Eriodictyol | Huazhongilexone | Endogenous Metabolite | AmBeed-信号通路专用抑制剂

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圣草酚 /Eriodictyol {[allProObj[0].p_purity_real_show]}

货号：A404191 同义名： Huazhongilexone;2S-Eriodictyol

Eriodictyol, a flavonoid isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with anti-inflammatory and antioxidant activities, may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance and be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness in Atopic dermatitis.

Eriodictyol 化学结构
CAS号：552-58-9

Eriodictyol 3D分子结构
CAS号：552-58-9

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Eriodictyol 纯度/质量文件产品仅供科研

货号：A404191 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^full-length, IC50: 2.98 μM BLM^636-1298, IC50: 0.97 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					97%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				97%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, IC50: 46.11 nM Leucyl-tRNA synthetase, Kd: 42.1 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Eriodictyol 生物活性

描述

Eriodictyol is a flavonoid extracted from the North American plant yerba santa, with antioxidant and anti-inflammatory activity. Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues^[3]. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons^[4]. Eriodictyol dose- and time-dependently suppresses cell proliferation, migration, and invasion in U87MG and CHG-5 glioma cells. In addition, eriodictyol induces apoptosis in U87MG and CHG-5 cells. Furthermore, eriodictyol downregulates the phosphoinositide 3-kinase (PI3K)/Akt/NF-κB signaling pathway in a concentration-dependent manner^[5]. The proliferation rate of CNE1 cells was reduced in eriodictyol dose-dependently. Cell colonies were also observed to be minimised after eriodictyol exposure. Cell migration and invasion was significantly suppressed by eriodictyol in CNE1 cells^[6].

Eriodictyol 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03482401	Breast Cancer	Not Applicable	Active, not recruiting	June 1, 2019	Spain ... 展开 >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 收起 <<
NCT02627547	Healthy	Not Applicable	Completed	-	United Kingdom ... 展开 >> University of Glasgow School of Medicine Glasgow, United Kingdom 收起 <<
NCT03215043	Pre Diabetes	Not Applicable	Recruiting	June 28, 2019	Brazil ... 展开 >> Sao Paulo State University "Julio de Mesquita Filho", Faculdade de Ciências Farmacêuticas Recruiting Araraquara, Sao Paulo, Brazil, 14800-903 Contact: Thais B Cesar, Ph.D. +55 16 3301-6927 tcesar@fcfar.unesp.br 收起 <<

Eriodictyol 参考文献

[1]Zhu S, Wu J, et al. Efficient synthesis of eriodictyol from L-tyrosine in Escherichia coli. Appl Environ Microbiol. 2014 May;80(10):3072-80.

[2]Lee E, Jeong KW, et al. Binding model for eriodictyol to Jun-N terminal kinase and its anti-inflammatory signaling pathway. BMB Rep. 2013 Dec;46(12):594-9.

[3]Zhu GF, Guo HJ, Huang Y, Wu CT, Zhang XF. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp Ther Med. 2015 Dec;10(6):2259-2266

[4]Jing X, Shi H, Zhu X, Wei X, Ren M, Han M, Ren D, Lou H. Eriodictyol Attenuates β-Amyloid 25-35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2. Neurochem Res. 2015 Jul;40(7):1463-71

[5]Li W, Du Q, Li X, Zheng X, Lv F, Xi X, Huang G, Yang J, Liu S. Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway. Front Pharmacol. 2020 Feb 25;11:114

[6]Tang L, Qin Y, Ling K, Wan H. Eriodictyol inhibits the growth of CNE1 human nasopharyngeal cancer growth by targeting MEK/ERK signalling pathway, inducing cellular autophagy and inhibition of cell migration and invasion. J BUON. 2020 Sep-Oct;25(5):2389-2394

Eriodictyol 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.47mL

0.69mL

0.35mL

17.35mL

3.47mL

1.73mL

34.69mL

6.94mL

3.47mL

Eriodictyol 技术信息

CAS号	552-58-9
分子式	C₁₅H₁₂O₆
分子量	288.252

别名	Huazhongilexone;2S-Eriodictyol;(+)-Eriodictyol
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 120 mg/mL(416.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

圣草酚 /Eriodictyol {[allProObj[0].p_purity_real_show]}

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圣草酚 /Eriodictyol {[allProObj[0].p_purity_real_show]}

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Eriodictyol 技术信息

最近浏览的产品

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总药量计算器

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Eriodictyol 纯度/质量文件产品仅供科研