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/ Gossypol

棉酚 /Gossypol {[allProObj[0].p_purity_real_show]}

货号：A428070 同义名： 棉子酚 / BL 193;NSC 56817

Gossypol has been known to exert a potential for anti-cancer, anti-inflammatory and other important therapeutic activities, gossypol binds and antagonizes anti-apoptotic effect of Bcl-2 family proteins

Gossypol 化学结构 CAS号：303-45-7
Gossypol 化学结构
CAS号：303-45-7
Gossypol 3D分子结构
CAS号：303-45-7
Gossypol 化学结构 CAS号：303-45-7
Gossypol 3D分子结构 CAS号：303-45-7
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Gossypol 纯度/质量文件 产品仅供科研

货号：A428070 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Bax ↓ Bcl-2 ↓ Bcl-B ↓ Bcl-w ↓ Bcl-xL ↓ Bfl-1 ↓ Mcl-1 ↓ 其他靶点 纯度
BTSA1 ✔ 99%+
HA14-1 +

Bcl-2, IC50: 9 μM

 		98%
Venetoclax ++++

Bcl-2, Ki: <0.01 nM

 		99%
Navitoclax 99%+
Obatoclax Mesylate +++

Bcl-2, Ki: 0.22 μM

 		98%
ABT-737 +++

Bcl-2, EC50: 30.3 nM

 		+

Bcl-B, EC50: 1.82 μM

 		+++

Bcl-w, EC50: 197.8 nM

 		+++

Bcl-xL, EC50: 78.7 nM

 		99%+
Gambogic Acid +

Bfl-1, IC50: 1.06 μM

Bcl-2, IC50: 1.21 μM

 		++

Bcl-B, IC50: 0.66 μM

 		++++

Bcl-w, IC50: 0.02 μM

 		+

Bcl-xL, IC50: 1.47 μM

 		+

Bfl-1, IC50: 1.06 μM

 		++

Mcl-1, IC50: 0.79 μM

 		Caspase 99% HPLC
BH3I-1 +

BH3-Bcl-xL interaction, Ki: 2.4 μM

 		98%
A-1331852 ++++

Bcl-xL, Ki: <0.01 nM

 		99%+
A-1210477 ++++

MCL-1, IC50: 26.2 nM

 		99%+
Maritoclax ✔ 97%
TW-37 +++

Bcl-2, Ki: 0.29 μM

 		+

Bcl-xL, Ki: 1.11 μM

 		+++

Mcl-1, Ki: 0.26 μM

 		98%
UMI-77 ++

Mcl-1, Ki: 490 nM

 		97%
(R)-(-)-Gossypol acetic acid ++

Bcl-2, Ki: 0.32 μM

 		++

Bcl-xL, Ki: 0.48 μM

 		+++

Mcl-1, Ki: 0.18 μM

 		98%
Sabutoclax ++

Bfl-1, IC50: 0.62 μM

Bcl-2, IC50: 0.32 μM

 		++

Bcl-xL, IC50: 0.31 μM

 		++

Bfl-1, IC50: 0.62 μM

 		+++

Mcl-1, IC50: 0.20 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Gossypol 生物活性

靶点

  • Dehydrogenase
描述 Gossypol, derived from cottonseeds and roots, is a natural compound investigated for its anticancer properties. The racemic form, (±)-Gossypol, has been well tolerated in various clinical trials. It binds to Bcl-xL protein with a Ki ranging from 0.5 to 0.6 μM and to Bcl-2 protein with a Ki of 0.2-0.3 mM. The racemic Gossypol consists of two enantiomers: (-)-Gossypol and (+)-Gossypol. In 6-day MTT assays against UM-SCC-6 and UM-SCC-14A cell lines, (-)-Gossypol demonstrates significantly higher growth inhibition compared to (±)-Gossypol, whereas (+)-Gossypol shows lower inhibition (P<0.001). A moderate inhibitory effect is observed with (±)-Gossypol, predominantly at a higher dose (10 μM, P<0.0001).
体外研究

Gossypol, derived from cottonseeds and roots, is a natural compound investigated for its anticancer properties. The racemic form, (±)-Gossypol, has been well tolerated in various clinical trials. It binds to Bcl-xL protein with a Ki ranging from 0.5 to 0.6 μM and to Bcl-2 protein with a Ki of 0.2-0.3 mM. The racemic Gossypol consists of two enantiomers: (-)-Gossypol and (+)-Gossypol. In 6-day MTT assays against UM-SCC-6 and UM-SCC-14A cell lines, (-)-Gossypol demonstrates significantly higher growth inhibition compared to (±)-Gossypol, whereas (+)-Gossypol shows lower inhibition (P<0.001). A moderate inhibitory effect is observed with (±)-Gossypol, predominantly at a higher dose (10 μM, P<0.0001).

Gossypol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02938520 HIV Infections Phase 2 Phase 3 Active, not recruiting July 7, 2022 -
NCT01265199 Acute Myelogenous Leukemia (AM... 展开 >>L) 收起 << Phase 1 Terminated(Study was terminate... 展开 >>d before a MTD was determined for administrative reasons) 收起 << - United States, Illinois ... 展开 >> Univerity of Chicago Chicago, Illinois, United States United States, Michigan University of Michigan Health System Ann Arbor, Michigan, United States United States, Missouri Washington University at St. Louis Siteman Cancer Center St. Louis, Missouri, United States United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States Temple University at Jeanes Hospital Philadelphia, Pennsylvania, United States 收起 <<
NCT00244374 - Completed - -

Gossypol 参考文献

[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.

Gossypol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.64mL

1.93mL

0.96mL

19.28mL

3.86mL

1.93mL

Gossypol 技术信息

CAS号303-45-7
分子式C30H30O8
分子量 518.554
别名 棉子酚 ;BL 193;NSC 56817;Pogosin;NSC 624336
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 35 mg/mL(67.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Gossypol | 303-45-7 | BL 193 | BL193 | BL-193 | Bcl-2 Family Antagonist | Apoptosis | Bcl-2 Family | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Gossypol 纯度/质量文件 | Gossypol 亚型比较 | Gossypol 生物活性 | Gossypol 临床数据 | Gossypol 参考文献 | Gossypol 实验方案 | Gossypol 技术信息

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