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/ Histamine Diphosphate

二磷酸组胺 /Histamine Diphosphate {[allProObj[0].p_purity_real_show]}

货号：A174108 同义名： 二磷酸组胺 一水合物 / Histamine phosphate

Histamine phosphate can dilate arteries and capillaries mediated by H1- and H2-receptors.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Histamine Diphosphate 化学结构 CAS号：51-74-1
Histamine Diphosphate 化学结构
CAS号：51-74-1
Histamine Diphosphate 3D分子结构
CAS号：51-74-1
Histamine Diphosphate 化学结构 CAS号：51-74-1
Histamine Diphosphate 3D分子结构 CAS号：51-74-1
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Histamine Diphosphate 纯度/质量文件 产品仅供科研

货号：A174108 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine dihydrochloride ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 99%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		98%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		98%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 98%
Levodropropizine ✔ 97%
Cyproheptadine hydrochloride ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin hydrochloride ✔ 99+%
Buclizine 2HCl ✔ 97%
Latrepirdine 2HCl ✔ GluR 98%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Histamine Diphosphate 生物活性

描述 Histamine (phosphate) is an endogenous biogenic amine that is synthesized from the basic amino acid histidine. The intraperitoneally injection histamine increases the MCD (Mast cell density) and induces the neuronal hypertrophy and after the comparison of the organs in the gastrointestinal tract the results indicated the most effected organ as the appendices[3]. Intravenous injection of histamine phosphate could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition[4]. Histamine base in doses of 0.5 - 2.0 mg/rat induced a significant hypocalcemic response 30 min postinjection which returned to baseline by 60 min. Likewise, the administration of 1.375 mg/rat of histamine phosphate (equivalent to 0.5 mg histamine base) also resulted in a significant fall in serum calcium concentration. In the rat the administration of histamine results in a hypocalcemic response similar to that previously observed with gastrin[5]. Moreover, histamine has a cumulative bronchoconstrictor effect if inhaled at five minute intervals once appreciable bronchoconstriction has been reached[6].

Histamine Diphosphate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01569191 Hypersensitivity Phase 4 Completed - United Kingdom ... 展开 >> National Pollen and Aerobiology Unit Worcester, United Kingdom, WR2 6AJ 收起 <<
NCT01569191 - Completed - -
NCT01179724 Delayed Bleeding Not Applicable Unknown September 2010 Korea, Republic of ... 展开 >> Samsung Medical Center Recruiting Seoul, Korea, Republic of, 82 Contact: Jae J Kim, Professor    82-2-3410-3409    jjkim@skku.edu    Principal Investigator: Jae J Kim, Professor 收起 <<

Histamine Diphosphate 参考文献

[1]Larivee Y, Leon Z, et al. Evaluation of the nasal response to histamine provocation with acoustic rhinometry. J Otolaryngol. 2001 Dec;30(6):319-23.

[2]Plevin R, Boarder MR. Stimulation of formation of inositol phosphates in primary cultures of bovine adrenal chromaffin cells by angiotensin II, histamine, bradykinin, and carbachol. J Neurochem. 1988 Aug;51(2):634-41.

[3]Keles N, Yavuz Arican R, Coskun M, Elpek GO. Histamine induces the neuronal hypertrophy and increases the mast cell density in gastrointestinal tract. Exp Toxicol Pathol. 2012 Nov;64(7-8):713-6

[4]Wang Z, Wang D, Yu Y, Li Y, Sui Y, Cui H. [Experimental model of histamine-induced anaphylactoid reaction on beagle dogs]. Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(14):1842-4. Chinese

[5]Norberg HP, Schulak JA, Atlas B, Kaplan EL. Histamine-induced hypocalcemia in the rat. Metabolism. 1976 Feb;25(2):131-4

[6]Tremblay C, Lemire I, Ghezzo H, Pineau L, Martin RR, Cartier A, Malo JL. Histamine phosphate has a cumulative effect when inhaled at five minute intervals. Thorax. 1984 Dec;39(12):946-51

Histamine Diphosphate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.28mL

3.26mL

1.63mL

32.56mL

6.51mL

3.26mL

Histamine Diphosphate 技术信息

CAS号51-74-1
分子式C5H15N3O8P2
分子量 307.135
别名 二磷酸组胺 一水合物 ;Histamine phosphate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 1 mg/mL(3.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(325.59 mM)，配合低频超声助溶
动物实验配方

PO 0.5% CMC-Na 100 mg/mL clear

Tags: Histamine | 51-74-1 | Histamine diphosphate | Histamine Receptor | Induced Disease Models Products | GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Metabolic Enzyme/Protease | Immunology and Inflammatory Disease Models | Digestive System Disease Models | Histamine Receptor | Endogenous Metabolite | Gastrointestinal Inflammation and Ulcer Models | Gastrointestinal Disease Models | Gastric Ulcer Models | Duodenal Ulcer Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Histamine Diphosphate 纯度/质量文件 | Histamine Diphosphate 亚型比较 | Histamine Diphosphate 生物活性 | Histamine Diphosphate 临床数据 | Histamine Diphosphate 参考文献 | Histamine Diphosphate 实验方案 | Histamine Diphosphate 技术信息

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