货号:A272742 同义名: 阿夫唑嗪盐酸盐 / SL 77499-10;Alfuzosin (hydrochloride)
Alfuzosin HCl is an antagonist of α1 adrenergic receptor used to treat benign prostatic hyperplasia (BPH).
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产品名称 | Adrenergic Receptor ↓ ↑ | α-adrenergic receptor ↓ ↑ | β-adrenergic receptor ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ivabradine HCl | ✔ | 98% | |||||||||||||||||
Maprotiline hydrochloride | ✔ | 98% | |||||||||||||||||
Cisatracurium besylate | ✔ | 98% | |||||||||||||||||
Yohimbine HCI | ✔ | 99+% | |||||||||||||||||
BMY 7378 |
++
α1D-adrenoceptor, pKi: 5.1 α2C-adrenoceptor, pKi: 6.54 |
+
β1-adrenoceptor, pIC50: 5.1 |
97% | ||||||||||||||||
Asenapine maleate |
++++
α2A-adrenergic receptor, pKi: 8.9 α2B-adrenergic receptor, pKi: 8.9 |
97% | |||||||||||||||||
Piribedil |
++
adrenoceptor α2A, pKi: 7.1 adrenoceptor α2C, pKi: 7.2 |
98% | |||||||||||||||||
Prazosin HCl | ✔ | 95% | |||||||||||||||||
Silodosin | ✔ | 98% | |||||||||||||||||
Phenoxybenzamine HCl | ✔ | 98% | |||||||||||||||||
Naftopidil |
+++
α1D-adrenergic receptor, Ki: 20 nM α1A-adrenergic receptor, Ki: 3.7 nM |
98% | |||||||||||||||||
Naftopidil 2HCl |
+
α1-adrenergic receptor, IC50: 0.2 μM |
97% | |||||||||||||||||
Alfuzosin HCl | ✔ | 98% | |||||||||||||||||
Terazosin HCl | ✔ | 99% | |||||||||||||||||
Atipamezole | ✔ | 95% | |||||||||||||||||
Phentolamine methanesulfonate salt | ✔ | 99% | |||||||||||||||||
Doxazosin mesylate | ✔ | 98% | |||||||||||||||||
Tolazoline HCl | ✔ | 98% | |||||||||||||||||
Zenidolol hydrochloride |
++++
β2-adrenergic receptor, Ki: 0.7nM β1-adrenergic receptor, Ki: 611nM |
98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Alfuzosin hydrochloride is a selective and competitive α1-adrenoceptor antagonist for the treatment of symptomatic BPH (benign prostatic hyperplasia)[3]. In the pithed rat, alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibited pressor responses produced by the alpha 1-selective agonist; alfuzosin (1 mg kg-1, i.v.) had minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors[4]. Moreover, Alfuzosin hydrochloride is an appropriate candidate drug to prepare a gastro-retention controlled release dosage form[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01685658 | Renal Colic A... 展开 >>cute Renal Colic 收起 << | Phase 4 | Suspended(same study already p... 展开 >>ublished) 收起 << | March 2018 | France ... 展开 >> CH d'Alès Alès, France, 30103 CHU de Nîmes - Hôpital Universitaire Carémeau Nîmes Cedex 9, France, 30029 收起 << |
NCT01323998 | - | Completed | - | - | |
NCT01332487 | - | Completed | - | - | |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.35mL 0.47mL 0.23mL |
11.74mL 2.35mL 1.17mL |
23.48mL 4.70mL 2.35mL |
CAS号 | 81403-68-1 |
分子式 | C19H28ClN5O4 |
分子量 | 425.91 |
别名 | 阿夫唑嗪盐酸盐 ;SL 77499-10;Alfuzosin (hydrochloride);Uroxatral;SL 77499 HCl;Alfuzosin HCl |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,Room Temperature |
溶解度 |
DMSO: 25 mg/mL(58.7 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 50 mg/mL(117.4 mM),配合低频超声助溶 |
动物实验配方 |