Rilmenidine Phosphate is an oxazole-derived agonist ofadrenergic receptor α2 and Imidazoline receptor, used in trials studying the treatment of hypertension and chronic kidney disease.
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
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Accessible (Haz class 3, 4, 5 or 8), International
α2-Adrenoceptors (α2-AR) found in the cardiomyocyte's sarcolemma represent a very important negative feedback for control of myocardial contractility by endogenous catecholamines[2]. Rilmenidine is a clinically approved anti-hypertensive agent that acts by activating ADRA2/α2-adrenoceptors and imidazoline-1 receptors (I1Rs) in the brain and periphery. It can be a mTOR-independent autophagy inducers. Stable inducible PC12 cells expressing either wild-type (23Q) or expanded polyglutamine (74Q) huntingtin both showed a significant increase in LC3-II (microtubule-associated protein 1 light chain) when treated with rilmenidine for 24 h[3]. Sinus rate, corrected sinus recovery time (CSRT) and Wenckebach point (WP) were measured in seven intact dogs. Atrial rate and atrial effective refractory period (AERP) were measured in six atrioventricular (AV)-blocked dogs with ventricular pacing. Each dog received with at least a three-day interval rilmenidine as dihydrogen phosphate in four successive intravenous injections, 30 min apart. In intact dogs, rilmenidine was administered at 50, 50, 100 and 200 μg/kg. In AV-blocked dogs, doses of rilmenidine were 25, 25, 50 and 100 μg/kg. Rilmenidine decreased sinus rate and atrial rate from the first dose. A lengthening of CSRT and a lowering of WP were observed at all doses with rilmenidine. A shortening of AERP was also seen with rilmenidine from the second dose[4].
Hypertension
... 展开 >>Hypertension Resistant to Conventional Therapy
Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent 收起 <<
Phase 4
Terminated
-
France
... 展开 >> Hopital Pasteur
Nice, Alpes-Maritimes, France, 06002
Hopital Saint Andre - CHU Bordeaux
Bordeaux, Gironde, France, 33075
Hopital Rangueil - CHU Toulouse
Toulouse, Haute-Garonne, France, 31059
Hopital Lapeyronie - CHU Montpellier
Montpellier, Herault, France, 34295
Hopital Arthur Gardiner
Dinard, Ille-et-Vilaine, France, 35800
Hopital Pontchaillou - CHU Rennes
Rennes, Ille-et-Vilaine, France, 35033
Groupe Hospitalier Mutualiste
Grenoble, Isere, France, 38028
Hopital Michallon - CHU Grenoble
La Tronche, Isere, France, 38700
Institut Lorrain du Cœur et des Vaisseaux Louis Mathieu
Vandoeuvre les Nancy, Meurthe-et-Moselle, France, 54500
Hopital de Brabois
Vandoeuvre les Nancy, Meurthe-et-Moselle, France, 54511
Hopital Cardiologique - CHRU Lille
Lille, Nord, France, 59037
CHU Clermont-Ferrand
Clermont-Ferrand, Puy-de-Dome, France, 63000
Hopital de la Croix-Rousse - CHU Lyon
Lyon, Rhone, France, 69004
Hopital de la Pitie Salpetriere
Paris, France, 75013
Hopital Europeen Georges Pompidou (HEGP)
Paris, France, 75015 收起 <<
Hypertension
... 展开 >>Hypertension Resistant to Conventional Therapy
Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent 收起 <<
Phase 4
Terminated
-
France
... 展开 >> Hopital Pasteur
Nice, Alpes-Maritimes, France, 06002
Hopital Saint Andre - CHU Bordeaux
Bordeaux, Gironde, France, 33075
Hopital Rangueil - CHU Toulouse
Toulouse, Haute-Garonne, France, 31059
Hopital Lapeyronie - CHU Montpellier
Montpellier, Herault, France, 34295
Hopital Arthur Gardiner
Dinard, Ille-et-Vilaine, France, 35800
Hopital Pontchaillou - CHU Rennes
Rennes, Ille-et-Vilaine, France, 35033
Groupe Hospitalier Mutualiste
Grenoble, Isere, France, 38028
Hopital Michallon - CHU Grenoble
La Tronche, Isere, France, 38700
Institut Lorrain du Cœur et des Vaisseaux Louis Mathieu
Vandoeuvre les Nancy, Meurthe-et-Moselle, France, 54500
Hopital de Brabois
Vandoeuvre les Nancy, Meurthe-et-Moselle, France, 54511
Hopital Cardiologique - CHRU Lille
Lille, Nord, France, 59037
CHU Clermont-Ferrand
Clermont-Ferrand, Puy-de-Dome, France, 63000
Hopital de la Croix-Rousse - CHU Lyon
Lyon, Rhone, France, 69004
Hopital de la Pitie Salpetriere
Paris, France, 75013
Hopital Europeen Georges Pompidou (HEGP)
Paris, France, 75015 收起 <<
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