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Glycyrrhizic acid
甘草酸 /Glycyrrhizic acid
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货号：A499217
同义名：
Glycyrrhizin;NSC 167409
Glycyrrhizic ac id是一种三萜皂苷，作为直接的 HMGB 1 拮抗剂，具有抗肿瘤 和抗糖尿病 活性。
Glycyrrhizic acid 化学结构
Glycyrrhizic acid 3D分子结构
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Glycyrrhizic acid 纯度/质量文件 产品仅供科研
货号：A499217
标准纯度：
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产品说明书
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Glycyrrhizic acid 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132H-IDH1, IC50: 70 nM
R132C-IDH1, IC50: 0.16 μM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
98%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (rat), IC50: 3 nM
SCD1 (mouse), IC50: 1 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Glycyrrhizic acid 生物活性
靶点
描述
Monoamine oxidases (MAO) are a group of enzymes that inactivate monoamine neurotransmitters and catalyze the oxidation of monoamines ingested in food. Glycyrrhizic acid (GA) is a MAO inhibitor with an IC50 value of 0.16 μM[3] [4] + -dependent 11-HSD2 activity in kidney was significantly decreased to 44% and 34%, respectively, as compared to control group. A significant reduction in renal 11-HSD2 protein and mRNA expressions was also observed in rats dosed with 120 mg/kg GA when compared to vehicle-treated group[5]
Glycyrrhizic acid 动物研究
Dose
Rat: 15 mg/kg[3] [2]
Administration
p.o.
Glycyrrhizic acid 参考文献
[1] Gong G, Xiang L, et al. Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats. PLoS One. 2014 Mar 4;9(3):e89450.
[2] Tanahashi T, Mune T, et al. Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase expression in vivo. J Steroid Biochem Mol Biol. 2002 Apr;80(4-5):441-7.
[3] Hatano T, Fukuda T, Miyase T, Noro T, Okuda T. Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase. Chem Pharm Bull (Tokyo). 1991 May;39(5):1238-43. doi: 10.1248/cpb.39.1238. PMID: 1913999.
[4] Sitia G, Iannacone M, Müller S, Bianchi ME, Guidotti LG. Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. J Leukoc Biol. 2007 Jan;81(1):100-7. doi: 10.1189/jlb.0306173. Epub 2006 Aug 25. PMID: 16935945.
[5] Tanahashi T, Mune T, Morita H, Tanahashi H, Isomura Y, Suwa T, Daido H, Gomez-Sanchez CE, Yasuda K. Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase expression in vivo. J Steroid Biochem Mol Biol. 2002 Apr;80(4-5):441-7. doi: 10.1016/s0960-0760(02)00033-x. PMID: 11983491.
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Glycyrrhizic acid 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.22mL
0.24mL
0.12mL
6.08mL
1.22mL
0.61mL
12.15mL
2.43mL
1.22mL
Glycyrrhizic acid 技术信息
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