Moclobemide | Ro111163 | MAOI Antidepressant | AmBeed-信号通路专用抑制剂

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吗氯贝胺 /Moclobemide {[allProObj[0].p_purity_real_show]}

货号：A566201 同义名： Ro111163

Moclobemide is a reversible MAO-A inhibitor.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Moclobemide 化学结构
CAS号：71320-77-9

Moclobemide 3D分子结构
CAS号：71320-77-9

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Moclobemide 纯度/质量文件产品仅供科研

货号：A566201 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

MAO 亚型比较

产品名称	MAO ↓ ↑	MAO-A ↓ ↑	MAO-B ↓ ↑	纯度
Sennoside A	++ MAO, IC50: 17 μM			98%+
Glycyrrhizic acid	++++ MAO, IC50: 0.16 μM			80% HPLC
Rasagiline		++++ MAO-A, IC50: 412 nM	++++ MAO-B, IC50: 4.43 nM	99+%
Isatin	++ MAO, IC50: 15 μM	+ MAO-A, IC50: 58 μM	++ MAO-B, IC50: 14 μM	98%
Paeonol		+ MAO-A, IC50: 54.6 μM	+ MAO-B, IC50: 42.5 μM	98%
Tranylcypromine hydrochloride		+++ MAO-A, IC50: 11.5 μM	+++ MAO-B, IC50: 7 μM	97%
Moclobemide		+++ MAO-A (5-HT), IC50: 6.1 μM		99%+
Pargyline HCl		++ MAO-A, Ki: 13 μM	+++ MAO-B, Ki: 0.5 μM	99%+
Safinamide			++++ MAO-B, IC50: 98 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Moclobemide 生物活性

靶点

MAO-A

MAO-A (5-HT), IC50:6.1 μM

描述

Moclobemide is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A^[3]. Moclobemide is a reversible inhibitor of monoamine-oxidase-A (RIMA) and has been extensively evaluated in the treatment of a wide spectrum of depressive disorders. The effective therapeutic dose range for moclobemide in most acute phase trials was 300 to 600 mg, divided in 2 to 3 doses. Cases of refractory depression might improve with a combination of moclobemide with other antidepressants, such as clomipramine or a SSRI (selective serotonin reuptake inhibitors)^[4]. In humans, moclobemide is rapidly absorbed after a single oral administration and maximum concentration in plasma is reached within an hour. In the case of moclobemide, increase in the level of serotonin is the most pronounced. Moclobemide administration also leads to increased monoamine receptor stimulation, reversal of reserpine induced behavioral effects, selective depression of REM sleep, down regulation of beta-adrenoceptors and increases in plasma prolactin and growth hormone levels. It reduces scopolamine-induced performance decrement and alcohol induced performance deficit which suggest a neuroprotective role^[5]. Long-term treatment with moclobemide causes gynecomastia in rats, which is reversible^[6]. Morever, moclobemide overdose in combination with a serotonergic agent (even in normal therapeutic doses) can cause severe serotonin toxicity^[7].

Moclobemide 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02269540	Major Depressive Disorder	Early Phase 1	Recruiting	July 2018	Canada, Ontario ... 展开 >> Research Imaging Centre, Centre for Addiction and Mental Health Recruiting Toronto, Ontario, Canada, M5T 1R8 Principal Investigator: Jeffrey H Meyer, MD, PhD 收起 <<
NCT01544309	Hypercholesterolemia With Conc... 展开 >>omitant Type 2 Diabetes 收起 <<	Not Applicable	Completed	-	-
NCT00068224	-		Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<

Moclobemide 参考文献

[1]Verleye M, Steinschneider R, et al. Moclobemide attenuates anoxia and glutamate-induced neuronal damage in vitro independently of interaction with glutamate receptor subtypes. Brain Res. 2007 Mar 23;1138:30-8.

[2]Da Prada M, Kettler R, et al. Neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. J Pharmacol Exp Ther. 1989 Jan;248(1):400-14.

[3]Can NÖ, Osmaniye D, Levent S, Sağlık BN, İnci B, Ilgın S, Özkay Y, Kaplancıklı ZA. Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity. Molecules. 2017 Aug 20;22(8):1381

[4]Bonnet U. Moclobemide: therapeutic use and clinical studies. CNS Drug Rev. 2003 Spring;9(1):97-140

[5]Nair NP, Ahmed SK, Kin NM. Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide. J Psychiatry Neurosci. 1993 Nov;18(5):214-25

[6]Ma XC, Wang Y, Liu JH, Tu ZH. Moclobemide-induced gynecomastia in rats. Acta Pharmacol Sin. 2000 Oct;21(10):893-6

[7]Isbister GK, Hackett LP, Dawson AH, Whyte IM, Smith AJ. Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity. Br J Clin Pharmacol. 2003 Oct;56(4):441-50

Moclobemide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.72mL

0.74mL

0.37mL

18.61mL

3.72mL

1.86mL

37.21mL

7.44mL

3.72mL

Moclobemide 技术信息

CAS号	71320-77-9
分子式	C₁₃H₁₇ClN₂O₂
分子量	268.739

别名	Ro111163
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(390.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02269540	Major Depressive Disorder	Early Phase 1	Recruiting	July 2018	Canada, Ontario ... 展开 >> Research Imaging Centre, Centre for Addiction and Mental Health Recruiting Toronto, Ontario, Canada, M5T 1R8 Principal Investigator: Jeffrey H Meyer, MD, PhD 收起 <<
NCT01544309	Hypercholesterolemia With Conc... 展开 >>omitant Type 2 Diabetes 收起 <<	Not Applicable	Completed	-	-
NCT00068224	-		Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT01544309	-		Completed	-	-
NCT01962753	Elderly Major... 展开 >> Depression 收起 <<	Not Applicable	Unknown	May 2018	France ... 展开 >> University Hospital of Besançon- Jean Minjoz Recruiting Besançon, France, 25030 Contact: Pierre VANDEL pierre.vandel@univ-fcomte.fr University Hospital of Caen Recruiting Caen, France, 14000 Contact: Sonia DOLLFUS dollfus-s@chu-caen.fr University Hospital of Lille Recruiting Lille, France, 59000 Contact: Jean ROCHE Jean.ROCHE@CHRU-LILLE.FR University Hospital of Nice Recruiting Nice, France, 06000 Contact: Philippe ROBERT robert.p@chu-nice.fr Sainte-Anne Hospital Recruiting Paris, France, 75014 Contact: Thierry GALLARDA T.GALLARDA@ch-sainte-anne.fr Le Rouvray Hospital Recruiting Sotteville lès Rouen, France, 76300 Contact: Marie DESBORDES marie.desbordes@ch-lerouvray.fr University Hospital of Strasbourg - HUS Recruiting Strasbourg, France, 67098 Contact: Frédéric BLANC frederic.blanc@chru-strasbourg.fr University Hospital of Toulouse - Purpan Recruiting Toulouse, France, 31059 Contact: Christophe ARBUS arbus.c@chu-toulouse.fr University Hospital of Tours Recruiting Tours, France, 37000 Contact: Vincent CAMUS vincent.camus@univ-tours.fr 收起 <<
NCT00704860	Major Depression	Phase 4	Completed	-	Canada, Ontario ... 展开 >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 收起 <<
NCT02222220	Clozapine-induced Hypersalivat... 展开 >>ion 收起 <<	Phase 3	Completed	-	Israel ... 展开 >> Be'er Sheva Mental Health Center, Be'er Sheva, Israel, 8417000 收起 <<
NCT03010761	Addiction	Phase 2	Terminated(all participants fi... 展开 >>nished the trial) 收起 <<	-	-
NCT00534573	Clozapine-induced Hypersalivat... 展开 >>ion 收起 <<	Phase 3	Completed	-	Israel ... 展开 >> Be'er Sheva Mental Health Center, Tirat HaKarmel Mental Health Center Be'er Sheva, Haifa, Israel 收起 <<
NCT01926626	Nicotine Dependence	Phase 2	Completed	-	United States, North Carolina ... 展开 >> Duke Center for Smoking Cessation Charlotte, North Carolina, United States, 28210 Duke Center forSmoking Cessation Durham, North Carolina, United States, 27705 Duke Center for Smoking Cessation Winston-Salem, North Carolina, United States, 27103 收起 <<
NCT01926626	-		Completed	-	-
NCT02374567	Dementia Depr... 展开 >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders 收起 <<	Phase 3	Terminated	-	Germany ... 展开 >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany 收起 <<

吗氯贝胺 /Moclobemide {[allProObj[0].p_purity_real_show]}

Moclobemide 纯度/质量文件产品仅供科研

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Moclobemide 生物活性

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Moclobemide 参考文献

Moclobemide 实验方案

Moclobemide 技术信息

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吗氯贝胺 /Moclobemide {[allProObj[0].p_purity_real_show]}

Moclobemide 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Moclobemide 质控信息

Moclobemide 生物活性

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Moclobemide 参考文献

Moclobemide 实验方案

Moclobemide 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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