18β-甘草次酸 /18β-Glycyrrhetinic acid
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货号：A480562
同义名：
18β-甘草次酸;甘草次酸
/ Arthrodont;Enoxolone
Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice.
18β-Glycyrrhetinic acid 化学结构
18β-Glycyrrhetinic acid 3D分子结构
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18β-Glycyrrhetinic acid 纯度/质量文件 产品仅供科研
货号：A480562
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18β-Glycyrrhetinic acid 质控信息
18β-Glycyrrhetinic acid 生物活性
靶点
描述
Enoxolone is Gap junction inhibitor and a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti-microbial activities.In vitro ， this Enoxolone derivative did not cause cell death, but significantly enhanced the proliferation of dermal fibroblasts and HaCaT keratinocytes. A scratch wound healing assay revealed that the Enoxolone derivative promoted the migration of fibroblasts[3] In vivo ，histological data also indicated Enoxolone has no effects on inflammatory joint destruction[4]
18β-Glycyrrhetinic acid 参考文献
[1] Zhu J, Chen M, et al. Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway. Int J Oncol. 2015 Mar;46(3):981-8.
[2] Pirzadeh S, Fakhari S, et al. Glycyrrhetinic Acid Induces Apoptosis in Leukemic HL60 Cells Through Upregulating of CD95/ CD178. Int J Mol Cell Med. 2014 Fall;3(4):272-8.
[3] Hung CF, Hsiao CY, Hsieh WH, Li HJ, Tsai YJ, Lin CN, Chang HH, Wu NL. 18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. PLoS One. 2017 Aug 16;12(8):e0182981. doi: 10.1371/journal.pone.0182981. PMID: 28813533; PMCID: PMC5558956.
[4] Puchner A, Hayer S, Niederreiter B, Hladik A, Blueml S, Bonelli M, Scheinecker C, Smolen J, Redlich K. Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis. Wien Klin Wochenschr. 2012 Mar;124(5-6):170-6. doi: 10.1007/s00508-011-0103-z. Epub 2012 Jan 3. PMID: 22210441.
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18β-Glycyrrhetinic acid 实验方案
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摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.12mL
0.42mL
0.21mL
10.62mL
2.12mL
1.06mL
21.25mL
4.25mL
2.12mL
18β-Glycyrrhetinic acid 技术信息
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