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Histamine Diphosphate

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Chemical Structure| 51-74-1 同义名 : 二磷酸组胺 一水合物 ;Histamine phosphate
CAS号 : 51-74-1
货号 : A174108
分子式 : C5H15N3O8P2
纯度 : 97%
分子量 : 307.135
MDL号 : MFCD00064316
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(3.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(325.59 mM)，配合低频超声助溶
动物实验配方：

PO 0.5% CMC-Na 100 mg/mL clear

生物活性
描述 Histamine (phosphate) is an endogenous biogenic amine that is synthesized from the basic amino acid histidine. The intraperitoneally injection histamine increases the MCD (Mast cell density) and induces the neuronal hypertrophy and after the comparison of the organs in the gastrointestinal tract the results indicated the most effected organ as the appendices[3]. Intravenous injection of histamine phosphate could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition[4]. Histamine base in doses of 0.5 - 2.0 mg/rat induced a significant hypocalcemic response 30 min postinjection which returned to baseline by 60 min. Likewise, the administration of 1.375 mg/rat of histamine phosphate (equivalent to 0.5 mg histamine base) also resulted in a significant fall in serum calcium concentration. In the rat the administration of histamine results in a hypocalcemic response similar to that previously observed with gastrin[5]. Moreover, histamine has a cumulative bronchoconstrictor effect if inhaled at five minute intervals once appreciable bronchoconstriction has been reached[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01569191 Hypersensitivity Phase 4 Completed - United Kingdom ... 展开 >> National Pollen and Aerobiology Unit Worcester, United Kingdom, WR2 6AJ 收起 <<
NCT01569191 - Completed - -
NCT01179724 Delayed Bleeding Not Applicable Unknown September 2010 Korea, Republic of ... 展开 >> Samsung Medical Center Recruiting Seoul, Korea, Republic of, 82 Contact: Jae J Kim, Professor    82-2-3410-3409    jjkim@skku.edu    Principal Investigator: Jae J Kim, Professor 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.28mL

3.26mL

1.63mL

32.56mL

6.51mL

3.26mL
参考文献

[1]Larivee Y, Leon Z, et al. Evaluation of the nasal response to histamine provocation with acoustic rhinometry. J Otolaryngol. 2001 Dec;30(6):319-23.

[2]Plevin R, Boarder MR. Stimulation of formation of inositol phosphates in primary cultures of bovine adrenal chromaffin cells by angiotensin II, histamine, bradykinin, and carbachol. J Neurochem. 1988 Aug;51(2):634-41.

[3]Keles N, Yavuz Arican R, Coskun M, Elpek GO. Histamine induces the neuronal hypertrophy and increases the mast cell density in gastrointestinal tract. Exp Toxicol Pathol. 2012 Nov;64(7-8):713-6

[4]Wang Z, Wang D, Yu Y, Li Y, Sui Y, Cui H. [Experimental model of histamine-induced anaphylactoid reaction on beagle dogs]. Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(14):1842-4. Chinese

[5]Norberg HP, Schulak JA, Atlas B, Kaplan EL. Histamine-induced hypocalcemia in the rat. Metabolism. 1976 Feb;25(2):131-4

[6]Tremblay C, Lemire I, Ghezzo H, Pineau L, Martin RR, Cartier A, Malo JL. Histamine phosphate has a cumulative effect when inhaled at five minute intervals. Thorax. 1984 Dec;39(12):946-51