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Isovaleramide
3-甲基丁酰胺 /Isovaleramide
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货号：A959606
同义名：
异戊酰胺
/ 3-Methylbutanamide
Isovaleramide, a liver alcohol dehydrogenases inhibitor, is an anticonvulsant molecule isolated from Valeriana pavonii.
Isovaleramide 化学结构
Isovaleramide 3D分子结构
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Isovaleramide 纯度/质量文件 产品仅供科研
货号：A959606
标准纯度：
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Isovaleramide 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132C-IDH1, IC50: 0.16 μM
R132H-IDH1, IC50: 70 nM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
98%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (mouse), IC50: 1 nM
SCD1 (rat), IC50: 3 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Isovaleramide 生物活性
靶点
描述
Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant. Isovaleramide at 100 mg/kg, p.o, evidenced a 90% index protection against the maximal electroshock seizure in mice (MES), comparable to the reference agent: sodium phenytoin (20 mg/kg, p.o, 100%). In the in vitro assay, isovaleramide (300 µM) exhibited a 42% of inhibition of the binding of ³H-FNZ to its sites[3] [4]
Isovaleramide 参考文献
[1] Giraldo SE, Rincon J, et al. [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii] .Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish.
[2] Bialer M, Johannessen SI, et al. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.
[3] Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF. Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]. Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish
[4] Chadha VK, Leidal KG, Plapp BV. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26(6):916-22
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Isovaleramide 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
9.89mL
1.98mL
0.99mL
49.43mL
9.89mL
4.94mL
98.87mL
19.77mL
9.89mL
Isovaleramide 技术信息
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