Sofosbuvir | GS-7977;PSI-7977;Resof;Hepcvir;Hepcinat;Vosevi;Virunon;Sovaldi;GI-7977 | Antivirus | HCV | DNA/RNA Synthesis

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索非布韦 /Sofosbuvir {[allProObj[0].p_purity_real_show]}

货号：A298621 同义名： GS-7977;PSI-7977

Sofosbuvir（GS-7977）是一种HCV RNA复制抑制剂，EC50为92 nM。

Sofosbuvir 化学结构
CAS号：1190307-88-0

Sofosbuvir 3D分子结构
CAS号：1190307-88-0

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Sofosbuvir 纯度/质量文件产品仅供科研

货号：A298621 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^636-1298, IC50: 0.97 μM BLM^full-length, IC50: 2.98 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					99%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				99%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, Kd: 42.1 nM Leucyl-tRNA synthetase, IC50: 46.11 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Sofosbuvir 生物活性

描述

Sofosbuvir (GS-7977) is an inhibitor of HCV RNA replication, with an EC50 of 92 nM^[1].

体外研究

When cathepsin A (CatA) is exposed to PSI-7977 or Sofosbuvir (PSI-7977) for 150 minutes, approximately 18-fold more PSI-352707 is produced compared to PSI-7976 when Sofosbuvir (PSI-7977) is the substrate. Furthermore, the catalytic efficiency of Sofosbuvir (PSI-7977) with CatA is approximately 30-fold higher than that of PSI-7976^[1].

The genotype coverage of Sofosbuvir (PSI-7977) is evaluated using replicons derived from GT 1b (Con1), 1a (H77), and 2a (JFH-1), as well as chimeric replicons containing the NS5B region from the J6 GT 2a isolate and from GT 2b and GT 3a patient isolates. Sofosbuvir (PSI-7977) inhibits the replication of these replicons with similar EC50s (between 16 and 48 nM) and is particularly effective against the chimeric replicon containing the J6 NS5B (EC50=4.7 nM). It also inhibits clone A (GT 1b) wild-type and S282T replicons with EC90 values of 0.42 and 7.8 μM, respectively^[2].

In the clone A replicon assay, Sofosbuvir (PSI-7977) exhibits anti-HCV activity with EC90 values of 0.42 μM[3].

Sofosbuvir 参考文献

[1]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.

[2]Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.

Sofosbuvir 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.44mL

1.89mL

0.94mL

18.89mL

3.78mL

1.89mL

Sofosbuvir 技术信息

CAS号	1190307-88-0
分子式	C₂₂H₂₉FN₃O₉P
分子量	529.452

别名	GS-7977;PSI-7977;Resof;Hepcvir;Hepcinat;Vosevi;Virunon;Sovaldi;GI-7977
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 50 mg/mL(94.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 25 mg/mL(47.22 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验配方

索非布韦 /Sofosbuvir {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

Sofosbuvir 质控信息

Sofosbuvir 生物活性

Sofosbuvir 参考文献

Sofosbuvir 实验方案

Sofosbuvir 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

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