Trilostane | 曲洛斯坦 | Win 24540 | 3-β-Hydroxysteroid Dehydrogenase Inhibitor

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曲洛司坦 /Trilostane {[allProObj[0].p_purity_real_show]}

货号：A378777 同义名： 曲洛斯坦 / Win 24540;Desopan

Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase for Cushing's syndrome.

Trilostane 化学结构
CAS号：13647-35-3

Trilostane 3D分子结构
CAS号：13647-35-3

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Trilostane 纯度/质量文件产品仅供科研

货号：A378777 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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脱氢酶亚型比较

产品名称	Dehydrogenase ↓ ↑	纯度
Trilostane	✔	99+%
AGI-6780	+++ IDH2 R140Q mutant, IC50: 23 nM	99%+
Gimeracil	✔	98%
AGI-5198	++ R132H-IDH1, IC50: 70 nM R132C-IDH1, IC50: 0.16 μM	99%+
SW033291	++++ 15-PGDH, IC50: 1.5 nM 15-PGDH, Ki: 0.1 nM	99%+
Mycophenolic acid	✔	99+%
Fomepizole	✔	98%
Leflunomide	✔	98%
3-Nitropropanoic acid	✔	99%+
Isovaleramide	✔	98%
Mycophenolate Mofetil	+++ Inosine monophosphate dehydrogenase I, IC50: 39 nM Inosine monophosphate dehydrogenase II, IC50: 27 nM	98%
MK-8245	++++ SCD1 (rat), IC50: 3 nM SCD1 (mouse), IC50: 1 nM	99%+
Vidofludimus	++ Human DHODH, IC50: 134 nM	99%+
Emodin	✔	98%
Ivosidenib	✔	98%
NCT-501	++ ALDH1A1, IC50: 40 nM	98%
Gossypol	✔	99%+
Devimistat	✔	98%
Disulfiram	✔	98%+
Enasidenib	++++ IDH2, IC50: 12 nM	98%
PluriSIn 1	✔	99%+
ML390	+ DHODH, IC50: 0.56 μM	99%+
Teriflunomide	✔	99%+
Daidzin	+++ ALDH-Ⅰ, Ki: 20 nM	98+%
18β-Glycyrrhetinic acid	✔	99%
RRx-001	✔	95%
NCT-503	+ PHGDH, IC50: 2.5 μM	99%+
Vorasidenib	✔	99%+
Ammonium Glycyrrhizinate(x:1)	✔	98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Trilostane 生物活性

靶点

Dehydrogenase

描述

Trilostane is a recognized treatment for canine pituitary-dependent hyperadrenocorticism (PDH); The median survival time for animals treated with trilostane was 353 days (95% confidence interval [CI] 95-528 days)^[3]. During trilostane therapy, urinary catecholamines and their metabolites did not decrease significantly. However, dogs with low post-ACTH cortisol concentrations during trilostane therapy had less increased epinephrine, norepinephrine and normetanephrine, creatinine ratios compared to healthy dogs^[4]. In a substantial number of dogs treated with trilostane, the two prepill cortisol concentrations differed. Part of this difference might be ascribable to stressful events during test performance^[5].

Trilostane 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01615211	Medical Abortion, Complete or ... 展开 >>Unspecified, Without Complication 收起 <<	Phase 2	Terminated(No access to study ... 展开 >>drug Trilostan. Company closed down) 收起 <<	-	Sweden ... 展开 >> Karolinska University Hospital Stockholm, Sweden, 17177 收起 <<
NCT00181597	Prostate Cancer ... 展开 >> Prostate Adenocarcinoma 收起 <<	Phase 2	Completed	-	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<

Trilostane 参考文献

[1]Feldman EC, Kass PH. Trilostane dose versus body weight in the treatment of naturally occurring pituitary-dependent hyperadrenocorticism in dogs. J Vet Intern Med. 2012 Jul-Aug;26(4):1078-80.

[2]Helm JR, McLauchlan G, et al. A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. J Vet Intern Med. 2011 Mar-Apr;25(2):251-60.

[3]Helm JR, McLauchlan G, Boden LA, Frowde PE, Collings AJ, Tebb AJ, Elwood CM, Herrtage ME, Parkin TD, Ramsey IK. A comparison of factors that influence survival in dogs with adrenal-dependent hyperadrenocorticism treated with mitotane or trilostane. J Vet Intern Med. 2011 Mar-Apr;25(2):251-60

[4]Sieber-Ruckstuhl N, Salesov E, Quante S, Riond B, Rentsch K, Hofmann-Lehmann R, Reusch C, Boretti F. Effects of Trilostane on urinary Catecholamines and their metabolites in dogs with Hypercortisolism. BMC Vet Res. 2017 Sep 4;13(1):279

[5]Boretti F, Musella C, Burkhardt W, Kuemmerle-Fraune C, Riond B, Reusch C, Sieber-Ruckstuhl N. Comparison of two prepill cortisol concentrations in dogs with hypercortisolism treated with trilostane. BMC Vet Res. 2018 Dec 27;14(1):417

Trilostane 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.18mL

3.04mL

1.52mL

30.36mL

6.07mL

3.04mL

Trilostane 技术信息

CAS号	13647-35-3
分子式	C₂₀H₂₇NO₃
分子量	329.433

别名	曲洛斯坦 ;Win 24540;Desopan;Modrenal.;Modrastane. Desopan;D-01180;DB01108;Vetoryl;Modrefen
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 55 mg/mL(166.95 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 2 mg/mL clear

PO 0.5% CMC-Na 42 mg/mL suspension

曲洛司坦 /Trilostane {[allProObj[0].p_purity_real_show]}

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Trilostane 质控信息

Trilostane 生物活性

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Trilostane 参考文献

Trilostane 实验方案

Trilostane 技术信息

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曲洛司坦 /Trilostane {[allProObj[0].p_purity_real_show]}

Trilostane 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Trilostane 质控信息

Trilostane 生物活性

Trilostane 临床研究

Trilostane 参考文献

Trilostane 实验方案

Trilostane 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Trilostane 纯度/质量文件产品仅供科研