3-Methyladenine | 3-MA;NSC 66389;3-Methyladenine, NSC 66389 | 3-甲基腺嘌呤 | Autophagy | PI3K

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3-甲基腺嘌呤 /3-Methyladenine {[allProObj[0].p_purity_real_show]}

货号：A145872 同义名： 3-甲基腺嘌呤 / 3-MA;NSC 66389

3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM.

3-Methyladenine 化学结构
CAS号：5142-23-4

3-Methyladenine 3D分子结构
CAS号：5142-23-4

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3-Methyladenine 纯度/质量文件产品仅供科研

货号：A145872 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

PI3K 亚型比较
自噬亚型比较

产品名称	C2β ↓ ↑	p110α ↓ ↑	p110β ↓ ↑	p110γ ↓ ↑	p110δ ↓ ↑	PI3K ↓ ↑	Vps34 ↓ ↑	其他靶点	纯度
A66	+ C2β, IC50: 462 nM	++ p110α, IC50: 32 nM							99%+
Taselisib	+ C2β, IC50: 292 nM	++++ PI3Kα, Ki: 0.29 nM	+++ PI3Kβ, Ki: 9.1 nM	++++ PI3Kγ, Ki: 0.97 nM	++++ PI3Kδ, Ki: 0.12 nM		+ hVps34, IC50: 374 nM		99%+
Gedatolisib		++++ PI3Kα, IC50: 0.4 nM		+++ PI3Kγ, IC50: 5.4 nM				mTOR	98%
HS-173		++++ PI3Kα , IC50: 0.8 nM							99%+
Serabelisib		+++ PI3Kα, IC50: 21 nM							99%+
GNE-477		++++ PI3Kα, IC50: 4 nM						mTOR	98%
YM-201636		+ p110α, IC50: 3.3 μM						PIKfyve	98%
AS-252424		+ PI3Kα, IC50: 935 nM		++ PI3Kγ, IC50: 33 nM					99%
Alpelisib		+++ PI3Kα, IC50: 5 nM							99%+
AS-604850		+ PI3Kα, IC50: 4.5 μM		+ PI3Kγ, IC50: 0.25 μM					98+%
SF2523		++ PI3Kα, IC50: 34 nM		++ PI3Kγ, IC50: 158 nM				DNA-PK,mTOR	99%+
Inavolisib		++++ PI3K alpha, IC50: 0.038 nM							99%+
Bimiralisib		++++ PI3Kα, Kd: 1.5 nM	+++ PI3Kβ, Kd: 11 nM	++ PI3Kγ, Kd: 25 nM	++ PI3Kδ, Kd: 25 nM			mTOR	99%+
GSK1059615		++++ PI3Kα, IC50: 0.4 nM	++++ PI3Kβ, IC50: 0.6 nM	+++ PI3Kγ, IC50: 5 nM	++++ PI3Kδ, IC50: 2 nM			mTOR	98%
GSK2636771			✔						98%
Fimepinostat		+++ PI3Kα, IC50: 19 nM	++ PI3Kβ, IC50: 54 nM		++ PI3Kδ, IC50: 39 nM				99%+
VS-5584		++++ PI3Kα, IC50: 2.6 nM	+++ PI3Kβ, IC50: 21 nM	++++ PI3Kγ, IC50: 3.0 nM	++++ PI3Kδ, IC50: 2.7 nM			mTOR	99%
Dactolisib		++++ p110α1, IC50: 4 nM	++ p110β, IC50: 75 nM	+++ p110γ, IC50: 5 nM	+++ p110δ, IC50: 7 nM				98+%
PI-103		++++ p110α, IC50: 2 nM	++++ p110β, IC50: 3 nM	+++ p110γ, IC50: 15 nM	++++ p110δ, IC50: 3 nM			DNA-PK,mTOR	99%+
PI-3065			+ p110β, IC50: 1078 nM		+++ p110δ, IC50: 15 nM				99%+
Voxtalisib		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			DNA-PK,mTOR	99%+
AZD-8835		+++ PI3Kα, IC50: 6.2 nM	+ PI3Kβ, IC50: 431 nM	++ PI3Kγ, IC50: 90 nM	+++ PI3Kδ, IC50: 5.7 nM				98%
Pilaralisib analogue		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 36 nM	+++ PI3Kγ, IC50: 23 nM	++ PI3Kδ, IC50: 36 nM				99%+
ZSTK474		+++ PI3Kα, IC50: 16 nM	++ PI3Kβ, IC50: 44 nM	++ PI3Kγ, IC50: 49 nM	+++ PI3Kδ, IC50: 4.6 nM	++ PI3K, IC50: 37 nM			98%
AS-605240		++ PI3Kα, IC50: 60 nM	+ PI3Kβ, IC50: 270 nM	+++ PI3Kγ, IC50: 8 nM	+ PI3Kδ, IC50: 300 nM				98%
TGX-221			+++ p110β, IC50: 5 nM		++ p110δ, IC50: 0.1 μM				99%+
PF-04691502		++++ PI3Kα, Ki: 1.8 nM	++++ PI3Kβ, Ki: 2.1 nM	++++ PI3Kγ, Ki: 1.9 nM	++++ PI3Kδ, Ki: 1.6 nM			mTOR	98+%
GDC-0084		++++ PI3Kα, Ki app: 2 nM	++ PI3Kβ, Ki app: 46 nM	+++ PI3Kγ, Ki app: 10 nM	++++ PI3Kδ, Ki app: 3 nM			mTOR	99%+
Buparlisib		++ p110α, IC50: 52 nM	+ p110β, IC50: 166 nM	+ p110γ, IC50: 262 nM	++ p110δ, IC50: 116 nM		+ Vps34, IC50: 2.4 μM	mTOR	98%
LY294002		+ p110α, IC50: 0.5 μM	+ p110β, IC50: 0.97 μM		+ p110δ, IC50: 0.57 μM			DNA-PK	99%+
AZD 6482		+ PI3Kα, IC50: 870 nM	+++ PI3Kβ, IC50: 10 nM		++ PI3Kδ, IC50: 80 nM			DNA-PK	99%+
Pictilisib		++++ p110α, IC50: 3 nM	++ p110β, IC50: 33 nM	++ p110γ, IC50: 75 nM	++++ p110δ, IC50: 3 nM			mTOR	99%+
PKI-402		++++ PI3Kα, IC50: 2 nM	+++ PI3Kβ, IC50: 7 nM	+++ PI3Kγ, IC50: 16 nM	+++ PI3Kδ, IC50: 14 nM			mTOR	99+%
Copanlisib		++++ PI3Kα, IC50: 0.5 nM	++++ PI3Kβ, IC50: 3.7 nM	+++ PI3Kγ, IC50: 6.4 nM	++++ PI3Kδ, IC50: 0.7 nM				99%+
Omipalisib		++++ p110α, Ki: 0.019 nM	++++ p110β, Ki: 0.13 nM	++++ p110γ, Ki: 0.06 nM	++++ p110δ, Ki: 0.024 nM				99%+
Izorlisib		+++ PI3Kα, IC50: 14 nM	++ PI3Kβ, IC50: 0.12 μM	++ PI3Kγ, IC50: 36 nM	+ PI3Kδ, IC50: 0.50 μM				99%+
AZD8186		++ PI3Kα, IC50: 35 nM	++++ PI3Kβ, IC50: 4 nM		+++ PI3Kδ, IC50: 12 nM				98+%
KU-0060648		++++ PI3Kα, IC50: 4 nM	++++ PI3Kβ, IC50: 0.5 nM	+ PI3Kγ, IC50: 0.59 μM	++++ PI3Kδ, IC50: 0.1 nM			DNA-PK	99%
Apitolisib		+++ p110α, IC50: 5 nM	++ p110β, IC50: 27 nM	+++ p110γ, IC50: 14 nM	+++ p110δ, IC50: 7 nM			mTOR	98%+
CZC24832			+ PI3Kβ, IC50: 1.1 μM	++ PI3Kγ, IC50: 27 nM					98+%
BGT226 maleate		++++ PI3Kα, IC50: 4 nM	++ PI3Kβ, IC50: 63 nM	++ PI3Kγ, IC50: 38 nM				mTOR	99%+
TG 100713		++ PI3Kα, IC50: 165 nM	+ PI3Kβ, IC50: 215 nM	++ PI3Kγ, IC50: 50 nM	+++ PI3Kδ, IC50: 24 nM				98%+
PI3K-IN-1		++ PI3Kα, IC50: 39 nM	++ PI3Kβ, IC50: 113 nM	+++ PI3Kγ, IC50: 9 nM	++ PI3Kδ, IC50: 43 nM			DNA-PK,mTOR	98+%
TG100-115		+ PI3Kα, IC50: 1.3 μM	+ PI3Kβ, IC50: 1.2 μM	++ PI3Kγ, IC50: 83 nM	+ PI3Kδ, IC50: 235 nM				98%
PIK-90		+++ PI3Kα, IC50: 11 nM	+ PI3Kβ, IC50: 350 nM	+++ PI3Kγ, IC50: 18 nM	++ PI3Kδ, IC50: 58 nM				99%+
PIK-294			+ p110β, IC50: 490 nM	++ p110γ, IC50: 160 nM	+++ p110δ, IC50: 10 nM				99%+
Duvelisib			++++ PI3Kβ, Ki: 1564 pM	++ PI3Kγ, Ki: 243 pM	++++ PI3Kδ, Ki: 23 pM				99%+
GDC-0326		++++ PI3Kα, Ki: 0.2 nM	++ PI3Kβ, Ki: 26.6 nM	+++ PI3Kγ, Ki: 10.2 nM	++++ PI3Kδ, Ki: 4 nM				98%
Quercetin Dihydrate			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM				95%
Quercetin			+ PI3Kβ, IC50: 5.4 μM	+ PI3Kγ, IC50: 2.4 μM	+ PI3Kδ, IC50: 3.0 μM			Sirtuin,Src,PKC	97%
Leniolisib		+ PI3Kα, IC50: 0.244 μM	+ PI3Kβ, IC50: 0.424 μM	+ PI3Kγ, IC50: 2.23 μM	+++ PI3Kδ, IC50: 0.011 μM			DNA-PK	99%+
PIK-108			✔						98%
Eganelisib				+++ PI3Kγ, IC50: 16 nM					99%+
CAY10505				✔					98%
IPI-3063					++++ p110δ, IC50: 2.5 nM				99%
Nemiralisib					++++ PI3Kδ, pKi: 9.9				99%+
PF-4989216		++++ p110α, IC50: 2 nM		++ p110γ, IC50: 65 nM	++++ p110δ, IC50: 1 nM				99%+
PIK-75 HCl		+++ p110α, IC50: 5.8 nM		++ p110γ, IC50: 76 nM	+ p110δ, IC50: 0.51 μM			DNA-PK	99%+
Tenalisib				++ PI3Kγ, IC50: 33.2 nM	++ PI3Kδ, IC50: 24.5 nM				95+%
Acalisib					+++ p110δ, IC50: 14 nM				99%+
Umbralisib					+++ PI3Kδ, IC50: 22.2 nM				99%+
AMG319				+ PI3Kγ, IC50: 850 nM	+++ PI3Kδ, IC50: 18 nM				99%
IC-87114				+ PI3Kγ, IC50: 29 μM	+ PI3Kδ, IC50: 0.5 μM				99%+
Idelalisib				++ p110γ, IC50: 89 nM	++++ p110δ, IC50: 2.5 nM				98%
PIK-293				+ p110γ, IC50: 10 μM	+ p110δ, IC50: 0.24 μM				99%+
Vps34-PIK-III					+ PI3Kδ, IC50: 1.2μM		+++ Vps34, IC50: 0.018μM		99%+
GSK2292767					✔				99+%
Seletalisib				+ PI3Kγ, IC50: 282 nM	+++ PI3Kδ, IC50: 12 nM				99%+
P110δ-IN-1					++++ P110δ, IC50: 0.6 nM				98%
PI3Kδ-IN-5					++++ PI3Kδ, IC50: 0.9 nM				98%
SRX3207		+ PI3K alpha, IC50: 244 nM		+ PI3K gamma, IC50: 9790 nM	+ PI3K delta, IC50: 388 nM			Syk	98%
Parsaclisib HCl					++++ PI3Kδ, IC50: 1 nM				98%
IHMT-PI3Kδ-372					+++ PI3Kδ, IC50: 14 nM				98%
Trigonelline						✔		Akt	99%+
Wortmannin						++++ PI3K, IC50: 3 nM		DNA-PK,MLCK	99%+
Samotolisib						✔		DNA-PK	99%+
GNE-317						✔			99%+
Oroxin B						✔		PTEN,Akt	99%+
NU 7026						+ PI3K, IC50: 13 μM		DNA-PK	98+%
Deguelin						✔		Akt	99%+
Ailanthone						✔		ATM/ATR,CDK,Akt	98%
Resibufogenin						✔		ROS	98%
KU-57788						+ PI3K, IC50: 5 μM		DNA-PK,mTOR	99%+
Cinobufagine						✔		Akt	98%
α-Linolenic acid						✔			97% GC
MTX-211						✔		EGFR	98%
PI3K/mTOR Inhibitor-2						++++ PI3K, IC50: 3.4 nM		mTOR	99%+
SPP-86						✔			99%+
(E)-Akt inhibitor-IV						✔			98%
Vps34-IN-1							++ Vps34, IC50: 25 nM		98%
SAR405							++++ Vps34, IC50: 1.2 nM		98+%
3-Methyladenine				+ PI3Kγ, IC50: 60 μM			+ Vps34, IC50: 25 μM	Autophagy	98%
Vps34-IN-4							+++ VPS34, IC50: 15 nM		98%+
Autophinib							+++ Vps34, IC50: 19 nM	Autophagy	97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK1, IC50: 108 nM ULK2, IC50: 711 nM		97%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 hydrochloride	++++ ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		97%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

3-Methyladenine 生物活性

靶点	p110γ PI3Kγ, IC50:60 μM Vps34 Vps34, IC50:25 μM
描述	Vps34 is one kind of PI3K isoform, which plays an essential role in endosomal trafficking of proteins to the vacuole/lysosome, autophagy and phagocytosis. 3-Methyladenine (3-MA) shows inhibition of Vps34 in vitro, with an IC50 of 25 μM as compared with 60 μM for PI3Kγ. 3-Methyladenine is typically employed at a concentration of 10 mM in cellular studies^[1]. It is usually served as the inhibitor for both autophagy^[1] and type 1 mitophagy through suppression of class III PI3K activity ^[2]. However, now it was found that 3-Methyladenine play a dual role in modulation of autophagy. Prolonged treatment with 3-Methyladenine (5mM) up to 9 h can induce LC3 I to II conversion in wild type MEFs, L929 and 293T cells cultured in full-medium, whereas it is still effective in suppressing LC3 II conversation in cells induced by starvation. And this observation is consistent with result of punctuate formation of GFP-LC3 study. These results demonstrate that prolonged treatment with 3-Methyladenine under nutrient-rich conditions can enhance autophagic flux. This may due to its different temporal patterns of inhibition on Class I and III PI3K^[3].
作用机制	May due to the specific hydrophobic ring to Vps34 encircles the 3-methyl group of 3-MA.^[1]

3-Methyladenine 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
1321N1	5mM	Cytotoxicity Assay	24h	protects cell against PCN-induced toxicity	23525265
95D	3mM	Growth Inhibition Assay	2h	reduces growth inhibitory effect of BDMC	25716561
95D	5mM	Apoptosis Assay	2h	inhibits BDMC-induced apoptotic cell death	25716561
A2780	5mM	Apoptosis Assay	24h	converts FTY720 with CDDP into an additive effect towards killing ovarian cancer cells	23592281

3-Methyladenine 动物研究

Animal Administration	Rats: 15 mg/kg^[4] Mice: 35 mg/kg^[5]
Dose	Mice: 35 mg/kg^[5] Rats: 15 mg/kg^[4]
Administration	i.v., i.p.

3-Methyladenine 参考文献

[1]Miller S, Oleksy A, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010;6(6):805-7.

[2]Petiot A, Ogier-Denis E, et al. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem. 2000;275(2):992-8.

[3]Wu YT, Tan HL, et al. Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem. 2010;285(14):10850-61.

[4]Liu H, Lei H, et al. Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats. Acta Pharmacol Sin. 2017;38(7):990-997.

[5]Slavin SA, Leonard A, et al. Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018;314(3):L388-L396.

3-Methyladenine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

6.70mL

1.34mL

0.67mL

33.52mL

6.70mL

3.35mL

67.05mL

13.41mL

6.70mL

3-Methyladenine 技术信息

CAS号	5142-23-4
分子式	C₆H₇N₅
分子量	149.153

别名	3-甲基腺嘌呤 ;3-MA;NSC 66389;3-Methyladenine, NSC 66389
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 7 mg/mL(46.93 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 5 mg/mL(33.52 mM)，配合低频超声助溶

动物实验配方

IP 2% DMSO+water 0.4 mg/mL clear

PO 0.5% CMC-Na 66 mg/mL suspension

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

1321N1	5mM	Cytotoxicity Assay	24h	protects cell against PCN-induced toxicity	23525265
95D	3mM	Growth Inhibition Assay	2h	reduces growth inhibitory effect of BDMC	25716561
95D	5mM	Apoptosis Assay	2h	inhibits BDMC-induced apoptotic cell death	25716561
A2780	5mM	Apoptosis Assay	24h	converts FTY720 with CDDP into an additive effect towards killing ovarian cancer cells	23592281
A2780cp	1mM	Growth Inhibition Assay	1h	increases cisplatin-induced cell death	25322694
A2780cp	2.5mM	Apoptosis Assay	1h	enhances cisplatin-induced cell death	24817946
A2780cp	2.5mM	Apoptosis Assay	1h	enhances cisplatin-induced cell death	24817946
A549	3mM	Growth Inhibition Assay	2h	reduces growth inhibitory effect of BDMC	25716561
A549	5mM	Apoptosis Assay	2h	inhibits BDMC-induced apoptotic cell death	25716561
A549	5mM	Function Assay	2h	suppresses SPC induced accumulation of LC3-II	25285628
A549	5mM	Apoptosis Assay	48h	decreases the percentage of cell death and expression levels of caspase-3, Beclin-1 and LC3-II	24706303
A549	10mM	Apoptosis Assay	48h	accelerates the reduction of cell viability induced by PTX	24626722
A549	10mM	Function Assay	4h	inhibits autophagy induced by irradiation	24142735
A549	0.1mM	Function Assay	24h	suppresses SU11274-induced cell death	22466960
ACHN-5968	5mM	Apoptosis Assay	3h	enhances paclitaxel-mediated apoptosis	24305604
BGC-823	5mM	Function Assay	2h	inhibits the rate of autophagic cells	22322152
ECSCs	10mM	Apoptosis Assay	4h	decreases rapamycin-treated apoptosis	24319109
GTL-16	5mM	Apoptosis Assay	24h	reduces cell viability as compared to cells treated with MET inhibitors	23313490
H1299	10mM	Function Assay	4h	increases cisplatin-induced cell death	24173208
H157	5mM	Function Assay	2h	suppresses SPC induced accumulation of LC3-II	25285628
H460	10mM	Function Assay	4h	increases cisplatin-induced cell death	24173208
HBx	10mM	Apoptosis Assay	48h	increases cell death	22020078
HCT116	5mM	Apoptosis Assay	24h	enhances the apoptosis induced by apigenin	24626522
HCT116	5mM	Apoptosis Assay	24h	enhances apigenin-induced cell death	24626522
HeLa	10mM	Function Assay	2h	suppresses LC3 II expressison	23864738
Hela	5mM	Function Assay	24h	inhibits starvation-induced autophagy	23395679
HeLa	10mM	Apoptosis Assay	2h	decreases cell viability co-treatment with PEI	23000135
HeLa	5mM	Apoptosis Assay	24h	induces caspase-dependent cell death	22545128
HeLa	2mM	Cytotoxicity Assay	24h	inhibites the cytotoxicity of silibinin to HeLa cells.	21875385
Hep3B	2mM	Apoptosis Assay	12h	inhibits AZD8055-induced cell death	24297300
Hep3B	5mM	Apoptosis Assay	24h	attenuates TNF-α protection against serum starvation-mediated apoptosis	24066693
HepG2	5mM	Function Assay	4h	increases HL release	24713587
HepG2	10mM	Function Assay	24h	inhibits siTIGAR- and HBSS-induced autophagy	23817040
HepG2	3mM	Apoptosis Assay	5h	reduces cell apoptosis induced by QDs	22836595
HepG2	5mM	Function Assay	4h	increases cellular levels of HL	24713587
HepG2	2mM	Apoptosis Assay	1h	enhances radiation-induced cell death	21453691
HepG2 E47	2.5mM	Function Assay	48h	increases the toxicity of AA, BSO, and CCl4	24273738
HGC-27	10mM	Function Assay	1h	inhibits the cell viability loss by RAD001 or MK-2206	24416349
HO8910	10mM	Apoptosis Assay	12h	enhances B19-induced apoptosi	23983610
HONE-1	5mM	Function Assay	1h	represses 6r-mediated ROS production	23892358
HT-29	1mM	Apoptosis Assay	48h	enhances bortezomib-induced cell viability loss	24842158
HT-29	1mM	Function Assay	48/96h	inhibits AMPK induces autophagic cell death	23508272
Huh7	2mM	Apoptosis Assay	12h	inhibits AZD8055-induced cell death	24297300
HUVECs	3mM	Function Assay	24h	blocks the protective effect of resveratrol by inhibiting autophagy	23358928
HUVECs	10mM	Function Assay	0.5h	decreases the AGE-BSAinduced autophagy leve	21468592
Jurkat	10mM	Function Assay	1h	decreases the expression of LC3-II and the formation of autophagosomes	21864037
K562	10mM	Function Assay	1h	decreases the expression of LC3-II and the formation of autophagosomes	21864037
LoVo	5mM	Apoptosis Assay	48h	enhances DCA-induced apoptosis.	24201812
Marc-145	5mM	Function Assay	12/24/36h	reduces the PRRSV titers and the protein expression	22119900
MCF7	5mM	Function Assay	24h	increases CuO induced cell death	23962629
MCF-7	10mM	Function Assay	24h	inhibits the autophagy induced by chemotherapy drugs	24315578
MCF-7	5mM	Function Assay	24h	inhibits starvation-induced autophagy	23395679
MCF-7	2mM	Function Assay	24h	inhibits autophagy induced by TM	24970676
MCF-7	2mM	Function Assay	48h	promotes TM-induced cell death	24970676
MCF-7	0.1mM	Apoptosis Assay	6h	enhances sirtinol-induced apoptosis	22751989
MCF-7	10mM	Function Assay	48h	blocks autophagy induced by bortezomib	21931937
MDA-MB 231	5mM	Apoptosis Assay	0.5h	modulates Tocomin® induced apoptosis	24830781
MDA-MB231	5mM	Function Assay	1h	increases resveratrol-mediated caspase activation and cell death	23088850
MDA-MB-231	2mM	Function Assay	24h	inhibits autophagy induced by TM	24970676
MDA-MB-231	2mM	Function Assay	48h	promotes TM-induced cell death	24970676
MDR	10mM	Apoptosis Assay	6h	strengthens the power of anticancer drugs	25019701
MG-63	0.5/1mM	Function Assay	48h	induces salinomycin-induced cell viability loss	24358342
MG-63	0.5/1mM	Apoptosis Assay	32h	enhances salinomycin-induced cell apoptosis	24358342
MG-63	10mM	Apoptosis Assay	12h	enhances DP-induced apoptosis	24358301
Microglia	5mM	Apoptosis Assay	24h	decreases hypoxia-induced cell death	24818601
Microglia	5mM	Apoptosis Assay	24h	decreases hypoxia-induced cell death	24818601
Nara-H	5mM	Growth Inhibition Assay	48h	enhances temsirolimusmediated suppression of Nara-H cell proliferation	21805033
NBL-W-S	1mM	Growth Inhibition Assay	6h	enhances GANT-61 toxicity	25323222
NBL-W-S	1mM	Apoptosis Assay	6h	increases cell apoptosis induced by GANT-61	25323222
NTUB1	5mM	Apoptosis Assay	1.5h	potentiates celecoxib-induced apoptosis	24349176
OR6	10mM	Function Assay	72h	suppresses HCV replication and formation of autophagosomes	23395875
OV2008	5mM	Apoptosis Assay	24h	converts FTY720 with CDDP into an additive effect towards killing ovarian cancer cells	23592281
PaCa44	2.5mM	Apoptosis Assay	1h	reduces genipin-mediated apoptosis	23124112
PANC-1	1mM	Apoptosis Assay	48h	enhances bortezomib-induced cell viability loss	24842158
PC12	10mM	Function Assay	24h	inhibits chymotrypsin-like proteasomal activity.	23603979
PC12/TetOn	0.1/1mM	Function Assay	18h	leads to α-syn(WT) accumulation, toxicity, and oligomer formation	21906659
PC-3	2mM	Apoptosis Assay	2h	increases ORI-induced cell death	22745580
pDCs	10mM	Function Assay	0.5h	reduces the induction of IFN-α by ssRNA40	22396599
RKO	2mM	Function Assay	1h	enhances cell death by geldanamycin	24291777
RMPI8226	5mM	Function Assay	1h	suppresses the level of autophagy under nutrient depletion	21915620
Saos-2	10mM	Apoptosis Assay	24h	intensifies the growth inhibition of the U2OS cells induced by Dox	24639013
Saos-2	1mM	Apoptosis Assay	96h	increases cell death induced by PCX	23563171
SGC-7901	2mM	Apoptosis Assay	1h	increases CA-4 induced apoptosis	24321340
SH-SY5Y	1mM	Function Assay	24h	inhibits the autophagy induced by TOCP	23743148
SH-SY5Y	5mM	Apoptosis Assay	1h	abolishes celastrol neuroprotective effect	23619395
SH-SY5Y	5mM	Cytotoxicity Assay	24h	increases PCN toxicity	23525265
SK-HEP-1	10mM	Apoptosis Assay	1h	protects against autophagy and induces apoptosis in bufalin-treated cells	22858649
SMMC-7721	2mM	Apoptosis Assay	1h	increases CA-4 induced apoptosis	24321340
SMMC-7721	5mM	Apoptosis Assay	24h	attenuates TNF-α protection against serum starvation-mediated apoptosis	24066693
T24	5mM	Apoptosis Assay	1.5h	potentiates celecoxib-induced apoptosis	24349176
T24	10mM	Function Assay	1h	reduces the cleavage of LC3 after baicalin treatment	23354080
T-47D	10mM	Function Assay	2h	inhibits autophagy process and increases rapamycin induced apoptosis	23300026
U251	5mM	Apoptosis Assay	24h	increases S1-induced cell death	22579788
U251MG	3mM	Function Assay	1h	suppresses LC3-II protein expression	23338618
U2OS	10mM	Apoptosis Assay	24h	intensifies the growth inhibition of the U2OS cells induced by Dox	24639013
U2OS	0.5/1mM	Function Assay	48h	induces salinomycin-induced cell viability loss	24358342
U2OS	10mM	Growth Inhibition Assay	24h	intensifies the growth inhibition induced by Dox	24639013
U937	2mM	Function Assay	12h	decreases the autophagy ratio	22155150
UOK257	5mM	Apoptosis Assay	3h	enhances paclitaxel-mediated apoptosis	24305604
WiDr	10mM	Function Assay	1h	inhibits PCBL-induced LC3 II expression	24190489

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