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/ 组胺受体 / Pheniramine maleate

马来酸非尼拉敏 /Pheniramine maleate {[allProObj[0].p_purity_real_show]}

货号：A293531 同义名： 非尼拉敏马来酸盐 / Prophenpyridamine maleate;Tripoton maleate Ambeed 开学季，买赠积分，赢豪礼

Pheniramine maleate can acts as an antihistamine and vasoconstrictor.

Pheniramine maleate 化学结构 CAS号：132-20-7
Pheniramine maleate 化学结构
CAS号：132-20-7
Pheniramine maleate 3D分子结构
CAS号：132-20-7
Pheniramine maleate 化学结构 CAS号：132-20-7
Pheniramine maleate 3D分子结构 CAS号：132-20-7
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Pheniramine maleate 纯度/质量文件 产品仅供科研

货号：A293531 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl {[allProObj[0].p_purity_real_show]}
Cyclizine ✔ {[allProObj[0].p_purity_real_show]}
Loratadine +

B(0)AT2, IC50: 4 μM

 		{[allProObj[0].p_purity_real_show]}
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		{[allProObj[0].p_purity_real_show]}
Doxylamine succinate ✔ {[allProObj[0].p_purity_real_show]}
Ebastine ✔ {[allProObj[0].p_purity_real_show]}
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		{[allProObj[0].p_purity_real_show]}
Meclizine dihydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenhydramine HCl ✔ {[allProObj[0].p_purity_real_show]}
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		{[allProObj[0].p_purity_real_show]}
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		{[allProObj[0].p_purity_real_show]}
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		{[allProObj[0].p_purity_real_show]}
Pemirolast potassium ✔ {[allProObj[0].p_purity_real_show]}
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		{[allProObj[0].p_purity_real_show]}
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		{[allProObj[0].p_purity_real_show]}
Brompheniramine maleate ✔ {[allProObj[0].p_purity_real_show]}
Carbinoxamine maleate salt ✔ {[allProObj[0].p_purity_real_show]}
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		{[allProObj[0].p_purity_real_show]}
Ketotifen fumarate salt ✔ {[allProObj[0].p_purity_real_show]}
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR {[allProObj[0].p_purity_real_show]}
Famotidine ✔ {[allProObj[0].p_purity_real_show]}
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		{[allProObj[0].p_purity_real_show]}
Lafutidine ✔ {[allProObj[0].p_purity_real_show]}
Cimetidine ✔ {[allProObj[0].p_purity_real_show]}
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE {[allProObj[0].p_purity_real_show]}
Ranitidine ✔ {[allProObj[0].p_purity_real_show]}
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		{[allProObj[0].p_purity_real_show]}
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		{[allProObj[0].p_purity_real_show]}
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		{[allProObj[0].p_purity_real_show]}
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		{[allProObj[0].p_purity_real_show]}
Azelastine HCl ✔ {[allProObj[0].p_purity_real_show]}
Epinastine HCl ✔ {[allProObj[0].p_purity_real_show]}
Levodropropizine ✔ {[allProObj[0].p_purity_real_show]}
Cyproheptadine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Hesperetin ✔ {[allProObj[0].p_purity_real_show]}
Olopatadine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mianserin hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Buclizine 2HCl ✔ {[allProObj[0].p_purity_real_show]}
Latrepirdine 2HCl ✔ GluR {[allProObj[0].p_purity_real_show]}
Cetirizine 2HCl ✔ {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pheniramine maleate 生物活性

描述 Pheniramine Maleate is an antihistamine that also has some anti-inflammatory effects. Histological examination demonstrated that Ph (pheniramine maleate) had protective effects against I/R injury developing in the brain tissue. Ph has a protective effect against ischemia/reperfusion injury created experimentally in rat brains[3]. Pheniramine Maleate 45.5 mg is better than placebo and as effective as lidocaine to prevent fentanyl induced cough[4]. Use of Dexamethasone and Pheniramine hydrogen maleate prior to surgical skin incision helps to reduce both postoperative pain and acute physiological stress[5]. After rats were injected intrathecally with diphenhydramine and pheniramine, the dose-response curves were obtained. Diphenhydramine and pheniramine produced dose-dependent spinal blockades in motor function, proprioception, and nociception[6].

Pheniramine maleate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02477787 Acute Myelogenous Leukemia Phase 2 Recruiting December 2019 Korea, Republic of ... 展开 >> Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: Kyoo-Hyung Lee, MD    82-2-3010-3213    khlee2@amc.seoul.kr    Contact: Inpyo Choi, PhD    82-42-860-4223    ipchoi@kribb.re.kr 收起 <<
NCT02731560 Rheumatoid Arthritis Phase 4 Completed - -
NCT01380275 Sarcoma Phase 2 Unknown December 2014 Korea, Republic of ... 展开 >> National Cancer Center Recruiting Goyang-si, Gyeonggi, Korea, Republic of Contact: Soon Mi Kim, RN    82-31-920-0425    ksm@ncc.re.kr    Principal Investigator: Byung-Kiu Park, M.D., Ph.D. 收起 <<

Pheniramine maleate 参考文献

[1]Yurekli I, Gokalp O, et al. Effect of pheniramine maleate on reperfusion injury in brain tissue. Med Sci Monit Basic Res. 2013 Dec 6;19:285-90.

[2]Moharana AK, Bhattacharya SK, et al. Possible role of histamine receptors in the central regulation of immune responses. Indian J Physiol Pharmacol. 2000 Apr;44(2):153-60.

[3]Yürekli I, Gökalp O, Kiray M, Gökalp G, Ergüneş K, Salman E, Yürekli BS, Satoğlu IS, Beşir Y, Cakır H, Gürbüz A. Effect of pheniramine maleate on reperfusion injury in brain tissue. Med Sci Monit Basic Res. 2013 Dec 6;19:285-90

[4]Ozmen O, Kara D, Karaman EU, Karakoc F, Karakaya MA, Arslan Z. Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough. Pak J Med Sci. 2016 May-Jun;32(3):715-9

[5]Shrestha BB, Karmacharya M, Gharti BB, Timilsina B, Ghimire P. Effect of Dexamethasone and Pheniramine Maleate in Patients Undergoing Elective Laparoscopic Cholecystectomy. JNMA J Nepal Med Assoc. 2014 Jul-Sep;52(195):920-4

[6]Hung CH, Chu CC, Chen YC, Chen YW, Li ZY, Wang JJ. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673(1-3):20-4

Pheniramine maleate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.06mL

5.61mL

2.81mL

Pheniramine maleate 技术信息

CAS号132-20-7
分子式C20H24N2O4
分子量 356.416
别名 非尼拉敏马来酸盐 ;Prophenpyridamine maleate;Tripoton maleate
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

H2O: 35 mg/mL(98.2 mM)
动物实验配方

PO 0.5% CMC-Na 80 mg/mL suspension

Tags: Pheniramine maleate | Prophenpyridamine maleate | 非尼拉敏马来酸盐 | Histamine Receptor | AmBeed-信号通路专用抑制剂 | Pheniramine maleate 纯度/质量文件 | Pheniramine maleate 亚型比较 | Pheniramine maleate 生物活性 | Pheniramine maleate 临床数据 | Pheniramine maleate 参考文献 | Pheniramine maleate 实验方案 | Pheniramine maleate 技术信息

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