丹皮酚 /Paeonol
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货号：A173012
同义名：
2-羟基-4-甲氧基苯乙酮
/ 2'-Hydroxy-4'-methoxyacetophenone;Peonol
Paeonol is a naturally occuring MAO inhibitor with IC50 values of 54.6 μM and 42.5 μM for MAO-A and MAO-B, respectively.
Paeonol 化学结构
Paeonol 3D分子结构
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Paeonol 纯度/质量文件 产品仅供科研
货号：A173012
标准纯度：
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产品说明书
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Paeonol 质控信息
Paeonol 生物活性
靶点
MAO-B
MAO-B, IC50:42.5 μM
MAO-A
MAO-A, IC50:54.6 μM
描述
Monoamine oxidase (MAO) is an important enzyme in the metabolism of a wide range of endogenous monoamine neurotrasmitters such as noradrenaline, dopamine, and serotonin (5-HT), and also catalyzes as well the removal of exogenous amines. Paeonol, originated from the traditional Chinese medicine, is a naturally occuring MAO inhibitor with IC50 values of 54.6 μM and 42.5 μM for MAO-A and MAO-B, respectively[7] [8] [9]
Paeonol 动物研究
Dose
Mice: 20 mg/kg[3] [4] [5] [2] [6]
Administration
i.p., p.o., i.v.
Pharmacokinetics
Animal
Rats[5]
Dose
5 mg/kg
Administration
i.v.
Vd
394 ± 22.8 L/kg
A
11.17 ± 0.93 μg/ml
B
1.72 ± 0.18 μg/ml
AUC
114.8 ± 10.3 μg·min/ml
T1/2β
30.6 ± 1.70 min
CL
49.3 ± 1.85 ml/min/kg
α
0.26 ± 0.03 1/min
β
0.023 ± 0.002 1/min
Paeonol 参考文献
[1] Kong LD, Cheng CH, Tan RX. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5.
[2] Chou TC. Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia. Br J Pharmacol. 2003 Jul;139(6):1146-52.
[3] Lee H, Lee G, et al. Paeonol, a major compound of moutan cortex, attenuates Cisplatin-induced nephrotoxicity in mice. Evid Based Complement Alternat Med. 2013;2013:310989.
[4] Antidepressant-like Effect of Paeonol
[5] Tsai TH, Chou CJ, et al. Pharmacokinetics of paeonol after intravenous administration in rats. J Pharm Sci. 1994 Sep;83(9):1307-9.
[6] Ma L, Chuang CC, et al. Paeonol Protects Rat Heart by Improving Regional Blood Perfusion during No-Reflow. Front Physiol. 2016 Jul 21;7:298.
[7] Kong LD, Cheng CH, Tan RX. Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones. J Ethnopharmacol. 2004 Apr;91(2-3):351-5. doi: 10.1016/j.jep.2004.01.013. PMID: 15120460.
[8] Gao L, Wang Z, Lu D, Huang J, Liu J, Hong L. Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death Dis. 2019 Aug 13;10(8):609. doi: 10.1038/s41419-019-1849-x. PMID: 31406198; PMCID: PMC6690917.
[9] Wang Q, Xu X, Kang Z, Zhang Z, Li Y. Paeonol prevents IL-1β-induced inflammatory response and degradation of type II collagen in human primary chondrocytes. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2139-2145. doi: 10.1080/21691401.2019.1613418. PMID: 31146598.
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Paeonol 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
6.02mL
1.20mL
0.60mL
30.09mL
6.02mL
3.01mL
60.18mL
12.04mL
6.02mL
Paeonol 技术信息
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