产品说明书
Histamine 2HCl
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同义名 : | 组胺二盐酸盐 ;Ceplene;Histamine dihydrochloride |
| CAS号 : | 56-92-8 | |
| 货号 : | A211645 | |
| 分子式 : | C5H11Cl2N3 | |
| 纯度 : | 98% | |
| 分子量 : | 184.067 | |
| MDL号 : | MFCD00012703 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(570.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Histamine dihydrochloride (Ceplene) is a synthetic derivative of the biogenic amine histamine. Histamine dihydrochloride inhibits the formation of reactive oxygen species (ROS) that suppress the activation of T cells and natural killer cells. Histamine dihydrochloride and IL-2 as maintenance therapy significantly prolonged LFS (longer leukaemia-free survival) compared with no treatment and had an acceptable tolerability profile in a large phase III trial in patients with AML (acute myeloid leukaemia)[3]. Clinical trials in solid tumors and in AML have demonstrated the potential to improve treatment outcome when histamine dihydrochloride is combined with immunotherapy[4]. In vitro ROS detection assays proved that the HDC (histamine dihydrochloride) loaded graphene nanoplatform could effectively inhibit ROS and thus prevent the immunosuppression caused by leukemic cells[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.43mL 1.09mL 0.54mL |
27.16mL 5.43mL 2.72mL |
54.33mL 10.87mL 5.43mL |
| 参考文献 |
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