货号:A183964
同义名:
LY293646;DNA-PK Inhibitor II
NU7026 is a potent and selective inhibitor of DNA-PK with IC50 of 0.23 μM.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | DNA-PK ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PI-103 |
++
DNA-PK, IC50: 23 nM |
99%+ | |||||||||||||||||
CC-115 |
+++
DNA-PK, IC50: 0.013 μM |
mTOR | 99%+ | ||||||||||||||||
Samotolisib | ✔ | 99%+ | |||||||||||||||||
NU 7026 |
+
DNA-PK, IC50: 0.23 μM |
PI3K | 99%+ | ||||||||||||||||
PIK-75 HCl |
++++
DNA-PK, IC50: 2 nM |
99%+ | |||||||||||||||||
PP121 |
+
DNA-PK, IC50: 60 nM |
VEGFR,PDGFR | 99%+ | ||||||||||||||||
KU-0060648 |
++++
DNA-PK, IC50: 5 nM |
99% | |||||||||||||||||
KU-57788 |
+++
DNA-PK, IC50: 14 nM |
99%+ | |||||||||||||||||
LTURM34 |
++
DNA-PK, IC50: 0.034 μM |
99%+ | |||||||||||||||||
SF2523 |
+++
DNA-PK, IC50: 9 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM[1]. NU7026 enhances the cytotoxic effects of ionizing radiation (IR) in cells proficient in DNA-PK, evidenced by a potentiation factor at 90% cell kill (PF90) of 1.51±0.04[1]. In vitro, at a 10 μM concentration, which itself is not toxic to cells, NU7026 4-hour exposure combined with 3 Gy of radiation to significantly increase radiosensitivity in CH1 human ovarian cancer cells[3]. |
体内研究 | After intravenous delivery at 5 mg/kg to mice, NU7026 shows rapid plasma clearance at a rate of 0.108 L/h, primarily due to extensive metabolism. Its bioavailability after interperitoneal (i.p.) and oral (p.o.) administration at 20 mg/kg is observed to be 20% and 15%, respectively[3]. |
体外研究 | NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM[1]. NU7026 enhances the cytotoxic effects of ionizing radiation (IR) in cells proficient in DNA-PK, evidenced by a potentiation factor at 90% cell kill (PF90) of 1.51±0.04[1]. In vitro, at a 10 μM concentration, which itself is not toxic to cells, NU7026 4-hour exposure combined with 3 Gy of radiation to significantly increase radiosensitivity in CH1 human ovarian cancer cells[3]. |
细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
HeLa cells | Function assay | Inhibition of DNA dependent protein kinase isolated from HeLa cells, IC50=0.23 μM | 15658870 | ||
HeLa cells | Function assay | Inhibition of mTOR protein isolated from HeLa cells, IC50=6.4 μM | 15658870 |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.55mL 0.71mL 0.36mL |
17.77mL 3.55mL 1.78mL |
35.55mL 7.11mL 3.55mL |
CAS号 | 154447-35-5 |
分子式 | C17H15NO3 |
分子量 | 281.306 |
别名 | LY293646;DNA-PK Inhibitor II |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 2 mg/mL(7.11 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
1% DMSO+30% polyethylene glycol+1% Tween 80+water 30 mg/mL suspension |