H209		Growth Inhibition Assay		IC50=0.26374 μM	SANGER
NCI-H2107		Growth Inhibition Assay		IC50=1.01854 μM	SANGER
NCI-H2126		Growth Inhibition Assay		IC50=0.09791 μM	SANGER
NCI-H2141		Growth Inhibition Assay		IC50=0.19011 μM	SANGER
NCI-H2171		Growth Inhibition Assay		IC50=3.03448 μM	SANGER
NCI-H2196		Growth Inhibition Assay		IC50=0.97777 μM	SANGER
NCI-H226		Growth Inhibition Assay		IC50=4.33606 μM	SANGER
NCI-H23		Growth Inhibition Assay		IC50=2.80791 μM	SANGER
NCI-H322M		Growth Inhibition Assay		IC50=42.5984 μM	SANGER
NCI-H345		Growth Inhibition Assay		IC50=0.23805 μM	SANGER
NCI-H446		Growth Inhibition Assay		IC50=0.09462 μM	SANGER
NCI-H510A		Growth Inhibition Assay		IC50=0.08336 μM	SANGER
NCI-H524		Growth Inhibition Assay		IC50=0.11274 μM	SANGER
NCI-H526		Growth Inhibition Assay		IC50=0.1044 μM	SANGER
NCI-H64		Growth Inhibition Assay		IC50=0.16347 μM	SANGER
NCI-H69		Growth Inhibition Assay		IC50=0.64879 μM	SANGER
NCI-H719		Growth Inhibition Assay		IC50=3.30384 μM	SANGER
NCI-H720		Growth Inhibition Assay		IC50=0.20525 μM	SANGER
NCI-H747		Growth Inhibition Assay		IC50=0.137 μM	SANGER
NCI-H748		Growth Inhibition Assay		IC50=0.912 μM	SANGER
NCI-H82		Growth Inhibition Assay		IC50=0.03343 μM	SANGER
NCI-H889		Growth Inhibition Assay		IC50=0.59844 μM	SANGER
NCI-SNU-1		Growth Inhibition Assay		IC50=4.21999 μM	SANGER
NCI-SNU-16		Growth Inhibition Assay		IC50=0.10742 μM	SANGER
NCI-SNU-5		Growth Inhibition Assay		IC50=0.09258 μM	SANGER
NEC		Growth Inhibition Assay	72 h	IC50=9.98 nM	21965739
NEC8		Growth Inhibition Assay		IC50=0.10525 μM	SANGER
NH-12		Growth Inhibition Assay		IC50=33.2017 μM	SANGER
NIH3T3		Growth Inhibition Assay		IC50=40.60 ± 4.97 nM	23962445
NIH3T3-G185		Growth Inhibition Assay		IC50=2413.40 ± 423.66 nM	23962445
NKM-1		Growth Inhibition Assay		IC50=0.14906 μM	SANGER
NMC-G1		Growth Inhibition Assay		IC50=0.28217 μM	SANGER
no-10		Growth Inhibition Assay		IC50=0.05474 μM	SANGER
no-11		Growth Inhibition Assay		IC50=0.12869 μM	SANGER
NOMO-1		Growth Inhibition Assay		IC50=0.4386 μM	SANGER
NOS-1		Growth Inhibition Assay		IC50=0.02093 μM	SANGER
NTERA-S-cl-D1		Growth Inhibition Assay		IC50=0.03399 μM	SANGER
OCI-AML2		Growth Inhibition Assay		IC50=4.5523 μM	SANGER
OCUB-M		Growth Inhibition Assay		IC50=0.01826 μM	SANGER
OCUT-1	0.1-100 nM	Growth Inhibition Assay	72 h	EC50=2.3 nM	19223553
OMC-1		Growth Inhibition Assay		IC50=0.96373 μM	SANGER
ONS-76		Growth Inhibition Assay		IC50=0.09276 μM	SANGER
ONS-76	1.875-240 nM	Growth Inhibition Assay	72 h	IC50=7.5 nM	22390279
OPM-2		Growth Inhibition Assay		IC50=0.23882 μM	SANGER
OS-RC-2		Growth Inhibition Assay		IC50=0.35544 μM	SANGER
OVCAR-4		Growth Inhibition Assay		IC50=0.04059 μM	SANGER
OVCAR-8		Growth Inhibition Assay		IC50=7.19 ± 3.60 nM	23962445
P12		Growth Inhibition Assay	24 h	IC50=39.27 nM	24519995
P12		Growth Inhibition Assay	48 h	IC50=18.46 nM	24519995
P12		Growth Inhibition Assay	72 h	IC50=6.37 nM	24519995
P30-OHK		Growth Inhibition Assay		IC50=7.21906 μM	SANGER
PC3		Growth Inhibition Assay		IC50∼175 nM	23884428
pcDNA-HEK293		Growth Inhibition Assay		IC50=2.75 ± 0.67 nM	23962445
PF-382		Growth Inhibition Assay		IC50=0.04198 μM	SANGER
PSN1		Growth Inhibition Assay		IC50=0.00776 μM	SANGER
QIMR-WIL		Growth Inhibition Assay		IC50=0.27155 μM	SANGER
R482-HEK293		Growth Inhibition Assay		IC50=25.97 ± 4.95 nM	23962445
Raji		Growth Inhibition Assay		IC50=0.74989 μM	SANGER
Ramos-2G6-4C10		Growth Inhibition Assay		IC50=0.08225 μM	SANGER
RCC10RGB		Growth Inhibition Assay		IC50=8.0628 μM	SANGER
REB		Growth Inhibition Assay	72 h	IC50=13.51 nM	21965739
REH		Growth Inhibition Assay		IC50=2.00582 μM	SANGER
REH		Growth Inhibition Assay	24 h	IC50=287.68 nM	24519995
REH		Growth Inhibition Assay	48 h	IC50=44.71 nM	24519995
REH		Growth Inhibition Assay	72 h	IC50=16.01 nM	24519995
RH-1		Growth Inhibition Assay		IC50=0.31871 μM	SANGER
RKO		Growth Inhibition Assay		IC50=0.01987 μM	SANGER
RL		Growth Inhibition Assay		IC50=39.2477 μM	SANGER
RL95-2		Growth Inhibition Assay		IC50=0.01738 μM	SANGER
RPMI-6666		Growth Inhibition Assay		IC50=0.12743 μM	SANGER
RPMI-8226		Growth Inhibition Assay		IC50=0.12052 μM	SANGER
RPMI-8402		Growth Inhibition Assay		IC50=0.02508 μM	SANGER
RPMI-8866		Growth Inhibition Assay		IC50=4.36029 μM	SANGER
RS 4;11		Growth Inhibition Assay	24 h	IC50=519.05 nM	24519995
RS 4;11		Growth Inhibition Assay	48 h	IC50=164.28 nM	24519995
RS 4;11		Growth Inhibition Assay	72 h	IC50=4.38 nM	24519995
RS4-11		Growth Inhibition Assay		IC50=0.06304 μM	SANGER
RT4		Growth Inhibition Assay		IC50=27.21 nM	23792639
RXF393		Growth Inhibition Assay		IC50=0.06764 μM	SANGER
S1		Growth Inhibition Assay		IC50=24.30 ± 4.75 nM	23962445
S1-M1-80		Growth Inhibition Assay		IC50=261.06 ± 48.25 nM	23962445
SBC-1		Growth Inhibition Assay		IC50=0.265 μM	SANGER
SCC-15		Growth Inhibition Assay		IC50=2.2027 μM	SANGER
SCC-3		Growth Inhibition Assay		IC50=0.51873 μM	SANGER
SCH		Growth Inhibition Assay		IC50=0.66023 μM	SANGER
SCLC-21H		Growth Inhibition Assay		IC50=0.15702 μM	SANGER
SF126		Growth Inhibition Assay		IC50=0.25383 μM	SANGER
SF188	10-100 nM	Growth Inhibition Assay	24-96 h	inhibits cell growth in both time- and concentration- depedent manner	23887645
SF268		Growth Inhibition Assay		IC50=0.06286 μM	SANGER
SF539		Growth Inhibition Assay		IC50=0.48684 μM	SANGER
SH-4		Growth Inhibition Assay		IC50=0.15466 μM	SANGER
SH-EP	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
SHP-77		Growth Inhibition Assay		IC50=0.70734 μM	SANGER
SH-SY5Y	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
SIG-M5		Growth Inhibition Assay		IC50=0.22727 μM	SANGER
SIL-ALL		Growth Inhibition Assay	24 h	IC50=199.77 nM	24519995
SIL-ALL		Growth Inhibition Assay	48 h	IC50=74.62 nM	24519995
SIL-ALL		Growth Inhibition Assay	72 h	IC50=7.2 nM	24519995
SIMA		Growth Inhibition Assay		IC50=3.58416 μM	SANGER
SJSA-1		Growth Inhibition Assay		IC50=0.0552 μM	SANGER
Sk-ChA-1		Growth Inhibition Assay	72 h	IC50=17.2 nM	21965739
SK-LMS-1		Growth Inhibition Assay		IC50=0.05805 μM	SANGER
SKM-1		Growth Inhibition Assay		IC50=37.8422 μM	SANGER
SK-MEL-1		Growth Inhibition Assay		IC50=2.32047 μM	SANGER
SK-MEL-2		Growth Inhibition Assay		IC50=1.71789 μM	SANGER
SK-MM-2		Growth Inhibition Assay		IC50=0.43442 μM	SANGER
SK-N-AS	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
SK-N-BE	1-125 nM	Growth Inhibition Assay	24-120 h	inhibits the cell proliferation in both time- and dose-dependent manne	21169242
SK-N-DZ		Growth Inhibition Assay		IC50=5.63465 μM	SANGER
SK-NEP-1		Growth Inhibition Assay		IC50=0.03499 μM	SANGER
SK-N-FI		Growth Inhibition Assay		IC50=0.6391 μM	SANGER
SK-PN-DW		Growth Inhibition Assay		IC50=0.12287 μM	SANGER
SK-UT-1		Growth Inhibition Assay		IC50=0.03774 μM	SANGER
SN12C	5-80 nM	Growth Inhibition Assay	96 h	suppresses the proliferation in a dose-dependent manner with IC50 values of 2 to 20 nM	21642374
SNB75		Growth Inhibition Assay		IC50=0.18824 μM	SANGER
SNU-C1		Growth Inhibition Assay		IC50=2.21343 μM	SANGER
SNU-C2B		Growth Inhibition Assay		IC50=0.01526 μM	SANGER
SR		Growth Inhibition Assay		IC50=0.12441 μM	SANGER
ST486		Growth Inhibition Assay		IC50=0.03337 μM	SANGER
SU-DHL-1		Growth Inhibition Assay		IC50=0.16206 μM	SANGER
SUM 149	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
SW1736	0.1-100 nM	Growth Inhibition Assay	72 h	EC50=5.6 nM	19223553
SW684		Growth Inhibition Assay		IC50=0.30047 μM	SANGER
SW872		Growth Inhibition Assay		IC50=3.78101 μM	SANGER
SW954		Growth Inhibition Assay		IC50=0.01705 μM	SANGER
SW962		Growth Inhibition Assay		IC50=0.07839 μM	SANGER
SW982		Growth Inhibition Assay		IC50=0.0379 μM	SANGER
T24		Growth Inhibition Assay		IC50=79.12 nM	23792639
T47D	0-100 nM	Growth Inhibition Assay	72 h	inhibits the cell viability in a dose-dependent mannar	22309939
T98G	10-100 nM	Growth Inhibition Assay	24-96 h	inhibits cell growth in concentration- depedent manner	23887645
TALL-1		Growth Inhibition Assay		IC50=0.05708 μM	SANGER
TE-1		Growth Inhibition Assay		IC50=0.02512 μM	SANGER
TE-10		Growth Inhibition Assay		IC50=0.04046 μM	SANGER
TE-11		Growth Inhibition Assay		IC50=0.02809 μM	SANGER
TE-12		Growth Inhibition Assay		IC50=0.05613 μM	SANGER
TE-15		Growth Inhibition Assay		IC50=0.02738 μM	SANGER
TE-441-T		Growth Inhibition Assay		IC50=0.5012 μM	SANGER
TE-5		Growth Inhibition Assay		IC50=0.05063 μM	SANGER
TE-6		Growth Inhibition Assay		IC50=0.05722 μM	SANGER
TE-8		Growth Inhibition Assay		IC50=0.00941 μM	SANGER
TE-9		Growth Inhibition Assay		IC50=0.02261 μM	SANGER
TFK-1		Growth Inhibition Assay	72 h	IC50=13.45 nM	21965739
TGBC1TKB		Growth Inhibition Assay		IC50=0.05405 μM	SANGER
TGBC1-TKB		Growth Inhibition Assay	144 h	IC50=6.72 nM	21965739
TGBC24TKB		Growth Inhibition Assay		IC50=0.15659 μM	SANGER
TGW		Growth Inhibition Assay		IC50=2.35027 μM	SANGER
THP-1		Growth Inhibition Assay		IC50=29.7201 μM	SANGER
TK10		Growth Inhibition Assay		IC50=0.11728 μM	SANGER
TUR		Growth Inhibition Assay		IC50=41.6399 μM	SANGER
U-266		Growth Inhibition Assay		IC50=0.07497 μM	SANGER
U-698-M		Growth Inhibition Assay		IC50=8.29226 μM	SANGER
U-87-MG		Growth Inhibition Assay		IC50=25.1966 μM	SANGER
U937	1/10/100 nM	Growth Inhibition Assay	72 h	inhibits the cell proliferation in both time- and dose-dependent manne	19458358
UACC-257		Growth Inhibition Assay		IC50=0.19947 μM	SANGER
VA-ES-BJ		Growth Inhibition Assay		IC50=0.07475 μM	SANGER
WER-Rb-1	1-50 nM	Apoptosis Assay	12/24 h	induced apoptosis which can be enhanced by HT	24366665
Wittier		Growth Inhibition Assay	72 h	IC50=3.26 nM	21965739
Y79	1-50 nM	Apoptosis Assay	12/24 h	induced apoptosis which can be enhanced by HT	24366665

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BET	BRD4, Kd:37 nM
PLK2	PLK2, IC50:3.5 nM
PLK3	PLK3, IC50:9.0 nM
PLK1	PLK1, IC50:0.83 nM

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