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叶酸 /Folic acid {[allProObj[0].p_purity_real_show]}

货号:A133193 同义名: Vitamin B9;Vitamin M

Folic acid (Vitamin B9) 是一种来自维生素 B 群的口服活性必需营养素,具有抗抑郁作用,能降低新生儿神经管缺陷的风险,并用于研究因叶酸缺乏引起的巨幼红细胞性贫血和大红细胞性贫血。

Folic acid 化学结构 CAS号:59-30-3
Folic acid 化学结构
CAS号:59-30-3
Folic acid 3D分子结构
CAS号:59-30-3
Folic acid 化学结构 CAS号:59-30-3
Folic acid 3D分子结构 CAS号:59-30-3
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Folic acid 纯度/质量文件 产品仅供科研

货号:A133193 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 DNA synthesis helicase RdRp ribonucleotide reductase tRNA synthetase YB-1 其他靶点 纯度
Fexinidazole 98%
Daptomycin 98%
Blasticidin S·HCl 98%
Metronidazole 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

98%
Triglycidyl isocyanurate p53 98+%
Nedaplatin 99%+
Bendamustine 98+%
Trifluridine 98%
Robinetin 99%+
Carboplatin 99%
Cidofovir 99%
Cisplatin 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

99%+
Oxaliplatin 98%
YK-4-279 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

99%+
RK-33 98%
Brr2-IN-3 99%+
Phen-DC3 Trifluoromethanesulfonate 98%
Favipiravir 99%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

97%
Didox 98%
(E)-3-AP 99%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, Kd: 42.1 nM

Leucyl-tRNA synthetase, IC50: 46.11 nM

98%
SU056 +

YB-1, IC50: 1.73 μM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Folic acid 生物活性

描述 Folic acid is a synthetic form of the vitamin, which is only found in fortified foods, supplements and pharmaceuticals. It lacks coenzyme activity and must be reduced to the metabolically active tetrahydrofolate form within the cell[3]. With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk[4]. Nanoemulsion is a promising strategy to enhance folic acid stability[5]. Derivatives of folic acid such as biopterins and the synthesis of S-adenosyl methionine (SAM) are known either to be associated with improvement or to have a direct therapeutic effect in depressive disorder[6].

Folic acid 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00096330 Colorectal Cancer Phase 1 Completed - United States, New York ... 展开 >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 收起 <<
NCT00693589 Cardiovascular Disease ... 展开 >> Endothelial Dysfunction 收起 << Phase 2 Completed - -
NCT00372645 Healthy Not Applicable Completed - United Kingdom ... 展开 >> Institute of Food Research Norwich, Norfolk, United Kingdom, NR4 7UA University of Sheffield Sheffield, Yorkshire, United Kingdom, S10 2FN 收起 <<

Folic acid 参考文献

[1]Price RJ, Lillycrop KA, Burdge GC. Folic acid supplementation in vitro induces cell type-specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair. Nutr Res. 2015 Jun;35(6):532-44.

[2]Shin JH, Shiota K. Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring. J Nutr. 1999 Nov;129(11):2070-3.

[3]Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48

[4]van Gool JD, Hirche H, Lax H, De Schaepdrijver L. Folic acid and primary prevention of neural tube defects: A review. Reprod Toxicol. 2018 Sep;80:73-84

[5]Adi AC, Christanto C, Rachmawati H, Adlia A. Vitamin E-based Folic Acid Nanoemulsion: Formulation and Physical Evaluation for Oral Administration. Pharm Nanotechnol. 2019;7(4):304-313

[6]Paul RT, McDonnell AP, Kelly CB. Folic acid: neurochemistry, metabolism and relationship to depression. Hum Psychopharmacol. 2004 Oct;19(7):477-88

Folic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.33mL

2.27mL

1.13mL

22.66mL

4.53mL

2.27mL

Folic acid 技术信息

CAS号59-30-3
分子式C19H19N7O6
分子量 441.397
别名 Vitamin B9;Vitamin M;Vitamin Be;Vitamin Bc;Vitamin B11;NSC 3073;Folate;Pteroylglutamic acid;Folacin
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 35 mg/mL(79.29 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

1M NaOH: 100 mg/mL(226.55 mM),配合低频超声助溶

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