盐酸伊伐布雷定 /Ivabradine HCl
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货号：A103870
同义名：
Ivabradine (hydrochloride);S 16257
vabradine HCl 是一种 HCN (超极化激活的环核苷酸门控) 通道阻滞剂，能够抑制心脏起搏器电流 (If)。Ivabradine HCl 具有抗惊厥、抗缺血和抗心绞痛活性，可用于心率控制相关的研究和治疗。
Ivabradine HCl 化学结构
Ivabradine HCl 3D分子结构
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Ivabradine HCl 纯度/质量文件 产品仅供科研
货号：A103870
标准纯度：
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产品说明书
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Ivabradine HCl 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
98%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2A-adrenergic receptor, pKi: 8.9
α2B-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2C, pKi: 7.2
adrenoceptor α2A, pKi: 7.1
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1A-adrenergic receptor, Ki: 3.7 nM
α1D-adrenergic receptor, Ki: 20 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
97%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
98%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Ivabradine HCl 生物活性
靶点
描述
Ivabradine Hydrochloride is a novel selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated channels, inducing heart rate (HR) reduction[3] [4] [5]
Ivabradine HCl 参考文献
[1] Lodhi M, Dubey A, et al. Formulation and evaluation of buccal film of Ivabradine hydrochloride for the treatment of stable angina pectoris. Int J Pharm Investig. 2013 Jan;3(1):47-53.
[2] Thollon C, Cambarrat C, et al. Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br J Pharmacol. 1994 May;112(1):37-42.
[3] Simko F, Baka T, Poglitsch M, Repova K, Aziriova S, Krajcirovicova K, Zorad S, Adamcova M, Paulis L. Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension. Int J Mol Sci. 2018 Oct 3;19(10):3017.
[4] Du XJ, Feng X, Gao XM, Tan TP, Kiriazis H, Dart AM. I(f) channel inhibitor ivabradine lowers heart rate in mice with enhanced sympathoadrenergic activities. Br J Pharmacol. 2004 May;142(1):107-12.
[5] Thollon C, Bedut S, Villeneuve N, Cogé F, Piffard L, Guillaumin JP, Brunel-Jacquemin C, Chomarat P, Boutin JA, Peglion JL, Vilaine JP. Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity. Br J Pharmacol. 2007 Jan;150(1):37-46.
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Ivabradine HCl 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.98mL
0.40mL
0.20mL
9.90mL
1.98mL
0.99mL
19.80mL
3.96mL
1.98mL
Ivabradine HCl 技术信息
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