NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM[1]. NU7026 enhances the cytotoxic effects of ionizing radiation (IR) in cells proficient in DNA-PK, evidenced by a potentiation factor at 90% cell kill (PF90) of 1.51±0.04[1]. In vitro, at a 10 μM concentration, which itself is not toxic to cells, NU7026 4-hour exposure combined with 3 Gy of radiation to significantly increase radiosensitivity in CH1 human ovarian cancer cells[3].
体内研究
After intravenous delivery at 5 mg/kg to mice, NU7026 shows rapid plasma clearance at a rate of 0.108 L/h, primarily due to extensive metabolism. Its bioavailability after interperitoneal (i.p.) and oral (p.o.) administration at 20 mg/kg is observed to be 20% and 15%, respectively[3].
体外研究
NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM[1].
NU7026 enhances the cytotoxic effects of ionizing radiation (IR) in cells proficient in DNA-PK, evidenced by a potentiation factor at 90% cell kill (PF90) of 1.51±0.04[1].
In vitro, at a 10 μM concentration, which itself is not toxic to cells, NU7026 4-hour exposure combined with 3 Gy of radiation to significantly increase radiosensitivity in CH1 human ovarian cancer cells[3].
NU 7026 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
HeLa cells
Function assay
Inhibition of DNA dependent protein kinase isolated from HeLa cells, IC50=0.23 μM
15658870
HeLa cells
Function assay
Inhibition of mTOR protein isolated from HeLa cells, IC50=6.4 μM
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