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Pheniramine maleate

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Chemical Structure| 132-20-7 同义名 : 非尼拉敏马来酸盐 ;Prophenpyridamine maleate;Tripoton maleate
CAS号 : 132-20-7
货号 : A293531
分子式 : C20H24N2O4
纯度 : 98%
分子量 : 356.416
MDL号 : MFCD00079250
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 35 mg/mL(98.2 mM)
动物实验配方：

PO 0.5% CMC-Na 80 mg/mL suspension

生物活性
描述 Pheniramine Maleate is an antihistamine that also has some anti-inflammatory effects. Histological examination demonstrated that Ph (pheniramine maleate) had protective effects against I/R injury developing in the brain tissue. Ph has a protective effect against ischemia/reperfusion injury created experimentally in rat brains[3]. Pheniramine Maleate 45.5 mg is better than placebo and as effective as lidocaine to prevent fentanyl induced cough[4]. Use of Dexamethasone and Pheniramine hydrogen maleate prior to surgical skin incision helps to reduce both postoperative pain and acute physiological stress[5]. After rats were injected intrathecally with diphenhydramine and pheniramine, the dose-response curves were obtained. Diphenhydramine and pheniramine produced dose-dependent spinal blockades in motor function, proprioception, and nociception[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02477787 Acute Myelogenous Leukemia Phase 2 Recruiting December 2019 Korea, Republic of ... 展开 >> Asan Medical Center Recruiting Seoul, Korea, Republic of Contact: Kyoo-Hyung Lee, MD    82-2-3010-3213    khlee2@amc.seoul.kr    Contact: Inpyo Choi, PhD    82-42-860-4223    ipchoi@kribb.re.kr 收起 <<
NCT02731560 Rheumatoid Arthritis Phase 4 Completed - -
NCT01380275 Sarcoma Phase 2 Unknown December 2014 Korea, Republic of ... 展开 >> National Cancer Center Recruiting Goyang-si, Gyeonggi, Korea, Republic of Contact: Soon Mi Kim, RN    82-31-920-0425    ksm@ncc.re.kr    Principal Investigator: Byung-Kiu Park, M.D., Ph.D. 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.06mL

5.61mL

2.81mL
参考文献

[1]Yurekli I, Gokalp O, et al. Effect of pheniramine maleate on reperfusion injury in brain tissue. Med Sci Monit Basic Res. 2013 Dec 6;19:285-90.

[2]Moharana AK, Bhattacharya SK, et al. Possible role of histamine receptors in the central regulation of immune responses. Indian J Physiol Pharmacol. 2000 Apr;44(2):153-60.

[3]Yürekli I, Gökalp O, Kiray M, Gökalp G, Ergüneş K, Salman E, Yürekli BS, Satoğlu IS, Beşir Y, Cakır H, Gürbüz A. Effect of pheniramine maleate on reperfusion injury in brain tissue. Med Sci Monit Basic Res. 2013 Dec 6;19:285-90

[4]Ozmen O, Kara D, Karaman EU, Karakoc F, Karakaya MA, Arslan Z. Pheniramine Maleate is more effective than Lidocaine on Fentanyl Induced Cough. Pak J Med Sci. 2016 May-Jun;32(3):715-9

[5]Shrestha BB, Karmacharya M, Gharti BB, Timilsina B, Ghimire P. Effect of Dexamethasone and Pheniramine Maleate in Patients Undergoing Elective Laparoscopic Cholecystectomy. JNMA J Nepal Med Assoc. 2014 Jul-Sep;52(195):920-4

[6]Hung CH, Chu CC, Chen YC, Chen YW, Li ZY, Wang JJ. Spinal anesthesia with diphenhydramine and pheniramine in rats. Eur J Pharmacol. 2011 Dec 30;673(1-3):20-4