4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.

SEN177是一种高效的谷氨酰胺环化酶 (QPCT) 抑制剂，对 QPCTL 的 IC₅₀ 值为 0.013 μM，Ki 为 20 nM。它能显著减少亨廷顿病 (HD) 中突变型 HTT 的寡聚化，并降低神经元中 Q80 聚集体的百分比，具有用于亨廷顿病研究的潜力。

PQM130是一种具有脑屏障透过性的魏罗酮-多奈哌齐杂化化合物，作为多靶点的候选活性分子，可用于研究 Aβ1-42 低聚物引起的神经毒性，并具有抗炎活性。PQM130 是一种具有神经保护作用的潜力抗 AD 活性分子。

Methoxy-X04是一种能够透过血脑屏障的荧光染料，选择性结合于阿尔茨海默症 (AD) 脑中致密核心Aβ淀粉样斑块的β-折叠结构，具有优异的荧光特性，可用于研究AD病理。其对Aβ原纤维的Ki值为26.8 nM。

Tabersonine是从马达加斯加长春花中分离出的吲哚生物碱，可以破坏Aβ(1-42)的聚集并改善Aβ聚集诱导的细胞毒性。Tabersonine还具有抗炎活性，可用于急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）的研究。

Colivelin TFA被认为是一种脑渗透神经保护肽，是STAT3的有效激活剂，通过体外激活STAT3有效抑制神经元死亡。此外，Colivelin TFA对神经毒性、Aβ沉积、神经元凋亡和与神经退行性疾病相关的突触可塑性缺陷表现出持久的有益效果。它在治疗阿尔茨海默病和缺血性脑损伤方面具有潜力。

Schisandrone 是从五味子干果中分离出的 4-芳基四氢呋喃木脂素，是一种 α-溶血素（Hla）抑制剂，可以下调 hla、agrA 和 RNAIII 的转录水平。

DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE, has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.

Crocetin monomethyl ester具有抗炎、神经保护和抗氧化作用，能通过STK11/LKB1介导的AMPK通路诱导自噬，促进淀粉样蛋白β的清除。

EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.

Amyloid-beta (Abeta) Protein Aggregation Inhibitors, Antiamyloidogenic Agents

PE859 is a Curcumin-derived inhibitor of Amyloid-β and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8.

Scyllo-Inositol is a naturally occurring isomer of myo-inositol.

Frentizole, an immunosuppressive drug, is an inhibitor of the Aβ-ABAD interaction.

Aftin-4 是 β-淀粉样蛋白42 (Aβ42) 的诱导剂。

LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.

FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells.

Licochalcone B提取自 Glycyrrhiza uralensis 根部，能有效抑制淀粉样蛋白 β (Aβ42) 的自聚集，并分解已形成的 Aβ42 原纤维。它通过螯合金属离子减少 Aβ42 聚集，并在 LPS 信号通路中抑制 NF-κB p65 磷酸化。此外，Licochalcone B 能抑制非小细胞肺癌 (NSCLC) 细胞的生长，诱导凋亡，并通过破坏 NEK7-NLRP3 相互作用来抑制 NLRP3 炎症小体。

2-D08 是一种可透细胞的小泛素样修饰蛋白 (sumoylation) 抑制剂，亦可抑制 Axl，IC50 为 0.49 nM。