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/ Histamine 2HCl

二盐酸组胺 /Histamine 2HCl {[allProObj[0].p_purity_real_show]}

货号：A211645 同义名： 组胺二盐酸盐 / Ceplene;Histamine dihydrochloride

Histamine 2HCl is the 2HCl form of histamine which is an organic nitrogen compound that articipates in immune responses and inflammatory reactions and also can be used as neurotransmitters

Histamine 2HCl 化学结构 CAS号：56-92-8
Histamine 2HCl 化学结构
CAS号：56-92-8
Histamine 2HCl 3D分子结构
CAS号：56-92-8
Histamine 2HCl 化学结构 CAS号：56-92-8
Histamine 2HCl 3D分子结构 CAS号：56-92-8
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Histamine 2HCl 纯度/质量文件 产品仅供科研

货号：A211645 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine dihydrochloride ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 98%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		98%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		98%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 98%
Levodropropizine ✔ 97%
Cyproheptadine hydrochloride ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin hydrochloride ✔ 99+%
Buclizine 2HCl ✔ 97%
Latrepirdine 2HCl ✔ GluR 98%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Histamine 2HCl 生物活性

描述 Histamine dihydrochloride (Ceplene) is a synthetic derivative of the biogenic amine histamine. Histamine dihydrochloride inhibits the formation of reactive oxygen species (ROS) that suppress the activation of T cells and natural killer cells. Histamine dihydrochloride and IL-2 as maintenance therapy significantly prolonged LFS (longer leukaemia-free survival) compared with no treatment and had an acceptable tolerability profile in a large phase III trial in patients with AML (acute myeloid leukaemia)[3]. Clinical trials in solid tumors and in AML have demonstrated the potential to improve treatment outcome when histamine dihydrochloride is combined with immunotherapy[4]. In vitro ROS detection assays proved that the HDC (histamine dihydrochloride) loaded graphene nanoplatform could effectively inhibit ROS and thus prevent the immunosuppression caused by leukemic cells[5].

Histamine 2HCl 参考文献

[1]Hornyak SC, Gehlsen KR, Haaparanta T. Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model. Inflammation. 2003 Oct;27(5):317-27.

[2]Agarwala SS, Sabbagh MH. Histamine dihydrochloride: inhibiting oxidants and synergising IL-2-mediated immune activation in the tumour microenvironment. Expert Opin Biol Ther. 2001 Sep;1(5):869-79.

[3]Yang LP, Perry CM. Histamine dihydrochloride: in the management of acute myeloid leukaemia. Drugs. 2011 Jan 1;71(1):109-22

[4]Perz JB, Ho AD. Histamine dihydrochloride for the treatment of acute myeloid leukemia, malignant melanoma and renal cell carcinoma. Future Oncol. 2008 Apr;4(2):169-77

[5]Cherukula K, Nurunnabi M, Jeong YY, Lee YK, Park IK. A targeted graphene nanoplatform carrying histamine dihydrochloride for effective inhibition of leukemia-induced immunosuppression. J Biomater Sci Polym Ed. 2018 May-Jun;29(7-9):734-749

Histamine 2HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.43mL

1.09mL

0.54mL

27.16mL

5.43mL

2.72mL

54.33mL

10.87mL

5.43mL

Histamine 2HCl 技术信息

CAS号56-92-8
分子式C5H11Cl2N3
分子量 184.067
别名 组胺二盐酸盐 ;Ceplene;Histamine dihydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 105 mg/mL(570.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Histamine | 56-92-8 | Induced Disease Models Products | Metabolic Enzyme/Protease | Immunology and Inflammatory Disease Models | Digestive System Disease Models | Endogenous Metabolite | Gastrointestinal Inflammation and Ulcer Models | Gastrointestinal Disease Models | Gastric Ulcer Models | Duodenal Ulcer Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Histamine 2HCl 纯度/质量文件 | Histamine 2HCl 亚型比较 | Histamine 2HCl 生物活性 | Histamine 2HCl 参考文献 | Histamine 2HCl 实验方案 | Histamine 2HCl 技术信息

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