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脱氢酶
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Mycophenolic acid
霉酚酸 /Mycophenolic acid
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货号：A399663
同义名：
Mycophenolate;MPA
Mycophenolic ac id 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂，EC50 为 0.24 μM。Mycophenolic ac id 对多种 RNA 病毒具有抗病毒 作用，包括流感 (influenza)。Mycophenolic ac id 是一种免疫抑制剂。具有抗血管生成和抗肿瘤 作用。
Mycophenolic acid 化学结构
Mycophenolic acid 3D分子结构
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Mycophenolic acid 纯度/质量文件 产品仅供科研
货号：A399663
标准纯度：
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产品说明书
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Mycophenolic acid 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132C-IDH1, IC50: 0.16 μM
R132H-IDH1, IC50: 70 nM
99%+
SW033291
++++
15-PGDH, Ki: 0.1 nM
15-PGDH, IC50: 1.5 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
98%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (rat), IC50: 3 nM
SCD1 (mouse), IC50: 1 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Mycophenolic acid 生物活性
靶点
描述
Mycophenolic acid (MPA) is an immunosuppressant requiring therapeutic drug monitoring. It is commonly prescribed in adult kidney transplant recipients for preventing graft rejection[3] [4] [5] [6]
Mycophenolic acid 参考文献
[1] Sintchak MD, Fleming MA, et al. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell. 1996 Jun 14;85(6):921-30.
[2] Eugui EM, Almquist SJ, et al. Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depletion. Scand J Immunol. 1991 Feb;33(2):161-73.
[3] Kiang TKL, Ensom MHH. Exposure-Toxicity Relationships of Mycophenolic Acid in Adult Kidney Transplant Patients. Clin Pharmacokinet. 2019 Dec;58(12):1533-1552
[4] Nazemian F, Mohammadpur AH, Abtahi B, Naghibi M. Pharmacokinetics of mycophenolic acid during the early period after renal transplant. Exp Clin Transplant. 2007 Dec;5(2):658-63
[5] Batovska DI, Kim DH, Mitsuhashi S, Cho YS, Kwon HJ, Ubukata M. Hydroxamic acid derivatives of mycophenolic acid inhibit histone deacetylase at the cellular level. Biosci Biotechnol Biochem. 2008 Oct;72(10):2623-31
[6] Arns W. Noninfectious gastrointestinal (GI) complications of mycophenolic acid therapy: a consequence of local GI toxicity? Transplant Proc. 2007 Jan-Feb;39(1):88-93
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Mycophenolic acid 实验方案
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摩尔计算器
总药量计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.12mL
0.62mL
0.31mL
15.61mL
3.12mL
1.56mL
31.22mL
6.24mL
3.12mL
Mycophenolic acid 技术信息
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