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盐酸育亨宾 /Yohimbine HCI {[allProObj[0].p_purity_real_show]}

货号:A137676 同义名: Yohimbine (hydrochloride);Antagonil Ambeed 开学季,买赠积分,赢豪礼

Yohimbine HCl is naturall occuring alpha-2 adrenergic antagonist derived from the bark of the African tree Pausinystalia johimbe, used as a veterinary drug to reverse sedation in dogs and deer.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Yohimbine HCI 化学结构 CAS号:65-19-0
Yohimbine HCI 化学结构
CAS号:65-19-0
Yohimbine HCI 3D分子结构
CAS号:65-19-0
Yohimbine HCI 化学结构 CAS号:65-19-0
Yohimbine HCI 3D分子结构 CAS号:65-19-0
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Yohimbine HCI 纯度/质量文件 产品仅供科研

货号:A137676 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 Adrenergic Receptor α-adrenergic receptor β-adrenergic receptor 其他靶点 纯度
Ivabradine HCl {[allProObj[0].p_purity_real_show]}
Maprotiline hydrochloride {[allProObj[0].p_purity_real_show]}
Cisatracurium besylate {[allProObj[0].p_purity_real_show]}
Yohimbine HCI {[allProObj[0].p_purity_real_show]}
BMY 7378 ++

α2C-adrenoceptor, pKi: 6.54

α1D-adrenoceptor, pKi: 5.1

+

β1-adrenoceptor, pIC50: 5.1

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Asenapine maleate ++++

α2B-adrenergic receptor, pKi: 8.9

α2A-adrenergic receptor, pKi: 8.9

{[allProObj[0].p_purity_real_show]}
Piribedil ++

adrenoceptor α2C, pKi: 7.2

adrenoceptor α2A, pKi: 7.1

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Prazosin HCl {[allProObj[0].p_purity_real_show]}
Silodosin {[allProObj[0].p_purity_real_show]}
Phenoxybenzamine HCl {[allProObj[0].p_purity_real_show]}
Naftopidil +++

α1D-adrenergic receptor, Ki: 20 nM

α1A-adrenergic receptor, Ki: 3.7 nM

{[allProObj[0].p_purity_real_show]}
Naftopidil 2HCl +

α1-adrenergic receptor, IC50: 0.2 μM

{[allProObj[0].p_purity_real_show]}
Alfuzosin HCl {[allProObj[0].p_purity_real_show]}
Terazosin HCl {[allProObj[0].p_purity_real_show]}
Atipamezole {[allProObj[0].p_purity_real_show]}
Phentolamine methanesulfonate salt {[allProObj[0].p_purity_real_show]}
Doxazosin mesylate {[allProObj[0].p_purity_real_show]}
Tolazoline HCl {[allProObj[0].p_purity_real_show]}
Zenidolol hydrochloride ++++

β2-adrenergic receptor, Ki: 0.7nM

β1-adrenergic receptor, Ki: 611nM

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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Yohimbine HCI 生物活性

靶点
  • α-adrenergic receptor

描述 Yohimbine hydrochloride is an α2 adrenergic receptor inhibitor. It blocks the α2 adrenergic receptor before or after synapse and causes the release of noradrenaline and dopamine. In vivo, yohimbine hydrochloride (0.2 mg/kg, i.p.) injected to rats 1h before the stress session daily for 14 consecutive days significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats[3]. Moreover, increased noradrenergic activity after yohimbine administration and fear responses were higher after yohimbine as indicated by skin conductance responses and fear-potentiated startle responses[4].

Yohimbine HCI 参考文献

[1]Banihashemi L, Rinaman L. Noradrenergic inputs to the bed nucleus of the stria terminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine. J Neurosci. 2006 Nov 1;26(44):11442-53.

[2]Ernst E, Pittler MH. Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials. J Urol. 1998 Feb;159(2):433-6.

[3]Saad MA, Eid NI, Abd El-Latif HA, Sayed HM. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats. Eur J Pharmacol. 2013;700(1-3):127-133.

[4]Kuehl LK, Deuter CE, Hellmann-Regen J, Kaczmarczyk M, Otte C, Wingenfeld K. Enhanced noradrenergic activity by yohimbine and differential fear conditioning in patients with major depression with and without adverse childhood experiences. Prog Neuropsychopharmacol Biol Psychiatry. 2020;96:109751.

Yohimbine HCI 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.79mL

2.56mL

1.28mL

25.58mL

5.12mL

2.56mL

Yohimbine HCI 技术信息

CAS号65-19-0
分子式C21H27ClN2O3
分子量 390.904
别名 Yohimbine (hydrochloride);Antagonil;Dayto himbin;Yoman;Yovital;Yohimar;Thybine;Actibine;Yohimbic acid methyl ester;Johimbin;Aphrosol;Aphrodyne;(+)-Yohimbine;APHRODINE;Yocon;Yohimex;Quebrachine;Quebrachin;Corynine;Yohimbin;Yohimbine;Yohimbe;NSC 19509;NIH 9689;Yohimbine HCl
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 35 mg/mL(89.54 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 3 mg/mL(7.67 mM),配合低频超声助溶

动物实验配方
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