Sofosbuvir

产品说明书

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Chemical Structure| 1190307-88-0 同义名 : GS-7977;PSI-7977;Resof;Hepcvir;Hepcinat;Vosevi;Virunon;Sovaldi;GI-7977
CAS号 : 1190307-88-0
货号 : A298621
分子式 : C22H29FN3O9P
纯度 : 99%
分子量 : 529.452
MDL号 : MFCD26523124
存储条件:

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(94.44 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 25 mg/mL(47.22 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方:
生物活性
描述 Sofosbuvir (GS-7977) is an inhibitor of HCV RNA replication, with an EC50 of 92 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.44mL

1.89mL

0.94mL

18.89mL

3.78mL

1.89mL

参考文献

[1]Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47.

[2]Lam AM, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.