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Polyinosinic-polycytidylic acid sodium
聚肌苷酸-聚胞苷酸钠盐 /Polyinosinic-polycytidylic acid sodium
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货号：A666696
同义名：
双链聚肌胞
/ Poly(I:C) sodium
聚肌胞酸钠 (Poly(I)) 是一种双链 RNA 的合成类似物，作为 Toll 样受体 3 (TLR3) 和视黄酸诱导基因 I (RIG-I) 受体 (MDA5) 的激动剂。聚肌胞酸钠可作为疫苗佐剂增强先天和适应性免疫反应，改变肿瘤微环境，并直接诱导癌细胞凋亡。
Polyinosinic-polycytidylic acid sodium 化学结构
CAS号：42424-50-0
Polyinosinic-polycytidylic acid sodium 3D分子结构
CAS号：42424-50-0
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Polyinosinic-polycytidylic acid sodium 纯度/质量文件 产品仅供科研
货号：A666696
标准纯度：
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Polyinosinic-polycytidylic acid sodium 质控信息
| Desvenlafaxine |
++
|
|
|
|
|
|
|
|
98% |
| Lamotrigine |
+
5-HT (rat brain synaptosomes), IC50: 474 μM
5-HT (human platelets), IC50: 240 μM
|
|
|
|
|
|
|
|
98% |
| Venlafaxine |
✔
|
|
|
|
|
|
|
|
98% |
| Fluvoxamine maleate |
✔
|
|
|
|
|
|
|
|
99% |
| Iloperidone |
✔
|
|
|
|
|
|
|
|
98% |
| Ziprasidone HCl |
✔
|
|
|
|
|
|
|
|
98+% |
| Atomoxetine HCI |
+
|
|
|
|
|
|
|
|
98% |
| Dapoxetine HCl |
✔
|
|
|
|
|
|
|
|
97% |
| Trazodone |
✔
|
|
|
|
|
|
|
|
98+% |
| Clomipramine HCl |
✔
|
|
|
|
|
|
|
|
98% |
| Mirtazapine |
✔
|
|
|
|
|
|
|
|
99+% |
| Escitalopram oxalate |
+++
|
|
|
|
|
|
|
|
97% |
| Duloxetine |
✔
|
|
|
|
|
|
|
|
98+% |
| Sertraline HCl |
++
|
|
|
|
|
|
|
|
98% |
| Citalopram HBr |
+++
serotonin reuptake, IC50: 1.8 nM
|
|
|
|
|
|
|
|
98% |
| Latrepirdine 2HCl |
✔
|
|
|
|
|
|
|
GluR
|
98% |
| Fluoxetine HCl |
✔
|
|
|
|
|
|
|
|
99.5% |
| Paroxetine hydrochloride |
✔
|
|
|
|
|
|
|
AChR
|
97% |
| BMY 7378 |
|
++
5-HT1A, pIC50: 6.4
5-HT1D, pIC50: 5.9
|
+
|
|
|
|
|
|
97% |
| Flibanserin |
|
+++
|
+
|
|
|
|
|
|
98% |
| LY310762 |
|
+
|
|
|
|
|
|
|
99%+ |
| Cyclobenzaprine HCI |
|
|
✔
|
|
|
|
|
|
99% |
| Blonanserin |
|
|
+++
|
|
|
|
|
|
98% HPLC |
| Cyproheptadine HCl |
|
|
++++
|
|
|
|
|
|
99+% |
| Olanzapine |
|
|
✔
|
|
|
|
|
|
99+% |
| Pimavanserin hemitartrate |
|
|
+++
|
|
|
|
|
|
99% |
| Ketanserin |
|
|
+++
5-HT2C (Rat), Ki: 50 nM
5-HT2C (Human), Ki: 2.5 nM
|
|
|
|
|
|
99%+ |
| Loxapine succinate |
|
|
++
5-HT2 (human), Ki: 6.8 nM
5-HT2 (bovine), Ki: 6.6 nM
|
|
|
|
|
|
99% |
| Agomelatine |
|
|
✔
|
|
|
|
|
|
98% |
| Clozapine |
|
|
✔
|
|
|
|
|
|
98% |
| Amitriptyline |
|
|
+
|
|
|
|
|
SERT
|
98% |
| PRX-08066 maleate |
|
|
+++
|
|
|
|
|
|
98+% |
| RS-127445 |
|
|
++++
5-HT2B, pIC50: 10.4
5-HT2B, pKi: 9.5
|
|
|
|
|
|
99%+ |
| Sarpogrelate HCl |
|
|
++++
5-HT2C, Kd: 1.1 nM
5-HT2A, Kd: 2.1 nM
|
|
|
|
|
|
98% |
| Tropisetron |
|
|
|
✔
|
|
|
|
|
99% |
| Palonosetron |
|
|
|
✔
|
|
|
|
|
98+% |
| Ramosetron HCl |
|
|
|
++++
5-HT3 receptor, Ki: 0.091 nM
|
|
|
|
|
98% |
| Ondansetron |
|
|
|
✔
|
|
|
|
|
99% |
| Granisetron |
|
|
|
✔
|
|
|
|
|
98% |
| Alosetron HCl |
|
|
|
✔
|
|
|
|
|
98% |
| Ondansetron hydrochloride dihydrate |
|
|
|
✔
|
|
|
|
|
98% |
| VUF10166 |
|
|
|
++++
5-HT3A, Ki: 0.04 nM
5-HT3AB, Ki: 22 nM
|
|
|
|
|
99%+ |
| Azasetron hydrochloride |
|
|
|
++++
|
|
|
|
|
98% |
| Asenapine maleate |
|
+++
5-HT1A, pKi: 8.6
5-HT1B, pKi: 8.4
|
++++
5-HT2A, pKi: 9.75
5-HT2C, pKi: 10.46
|
|
+++
|
++++
|
++++
|
|
97% |
| Risperidone |
|
++
5-HT1B, Ki: 14.9 nM
5-HT1D, Ki: 84.6 nM
|
++++
5-HT2A, Ki: 61.9 nM
5-HT2C, Ki: 12 nM
|
|
+
|
|
++
|
|
98% |
| SB 271046 HCl |
|
|
|
|
|
+++
|
|
|
99%+ |
| Intepirdine |
|
|
|
|
|
++++
|
|
|
99%+ |
| SB-269970 HCl |
|
|
|
|
|
|
++
|
|
98+% |
| BRL 15572 |
|
++
5-HT1D, pKi: 6
5-HT1B, pKi: 6.1
|
++
5-HT2B, pKi: 6.2
5-HT2A, pKi: 6.6
|
|
|
+
|
+
|
|
98% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
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Polyinosinic-polycytidylic acid sodium 技术信息
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