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Psoralen

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Chemical Structure| 66-97-7 同义名 : Ficusin;Furocoumarin;7H-Furo[3,2-g]chromen-7-one;66-97-7;NSC 404562;Psoralene
CAS号 : 66-97-7
货号 : A232760
分子式 : C11H6O3
纯度 : 98+%
分子量 : 186.163
MDL号 : MFCD00010520
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(564.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Psoralen, an ingredient from Fructus Psoraleae, intercalates with DNA, inhibiting DNA synthesis and cell division and showing anticancer activity. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[3]. Psoralen may function to inhibit breast cancer cell growth in the bone microenvironment and regulate the function of osteoblasts and osteoclasts in tumor-bearing mice[4]. When the rats were pretreated with psoralen (20 mg/kg/day for 10 days), the system exposure of anastrozole would be increased significantly[5]. The acute oral median lethal dose of psoralen in ICR mice was determined to be 1,673 mg/kg. Psoralen inhibited the viability of normal human liver L02 cells in vitro by inducing S-phase arrest. In addition, psoralen in both the mouse livers and L02 cells upregulated cyclin E1 and p27 protein levels[6]. Psoralen could induce hepatotoxicity by enhanced liver-to-body weight ratio and alterations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total cholesterol after administration for 3 days. In addition, histopathological examinations also indicated the hepatotoxicity induced by psoralen[7]. Chronic exposure to low-level of psoralen causes a disturbance in alanine metabolism, glutamate metabolism, urea cycle, glucose-alanine cycle, ammonia recycling, glycine, and serine metabolism pathways[8].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
HCT116 cells Cytotoxicity assay 96 h Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay, IC50=45.6 μM 23746477
HL-60 Cytotoxicity assay Cytotoxicity against HL-60 (human fibrosarcoma) cell line; Range 0.4-16 uM, IC50=16 μM 15837311
HT-29 cells Cytotoxicity assay 96 h Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay, IC50=41.7 μM 23746477
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.37mL

1.07mL

0.54mL

26.86mL

5.37mL

2.69mL

53.72mL

10.74mL

5.37mL
参考文献

[1]Wang X, Cheng K, et al. Effects of Psoralen as an Anti-tumor Agent in Human Breast Cancer MCF-7/ADR Cells. Biol Pharm Bull. 2016 May 1;39(5):815-22.

[2]Hsieh MJ, Chen MK, et al. Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines. Phytomedicine. 2014 Jun 15;21(7):970-7.

[3]Yin L, Pang G, Niu C, Habasi M, Dou J, Aisa HA. A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells. Int J Mol Med. 2018 Jun;41(6):3727-3735

[4]Wu C, Sun Z, Ye Y, Han X, Song X, Liu S. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-210

[5]Zhang Y, Wu J, Zhou Y, Yin Y, Chen H. Effects of psoralen on the pharmacokinetics of anastrozole in rats. Pharm Biol. 2018 Dec;56(1):433-439

[6]Zhou W, Chen X, Zhao G, Xu D, Jiang Z, Zhang L, Wang T. Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability. Front Pharmacol. 2018 Oct 22;9:1179

[7]Huang J, Wang Q, Chen M, Bi Y, Shi H, Zhou K. Effects of psoralen on hepatic bile acid transporters in rats. Hum Exp Toxicol. 2021 Jun;40(6):1012-1021

[8]Yu Y, Wang P, Yu R, Lu J, Jiang M, Zhou K. Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes in Female Rats. Metabolites. 2019 Nov 2;9(11):263