产品说明书

SRX3177

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Chemical Structure| 2241237-51-2 同义名 : -
CAS号 : 2241237-51-2
货号 : A1951779
分子式 : C31H32N6O4S
纯度 : 99%+
分子量 : 584.689
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(42.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SRX3177 serves as a multifaceted inhibitor targeting CDK4/6, PI3K, and BRD4, demonstrating IC50s of 33 nM for BRD4 BD1, 89 nM for BRD4 BD2, 79 nM for PI3Kα, 83 nM for PI3Kδ, 3.18 μM for PI3Kγ, less than 2.5 nM for CDK4, and 3.3 nM for CDK6. It exhibits extensive cytotoxic effects on cancerous cells while sparing normal epithelial cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.71mL

0.34mL

0.17mL

8.55mL

1.71mL

0.86mL

17.10mL

3.42mL

1.71mL
参考文献

[1]Burgoyne AM, et al. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49.