Folic acid

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Chemical Structure| 59-30-3 同义名 : Vitamin B9;Vitamin M;Vitamin Be;Vitamin Bc;Vitamin B11;NSC 3073;Folate;Pteroylglutamic acid;Folacin
CAS号 : 59-30-3
货号 : A133193
分子式 : C19H19N7O6
纯度 : 98%
分子量 : 441.397
MDL号 : MFCD00079305
存储条件：

Pure form Keep in dark place,Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(79.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

1M NaOH: 100 mg/mL(226.55 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Folic acid is a synthetic form of the vitamin, which is only found in fortified foods, supplements and pharmaceuticals. It lacks coenzyme activity and must be reduced to the metabolically active tetrahydrofolate form within the cell[3]. With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk[4]. Nanoemulsion is a promising strategy to enhance folic acid stability[5]. Derivatives of folic acid such as biopterins and the synthesis of S-adenosyl methionine (SAM) are known either to be associated with improvement or to have a direct therapeutic effect in depressive disorder[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00096330 Colorectal Cancer Phase 1 Completed - United States, New York ... 展开 >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 收起 <<
NCT00693589 Cardiovascular Disease ... 展开 >> Endothelial Dysfunction 收起 << Phase 2 Completed - -
NCT00372645 Healthy Not Applicable Completed - United Kingdom ... 展开 >> Institute of Food Research Norwich, Norfolk, United Kingdom, NR4 7UA University of Sheffield Sheffield, Yorkshire, United Kingdom, S10 2FN 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.33mL

2.27mL

1.13mL

22.66mL

4.53mL

2.27mL
参考文献

[1]Price RJ, Lillycrop KA, Burdge GC. Folic acid supplementation in vitro induces cell type-specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair. Nutr Res. 2015 Jun;35(6):532-44.

[2]Shin JH, Shiota K. Folic acid supplementation of pregnant mice suppresses heat-induced neural tube defects in the offspring. J Nutr. 1999 Nov;129(11):2070-3.

[3]Pietrzik K, Bailey L, Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48

[4]van Gool JD, Hirche H, Lax H, De Schaepdrijver L. Folic acid and primary prevention of neural tube defects: A review. Reprod Toxicol. 2018 Sep;80:73-84

[5]Adi AC, Christanto C, Rachmawati H, Adlia A. Vitamin E-based Folic Acid Nanoemulsion: Formulation and Physical Evaluation for Oral Administration. Pharm Nanotechnol. 2019;7(4):304-313

[6]Paul RT, McDonnell AP, Kelly CB. Folic acid: neurochemistry, metabolism and relationship to depression. Hum Psychopharmacol. 2004 Oct;19(7):477-88