货号:A843943
同义名:
α-亚麻酸
/ Octadecatrienoic acid (all cis-9,12,15);alpha-Linolenic acid
α-Linolenic acid, an essential fatty acid found in leafy green vegetables, acts as part of a low saturated fat diet, helps prevent cardiovascular disease. It can decreases blood pressure, serum cholesterol levels, and platelet aggregation.
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描述 | α-Linolenic acid (ALA), isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer. α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g). α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[3]. ALA but not LA supplementation alleviated systolic blood pressure elevation and improved ACh-induced, endothelium-dependent vasodilation in both spontaneously hypertensive rats (SHRs) and AngII-induced hypertensive mice. In primary cultured endothelial cells, ALA treatment directly inhibited SIRT3 reduction, SOD2 hyperacetylation, mitochondrial ROS overproduction and alleviated autophagic flux impairment induced by AngII plus TNFα treatment[4]. Consumption of vegetable oils rich in alpha-linolenic acid could confer important cardiovascular protection[5]. α-linolenic acid prevents ER stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes might become a target to develop new antiapoptotic compounds in nonalcoholic fatty liver disease[6]. ALA also as a potential nutraceutical to protect the brain from stroke, characterized by its pleiotropic effects in neuroprotection, vasodilation of brain arteries, and neuroplasticity[7]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00892684 | Allergies | Not Applicable | Unknown | September 2011 | Sweden ... 展开 >> University Hospital Linkoeping, Sweden, 58185 收起 << |
NCT01943409 | Obstruction C... 展开 >>ancer Ileus Malnutrition Surgery 收起 << | Phase 4 | Recruiting | June 2019 | Canada, Ontario ... 展开 >> University Health Network Recruiting Toronto, Ontario, Canada, M5G 2C4 Contact: Sultan Alenezi, MScAHN +1-416-340-4413 sultan.alenezi@uhnresearch.ca Contact: Monica L Ponta, MD +1-416-340-4413 monica.ponta@uhnresearch.ca Principal Investigator: Johane P Allard, MD 收起 << |
NCT02590848 | Vitamin/Nutritional Deficiency... 展开 >> Neurobehavioral Manifestations 收起 << | Not Applicable | Active, not recruiting | January 2019 | Spain ... 展开 >> Fundació Centre de Recerca en Epidemiologia Ambiental Barcelona, Spain, 08003 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.59mL 0.72mL 0.36mL |
17.96mL 3.59mL 1.80mL |
35.92mL 7.18mL 3.59mL |
CAS号 | 463-40-1 |
分子式 | C18H30O2 |
分子量 | 278.43 |
别名 | α-亚麻酸 ;Octadecatrienoic acid (all cis-9,12,15);alpha-Linolenic acid;DPN63401;C18:3 (all cis-9,12,15) Fatty acid |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(377.12 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 无水乙醇: 100 mg/mL(359.16 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇 |
动物实验配方 |