Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1].
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Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, which is a histamine H2-receptor antagonist. Cimetidine exhibits potential for the treatment of peptic ulcer disease and upper gastrointestinal hemorrhage [1].
体内研究
The enantiomeric profile of Cimetidine sulfoxide is analyzed in rat urine collected over 24 hours after the oral administration of Cimetidine (30 mg/kg) to male Wistar rats. The resulting enantiomeric ratio is determined to be (+/−) 57:43 [3].
体外研究
Active transport of Cimetidine across the rat small intestine is evident at lower substrate concentrations (40 and 200 μM), but becomes obscured by passive transfer at higher concentrations (400 μM). Detection of Cimetidine sulfoxide occurs after certain incubation periods [2].
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