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Serotonin HCl

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Chemical Structure| 153-98-0 同义名 : 5-羟基色胺盐酸盐 ;5-Hydroxytryptamine hydrochloride;5-HT hydrochloride;5-Hydroxytryptamine;5-HT;Serotonin (hydrochloride);Serotonin HCl
CAS号 : 153-98-0
货号 : A570248
分子式 : C10H13ClN2O
纯度 : 99+%
分子量 : 212.676
MDL号 : MFCD00012686
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(564.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(470.2 mM)，配合低频超声助溶
动物实验配方：

PO 0.5% CMC-Na 36 mg/mL clear

生物活性
描述 Serotonin hydrochloride, the hydrochloride form of serotonin (5-HT), plays an important role in humans’ neural action and could interact with 5-HT receptor. In vitro studies, high level of serotonin could disturb the process of oligodendrocyte (OL) development, induce cell injury and inhibit myelination deficit in OL. Besides this, it was found that serotonin could also initiate a depolarizing inward current and accelerate spontaneous firing in about 80% of the lateral habenula (LHb) neurons in rat brain slices. In vivo studies, serotonin plus N(ω)-nitro-l-arginine methyl ester hydrochloride (l-NAME) could contribute to the improvement of inward remodeling processes in rat cremasteric feed arterioles (100-200 μm lumen diameter), through the activationactivate of transglutaminases and Lim kinase, as well as modulate the phosphorylation of cofilin.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00005024 Unspecified Adult Solid Tumor,... 展开 >> Protocol Specific 收起 << Phase 3 Unknown - -
NCT02604797 C.Delivery; Surgery (Previous)... 展开 >>, Gynecological 收起 << Not Applicable Unknown January 2018 -
NCT01316926 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.70mL

0.94mL

0.47mL

23.51mL

4.70mL

2.35mL

47.02mL

9.40mL

4.70mL
参考文献

[1]Zuo W, Zhang Y, et al. Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels. Neuropharmacology. 2016 Feb;101:449-59.

[2]Fan LW, Bhatt A, et al. Exposure to serotonin adversely affects oligodendrocyte development and myelination in vitro. J Neurochem. 2015 May;133(4):532-43.