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Cimetidine sulfoxide

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Chemical Structure| 54237-72-8 同义名 : Cimetidine sulphoxide
CAS号 : 54237-72-8
货号 : A1365596
分子式 : C10H16N6OS
纯度 : 98%+
分子量 : 268.339
MDL号 : MFCD09753816
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(316.76 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, which is a histamine H2-receptor antagonist. Cimetidine exhibits potential for the treatment of peptic ulcer disease and upper gastrointestinal hemorrhage [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.63mL

3.73mL

1.86mL

37.27mL

7.45mL

3.73mL
参考文献

[1]Larsson R, et al. The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol. 1982;13(2):163-170.

[2]HE Barber, et al. The Transport of Cimetidine Across the Rat Small Intestine in Vitro. B r J Pharmacol. 1979 Jul;66(3):496P-497P.

[3]Ryta A. Kuzel, et al. Investigations into the chirality of the metabolic sulfoxidation of cimetidine. Chirality (1994), 6(8), 607-14.