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抑制剂/激动剂
抗生素和抗病毒 肿瘤
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DNA损伤 细胞周期 结构 肿瘤表观遗传和基因调控
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DNA
安莎霉素类 Antibacterial
/ Rifaximin

利福昔明 /Rifaximin {[allProObj[0].p_purity_real_show]}

货号：A104206 同义名： L 105SV;Rifamycin L 105

Rifaximin is an RNA synthesis inhibitor by binding the β subunit of the bacterial DNA-dependent RNA polymerase, used to treat traveler's diarrhea caused by certain bacteria.

Rifaximin 化学结构 CAS号：80621-81-4
Rifaximin 化学结构
CAS号：80621-81-4
Rifaximin 3D分子结构
CAS号：80621-81-4
Rifaximin 化学结构 CAS号：80621-81-4
Rifaximin 3D分子结构 CAS号：80621-81-4
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Rifaximin 纯度/质量文件 产品仅供科研

货号：A104206 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLMfull-length, IC50: 2.98 μM

BLM636-1298, IC50: 0.97 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 97%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 97%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, IC50: 46.11 nM

Leucyl-tRNA synthetase, Kd: 42.1 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Rifaximin 生物活性

描述 Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. The use of rifaximin is associated with a low incidence of development, or persistence of spontaneous bacterial mutants[3]. Rifaximin is a broad-range, gastrointestinal-specific antibiotic. Rifaximin may be useful in the treatment of gastrointestinal disorders associated with altered bacterial flora, including irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO) [4]. Rifaximin has the potential advantage of preventing bacterial overgrowth and translocation without the systemic side effects of broad-spectrum antibiotics. Rifaximin may be effective in preventing SBP in patients with cirrhosis and ascites compared to systemically absorbed antibiotics and compared to placebo[5]. Rifaximin mitigates ascites and improves survival of cirrhotic patients with refractory ascites[6]. Moreover, combination of rifaximin and lactulose has beneficial effects on HE(hepatic encephalopathy). Compared with lactulose alone, additional rifaximin increases clinical efficacy and decreases mortality[7].

Rifaximin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03185611 Crohn Disease Phase 3 Recruiting July 31, 2018 China, Guangdong ... 展开 >> The Sixth Affiliated Hospital, Sun Yat-sen University Recruiting Guanzhou, Guangdong, China, 510000 Contact: Xiang Gao, MD, PhD    020-38663423    gaoxiangmed@163.com 收起 <<
NCT03219528 Irritable Bowel Syndrome Phase 4 Recruiting February 2020 United States, Michigan ... 展开 >> University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Deepa Chandhrasekhar          Contact: Amy Liu          Principal Investigator: Allen Lee 收起 <<
NCT01662791 Parkinson's Disease Phase 3 Completed - United States, Arizona ... 展开 >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 收起 <<

Rifaximin 参考文献

[1]Mencarelli A, Renga B, et al. Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells. Eur J Pharmacol. 2011 Oct 1;668(1-2):317-24.

[2]Adachi JA, DuPont HL. Rifaximin: a novel nonabsorbed rifamycin for gastrointestinal disorders. Clin Infect Dis. 2006 Feb 15;42(4):541-7.

[3]Shayto RH, Abou Mrad R, Sharara AI. Use of rifaximin in gastrointestinal and liver diseases. World J Gastroenterol. 2016 Aug 7;22(29):6638-51

[4]Pimentel M. Review of rifaximin as treatment for SIBO and IBS. Expert Opin Investig Drugs. 2009 Mar;18(3):349-58

[5]Goel A, Rahim U, Nguyen LH, Stave C, Nguyen MH. Systematic review with meta-analysis: rifaximin for the prophylaxis of spontaneous bacterial peritonitis. Aliment Pharmacol Ther. 2017 Dec;46(11-12):1029-1036

[6]Lv XY, Ding HG, Zheng JF, Fan CL, Li L. Rifaximin improves survival in cirrhotic patients with refractory ascites: A real-world study. World J Gastroenterol. 2020 Jan 14;26(2):199-218

[7]Wang Z, Chu P, Wang W. Combination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy. Drug Des Devel Ther. 2018 Dec 17;13:1-11

Rifaximin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.36mL

1.27mL

0.64mL

12.72mL

2.54mL

1.27mL

Rifaximin 技术信息

CAS号80621-81-4
分子式C43H51N3O11
分子量 785.88
别名 L 105SV;Rifamycin L 105;trade names: RCIFAX, Rifagut, Xifaxan, Zaxine;Ritacol;Rifaxin;Rifaxidin;Rifacol;Normix;Fatroximin;L105;BRN 3584528
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 50 mg/mL(63.62 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

PO 5%DMSO + 30%PEG400 + 2%Tween80 + water 5 mg/mL clear

Tags: Rifaximin | L 105SV;Rifamycin L 105;trade names: RCIFAX, Rifagut, Xifaxan, Zaxine;Ritacol;Rifaxin;Rifaxidin;Rifacol;Normix;Fatroximin;L105;BRN 3584528 | Ansamycin | DNA/RNA Synthesis | Antibacterial | AmBeed-信号通路专用抑制剂 | Rifaximin 纯度/质量文件 | Rifaximin 亚型比较 | Rifaximin 生物活性 | Rifaximin 临床数据 | Rifaximin 参考文献 | Rifaximin 实验方案 | Rifaximin 技术信息

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