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5-羟色胺受体
炎症模型 疼痛和瘙痒模型 神经递质
/ Serotonin HCl

血清胺盐酸盐 /Serotonin HCl {[allProObj[0].p_purity_real_show]}

货号：A570248 同义名： 5-羟基色胺盐酸盐 / 5-Hydroxytryptamine hydrochloride;5-HT hydrochloride

Serotonin HCl是一种内源性的5-HT受体激动剂。

Serotonin HCl 化学结构 CAS号：153-98-0
Serotonin HCl 化学结构
CAS号：153-98-0
Serotonin HCl 3D分子结构
CAS号：153-98-0
Serotonin HCl 化学结构 CAS号：153-98-0
Serotonin HCl 3D分子结构 CAS号：153-98-0
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Serotonin HCl 纯度/质量文件 产品仅供科研

货号：A570248 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 5-HT ↓ 5-HT1 ↓ 5-HT2 ↓ 5-HT3 ↓ 5-HT5 ↓ 5-HT6 ↓ 5-HT7 ↓ 其他靶点 纯度
Desvenlafaxine ++

5-HT, Ki: 40.2 nM

 		98%
Lamotrigine +

5-HT (human platelets), IC50: 240 μM

5-HT (rat brain synaptosomes), IC50: 474 μM

 		98%
Venlafaxine ✔ 99%
Fluvoxamine maleate ✔ 99%
Iloperidone ✔ 99%
Ziprasidone HCl ✔ 98+%
Atomoxetine HCI +

5-HT, Ki: 77 nM

 		98%
Dapoxetine HCl ✔ 97%
Trazodone ✔ 98+%
Clomipramine HCl ✔ 98%
Mirtazapine ✔ 99+%
Escitalopram oxalate +++

5-HT, Ki: 0.89 nM

 		97%
Duloxetine ✔ 98+%
Sertraline HCl ++

5-HT, Ki: 13 nM

 		98%
Citalopram HBr +++

serotonin reuptake, IC50: 1.8 nM

 		98%
Latrepirdine 2HCl ✔ GluR 99%
Fluoxetine HCl ✔ 99.5%
Paroxetine hydrochloride ✔ AChR 99%
BMY 7378 ++

5-HT1D, pIC50: 5.9

5-HT1A, pIC50: 6.4

 		+

5-HT2, pIC50: 5.5

 		97%
Flibanserin +++

5-HT1A, Ki: 1 nM

 		+

5-HT2A, Ki: 49 nM

 		98%
LY310762 +

5-HT1D, Ki: 249 nM

 		99%+
Cyclobenzaprine HCI ✔ 99%
Blonanserin +++

5-HT2, Ki: 3.98 nM

 		99%
Cyproheptadine HCl ++++

5-HT2, IC50: 0.6 nM

 		99+%
Olanzapine ✔ 99+%
Pimavanserin hemitartrate +++

5-HT2A, pIC50: 8.7

 		99%
Ketanserin +++

5-HT2C (Rat), Ki: 50 nM

5-HT2C (Human), Ki: 2.5 nM

 		99%+
Loxapine succinate ++

5-HT2 (bovine), Ki: 6.6 nM

5-HT2 (human), Ki: 6.8 nM

 		99%
Agomelatine ✔ 98%
Clozapine ✔ 98%
Amitriptyline +

5-HT2, Ki: 235 nM

 		SERT 99%
PRX-08066 maleate +++

5-HT2B, IC50: 3.4 nM

 		98+%
RS-127445 ++++

5-HT2B, pIC50: 10.4

5-HT2B, pKi: 9.5

 		99%+
Sarpogrelate HCl ++++

5-HT2A, Kd: 2.1 nM

5-HT2C, Kd: 1.1 nM

 		98%
Tropisetron ✔ 99%
Ramosetron HCl ++++

5-HT3 receptor, Ki: 0.091 nM

 		98%
Ondansetron ✔ 99%
Granisetron ✔ 98%
Alosetron HCl ✔ 98%
Ondansetron hydrochloride dihydrate ✔ 98%
VUF10166 ++++

5-HT3A, Ki: 0.04 nM

5-HT3AB, Ki: 22 nM

 		99%+
Azasetron hydrochloride ++++

5-HT3, IC50: 0.33 nM

 		99%
Asenapine maleate +++

5-HT1A, pKi: 8.6

5-HT1B, pKi: 8.4

 		++++

5-HT2A, pKi: 9.75

5-HT2C, pKi: 10.46

 		+++

5-HT5A, pKi: 8.84

 		++++

5-HT6, pKi: 9.6

 		++++

5-HT7, pKi: 9.94

 		97%
Risperidone ++

5-HT1D, Ki: 84.6 nM

5-HT1B, Ki: 14.9 nM

 		++++

5-HT2C, Ki: 12 nM

5-HT2A, Ki: 61.9 nM

 		+

5-HT5A, Ki: 206 nM

 		++

5-HT7, Ki: 6.6 nM

 		98%
SB 271046 HCl +++

5-HT6, pKi: 8.92

 		99%+
Intepirdine ++++

5-HT6, pKi: 9.63

 		99%+
SB-269970 HCl ++

5-HT7, pKi: 8.3

 		98+%
BRL 15572 ++

5-HT1B, pKi: 6.1

5-HT1D, pKi: 6

 		++

5-HT2A, pKi: 6.6

5-HT2B, pKi: 6.2

 		+

5-HT6, pKi: 5.9

 		+

5-HT7, pKi: 6.3

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Serotonin HCl 生物活性

描述 Serotonin hydrochloride, the hydrochloride form of serotonin (5-HT), plays an important role in humans’ neural action and could interact with 5-HT receptor. In vitro studies, high level of serotonin could disturb the process of oligodendrocyte (OL) development, induce cell injury and inhibit myelination deficit in OL. Besides this, it was found that serotonin could also initiate a depolarizing inward current and accelerate spontaneous firing in about 80% of the lateral habenula (LHb) neurons in rat brain slices. In vivo studies, serotonin plus N(ω)-nitro-l-arginine methyl ester hydrochloride (l-NAME) could contribute to the improvement of inward remodeling processes in rat cremasteric feed arterioles (100-200 μm lumen diameter), through the activationactivate of transglutaminases and Lim kinase, as well as modulate the phosphorylation of cofilin.

Serotonin HCl 动物研究

Dose Rat: 1 mg/kg - 4 mg/kg (i.p.)
Administration i.p.

Serotonin HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00005024 Unspecified Adult Solid Tumor,... 展开 >> Protocol Specific 收起 << Phase 3 Unknown - -
NCT02604797 C.Delivery; Surgery (Previous)... 展开 >>, Gynecological 收起 << Not Applicable Unknown January 2018 -
NCT01316926 - Completed - -

Serotonin HCl 参考文献

[1]Zuo W, Zhang Y, et al. Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels. Neuropharmacology. 2016 Feb;101:449-59.

[2]Fan LW, Bhatt A, et al. Exposure to serotonin adversely affects oligodendrocyte development and myelination in vitro. J Neurochem. 2015 May;133(4):532-43.

Serotonin HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.70mL

0.94mL

0.47mL

23.51mL

4.70mL

2.35mL

47.02mL

9.40mL

4.70mL

Serotonin HCl 技术信息

CAS号153-98-0
分子式C10H13ClN2O
分子量 212.676
别名 5-羟基色胺盐酸盐 ;5-Hydroxytryptamine hydrochloride;5-HT hydrochloride;5-Hydroxytryptamine;5-HT;Serotonin (hydrochloride);Serotonin HCl
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,2-8°C
溶解方案

DMSO: 120 mg/mL(564.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(470.2 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

PO 0.5% CMC-Na 36 mg/mL clear

Tags: Serotonin HCl | 5-Hydroxytryptamine hydrochloride;5-HT hydrochloride;5-Hydroxytryptamine;5-HT;Serotonin (hydrochloride);Serotonin HCl | 5-羟基色胺盐酸盐 | Inflammation Model | Pain and Pruritus Model | Neurotransmitter | 5-HT Receptor | AmBeed-信号通路专用抑制剂 | Serotonin HCl 纯度/质量文件 | Serotonin HCl 亚型比较 | Serotonin HCl 生物活性 | Serotonin HCl 动物研究 | Serotonin HCl 临床数据 | Serotonin HCl 参考文献 | Serotonin HCl 实验方案 | Serotonin HCl 技术信息

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