NXPZ-2是一种口服活性的 Keap1-Nrf2 PPI 抑制剂，Ki 为 95 nM，EC50 为 120 和 170 nM。它能够剂量依赖性地减轻 Aβ[1-42] 诱导的认知障碍，并通过增加神经元数量和功能改善阿尔茨海默病 (AD) 小鼠的脑病理状态。

Omaveloxolone（RTA 408）是一种抗氧化炎症调节剂（AIM），可以激活Nrf2并抑制一氧化氮（NO）。它通过抑制STING依赖的NF-κB信号传导来减轻破骨细胞生成。

Garcinone D是一种来自山竹的天然呫吨酮 (xanthone)，能够促进神经干细胞 C17.2 的增殖。该化合物以浓度和时间依赖的方式增加磷酸化信号转导子和转录激活因子 3 (p-STAT3)，Cyclin D1，Nrf2，及 HO-1 的蛋白水平，具有神经保护和抗氧化潜力。

KI696 异构体是 KI696 的低活性异构体。KI696 是一种高亲和力探针，可破坏 Keap1/NRF2 互作。

Keap1-Nrf2-IN-13是一种 Keap1-Nrf2 蛋白质相互作用抑制剂，IC₅₀ 值为 0.15 μM，能够与 Keap1 的关键残基形成氢键，调控 Nrf2 的氧化应激应答通路，广泛用于肺纤维化、COPD 和癌症等氧化应激相关疾病的研究。

Oxysophocarpine, a natural product isolated and purified from the root of Styphnolobium japonicum (L.) Schott., can decrease the level of serum transaminase, improve lipid metabolism, reduce synthesis of inflammatory cytokines TNF-α, TGF-β1 and IL-6, activate protective adipocytokine adiponectin, and may be a drug for colonic inflammation and NASH.

Nrf2-IN-1是一种 Nrf2 抑制剂，主要用于急性髓性白血病 (AML) 的研究，通过调控氧化应激途径，发挥潜在的抗癌作用。

ML385 是一种 Nrf2 抑制剂，能够抑制 Nrf2 的转录活性，IC50 值为 1.9 μM。ML385 具有抗氧化应激和抗肿瘤作用，可用于癌症和氧化应激相关疾病的研究。

(+)-Corynoline is an AChE inhibitor isolated from Corydalis incisa.

4-Octyl itaconate is the endogenous metabolite of itaconate with anti-inflammatory activity. It can decrease cytokine production and protect against lipopolysaccharide-induced lethality in vivo.

Kinsenoside是从开唇兰属植物中分离的主要活性成分，具有抗氧化和保护髓核细胞 (NPC) 的作用。该化合物通过激活 AKT-ERK1/2-Nrf2 信号通路防止细胞凋亡和线粒体功能障碍，适用于椎间盘退变（IDD）的研究。

(R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer.

RA-839 is a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. RA-839 also suppresses LPS-induced iNOS and nitric oxide expression in macrophages.

Eriodictyol, a flavonoid isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with anti-inflammatory and antioxidant activities, may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance and be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness in Atopic dermatitis.

4-Hydroxy-3-methoxycinnamaldehyde is an isoflavonoid isolated and purified from Senra incana with anti-apoptosis activity.

Eriodictyol-7-O-glucoside, a natural product isolated and purified from the herbs of Dracocephalum rupestre, can activate Nrf2/ARE signaling, directly associated with its neuroprotection against oxidative stress-induced ischemic, suggesting that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke.

KI696是一种高亲和力探针，通过干扰Keap1/NRF2相互作用，作为该通路的高效且选择性抑制剂。

NK-252 is a Nrf2 activator, exhibits a greater Nrf2-activating potential than OPZ.

Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator which induces upregulation of antioxidant gene expression.

Carnosol, a natural product isolated and purified from the herbs of Rosmarinus officinalis L., enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as an agonist of TRPA1 with an EC50 value of 12.46 µM.