ML390
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货号：A589360
ML390 is a human DHODH inhibitor that induces differentiation in acute myeloid leukemia.
ML390 化学结构
ML390 3D分子结构
规格
价格
会员价
库存
数量
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ML390 纯度/质量文件 产品仅供科研
货号：A589360
标准纯度：
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产品说明书
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ML390 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132H-IDH1, IC50: 70 nM
R132C-IDH1, IC50: 0.16 μM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
98%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (rat), IC50: 3 nM
SCD1 (mouse), IC50: 1 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
ML390 生物活性
靶点
Dehydrogenase
DHODH, IC50:0.56 μM
描述
Dihydroorotate dehydrogenase (DHODH) catalyzes the oxidation of dihydroorotate to orotate in de novo pyrimidine synthesis, e.g., uridine 5′-monophosphate. ML390 is a small-molecule probe active in overcoming differentiation arrest in a model of AML (acute myeloid leukemia). Its effect is due to inhibition of DHODH-catalyzed pyrimidine synthesis[3] [4]
作用机制
The (R )-amino tetralin group of ML390 is located within the innermost part of the cavity and makes the closest contact[3]
ML390 参考文献
[1] Lewis TA, Sykes DB, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.
[2] Sykes DB, Haynes MK, et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. 2013 Dec 15 [updated 2015 Feb 11] .
[3] Lewis TA, Sykes DB, Law JM, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett . 2016;7(12):1112‐1117
[4] Sykes DB, Haynes MK, Waller A, et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. In: Probe Reports from the NIH Molecular Libraries Program . Bethesda (MD): National Center for Biotechnology Information (US); 2010
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ML390 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.46mL
0.49mL
0.25mL
12.30mL
2.46mL
1.23mL
24.61mL
4.92mL
2.46mL
ML390 技术信息
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