盐酸萘哌地尔 /Naftopidil 2HCl
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货号：A127685
同义名：
BM-15275 dihydrochloride;KT-611 dihydrochloride
Naftopidil 2HCl 是一种选择性的 α1-肾上腺素受体拮抗剂，对 α1a、α1b 和 α1d 亚型的 Ki 值分别为 3.7 nM、20 nM 和 1.2 nM，主要用于治疗良性前列腺增生相关的下尿路症状。
Naftopidil 2HCl 化学结构
Naftopidil 2HCl 3D分子结构
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Naftopidil 2HCl 纯度/质量文件 产品仅供科研
货号：A127685
标准纯度：
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Naftopidil 2HCl 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
96%
Yohimbine HCI
✔
99+%
BMY 7378
++
α1D-adrenoceptor, pKi: 5.1
α2C-adrenoceptor, pKi: 6.54
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2A-adrenergic receptor, pKi: 8.9
α2B-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1D-adrenergic receptor, Ki: 20 nM
α1A-adrenergic receptor, Ki: 3.7 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
99%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
99%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β2-adrenergic receptor, Ki: 0.7nM
β1-adrenergic receptor, Ki: 611nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Naftopidil 2HCl 生物活性
靶点
描述
Naftopidil (Dihydrochloride), a selective α1-adrenergic receptor antagonist or alpha blocker, is an antihypertensive drug. Naftopidil significantly improved the overall international prostatic symptom score[3] [4] [5]
Naftopidil 2HCl 参考文献
[1] Kanda H, Ishii K, et al. Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer. 2008 Jan 15;122(2):444-51.
[2] Borbe HO, Metzenauer P, Szelenyi I. 5-HT1A-agonistic properties of naftopidil, a novel antihypertensive drug. Eur J Pharmacol. 1991 Nov 19;205(1):105-7.
[3] Sakai H, Igawa T, Onita T, Furukawa M, Hakariya T, Hayashi M, Matsuya F, Shida Y, Nishimura N, Yogi Y, Tsurusaki T, Takehara K, Nomata K, Shiraishi K, Shono T, Aoki D, Kanetake H. [Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication]. Hinyokika Kiyo. 2011 Jan;57(1):7-13. Japanese.
[4] Takei R, Ikegaki I, Shibata K, Tsujimoto G, Asano T. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54. doi: 10.1254/jjp.79.447. PMID: 10361884.
[5] Nakamura A, Matsunaga W, Gotoh A. Autophagy Induced by Naftopidil Inhibits Apoptosis of Human Gastric Cancer Cells. Anticancer Res. 2018 Feb;38(2):803-809.
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Naftopidil 2HCl 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.15mL
0.43mL
0.21mL
10.74mL
2.15mL
1.07mL
21.49mL
4.30mL
2.15mL
Naftopidil 2HCl 技术信息
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