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/ Histamine 2HCl

二盐酸组胺 /Histamine 2HCl {[allProObj[0].p_purity_real_show]}

货号：A211645 同义名： 组胺二盐酸盐 / Ceplene;Histamine dihydrochloride

Histamine 2HCl是一种活性氧抑制剂，通过协同 IL-2 激活 T 细胞和 NK 细胞，表现出免疫激活和抗肿瘤作用，适用于急性髓性白血病和恶性黑色素瘤研究。

Histamine 2HCl 化学结构 CAS号：56-92-8
Histamine 2HCl 化学结构
CAS号：56-92-8
Histamine 2HCl 3D分子结构
CAS号：56-92-8
Histamine 2HCl 化学结构 CAS号：56-92-8
Histamine 2HCl 3D分子结构 CAS号：56-92-8
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Histamine 2HCl 纯度/质量文件 产品仅供科研

货号：A211645 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine dihydrochloride ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 98%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		99%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

rat H3 receptor, Ki: 1.44 μM

human H3 receptor, Ki: 1.2 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		99%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 99%
Levodropropizine ✔ 97%
Cyproheptadine hydrochloride ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin hydrochloride ✔ 99+%
Buclizine 2HCl ✔ 97%
Latrepirdine 2HCl ✔ GluR 99%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Histamine 2HCl 生物活性

描述 Histamine dihydrochloride (Ceplene) is a synthetic derivative of the biogenic amine histamine. Histamine dihydrochloride inhibits the formation of reactive oxygen species (ROS) that suppress the activation of T cells and natural killer cells. Histamine dihydrochloride and IL-2 as maintenance therapy significantly prolonged LFS (longer leukaemia-free survival) compared with no treatment and had an acceptable tolerability profile in a large phase III trial in patients with AML (acute myeloid leukaemia)[3]. Clinical trials in solid tumors and in AML have demonstrated the potential to improve treatment outcome when histamine dihydrochloride is combined with immunotherapy[4]. In vitro ROS detection assays proved that the HDC (histamine dihydrochloride) loaded graphene nanoplatform could effectively inhibit ROS and thus prevent the immunosuppression caused by leukemic cells[5].

Histamine 2HCl 参考文献

[1]Hornyak SC, Gehlsen KR, Haaparanta T. Histamine dihydrochloride protects against early alcohol-induced liver injury in a rat model. Inflammation. 2003 Oct;27(5):317-27.

[2]Agarwala SS, Sabbagh MH. Histamine dihydrochloride: inhibiting oxidants and synergising IL-2-mediated immune activation in the tumour microenvironment. Expert Opin Biol Ther. 2001 Sep;1(5):869-79.

[3]Yang LP, Perry CM. Histamine dihydrochloride: in the management of acute myeloid leukaemia. Drugs. 2011 Jan 1;71(1):109-22

[4]Perz JB, Ho AD. Histamine dihydrochloride for the treatment of acute myeloid leukemia, malignant melanoma and renal cell carcinoma. Future Oncol. 2008 Apr;4(2):169-77

[5]Cherukula K, Nurunnabi M, Jeong YY, Lee YK, Park IK. A targeted graphene nanoplatform carrying histamine dihydrochloride for effective inhibition of leukemia-induced immunosuppression. J Biomater Sci Polym Ed. 2018 May-Jun;29(7-9):734-749

Histamine 2HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.43mL

1.09mL

0.54mL

27.16mL

5.43mL

2.72mL

54.33mL

10.87mL

5.43mL

Histamine 2HCl 技术信息

CAS号56-92-8
分子式C5H11Cl2N3
分子量 184.067
别名 组胺二盐酸盐 ;Ceplene;Histamine dihydrochloride
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,Room Temperature
溶解度

DMSO: 105 mg/mL(570.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Histamine | 56-92-8 | Induced Disease Models Products | Metabolic Enzyme/Protease | Immunology and Inflammatory Disease Models | Digestive System Disease Models | Endogenous Metabolite | Gastrointestinal Inflammation and Ulcer Models | Gastrointestinal Disease Models | Gastric Ulcer Models | Duodenal Ulcer Models | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Histamine 2HCl 纯度/质量文件 | Histamine 2HCl 亚型比较 | Histamine 2HCl 生物活性 | Histamine 2HCl 参考文献 | Histamine 2HCl 实验方案 | Histamine 2HCl 技术信息

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