Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[3]. Psoralen may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice[4]. When the rats were pretreated with psoralen (20 mg/kg/day for 10 days), the system exposure of anastrozole would be increased significantly[5]. The acute oral median lethal dose of psoralen in ICR mice was determined to be 1,673 mg/kg. Psoralen inhibited the viability of normal human liver L02 cells in vitro by inducing S-phase arrest. In addition, psoralen in both the mouse livers and L02 cells upregulated cyclin E1 and p27 protein levels[6]. Psoralen could induce hepatotoxicity by enhanced liver-to-body weight ratio and alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total cholesterol after administration for 3 days. In addition, histopathological examinations also indicated the hepatotoxicity induced by psoralen[7]. Chronic exposure to low-level of psoralen causes a disturbance in alanine metabolism, glutamate metabolism, urea cycle, glucose-alanine cycle, ammonia recycling, glycine, and serine metabolism pathways[8].
Psoralen 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
HCT116 cells
Cytotoxicity assay
96 h
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay, IC50=45.6 μM
23746477
HL-60
Cytotoxicity assay
Cytotoxicity against HL-60 (human fibrosarcoma) cell line; Range 0.4-16 uM, IC50=16 μM
15837311
HT-29 cells
Cytotoxicity assay
96 h
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay, IC50=41.7 μM
23746477
LoVo
Cytotoxicity assay
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line; Range 0.4-16 uM, IC50=16 μM
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