Oxomemazine | Histamine H1-receptor Blocker | AmBeed-信号通路专用抑制剂

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Oxomemazine {[allProObj[0].p_purity_real_show]}

货号：A484536

Oxomemazine是一种基于吩噻嗪的组胺 H1 受体 (histamine H1-receptor) 阻滞剂，具有明显的抗毒蕈碱活性，并作为毒菌碱 M1 受体的选择性拮抗剂，在高 (histamine H1-receptor=84 nM, M1受体) 和低 (histamine H1-receptor=1.65 μM, M2受体) 亲和力位点上显示了 20 倍的差异，可用于咳嗽相关研究的抗组胺和抗胆碱能试剂。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Oxomemazine 化学结构
CAS号：3689-50-7

Oxomemazine 3D分子结构
CAS号：3689-50-7

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Oxomemazine 纯度/质量文件产品仅供科研

货号：A484536 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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组胺受体亚型比较

产品名称	H1 receptor ↓ ↑	H2 receptor ↓ ↑	H3 receptor ↓ ↑	H4 receptor ↓ ↑	Histamine receptor ↓ ↑	其他靶点	纯度
Hydroxyzine 2HCl							99+%
Cyclizine	✔						97%
Loratadine	+ B(0)AT2, IC50: 4 μM						98%
Desloratadine	++ Histamine H1 receptor, IC50: 51 nM						98%
Doxylamine succinate	✔						99%
Ebastine	✔						98%
Tripelennamine HCl	+ H1 receptor, IC50: 30 μM						98%
Meclizine dihydrochloride	✔						98%
Chlorpheniramine maleate	+++ Histamine H1 receptor, IC50: 12 nM						99%
Diphenhydramine HCl	✔						99%
Alcaftadine	++++ H1 receptor, pKi: 8.5	++ H2 receptor, pKi: 7.2					99%+
Fexofenadine HCl	++ Histamine H1 receptor, IC50: 246 nM						99%+
Bilastine	+++ H1 receptor, Ki: 44.15 nM						98%
Pemirolast potassium	✔						98%
Bepotastine besilate	+ Histamine H1 receptor, pIC50: 5.7						98%
Mizolastine	+++ Histamine H1 receptor, IC50: 47 nM						98%
Brompheniramine maleate	✔						98%
Carbinoxamine maleate salt	✔						99+%
Clemastine fumarate	++++ Histamine H1 receptor, IC50: 3 nM						98%
Ketotifen fumarate salt	✔						95%
Rupatadine Fumarate	++ Histamine H1 receptor, Ki: 102 nM					PAFR	98%
Famotidine		✔					97%
Roxatidine Acetate HCl		+ Histamine H2 receptor, IC50: 3.2 μM					98%
Lafutidine		✔					99%
Cimetidine		✔					98%
Nizatidine		++++ Histamine H2 receptor, IC50: 0.9 nM				AChE	98%
Ranitidine		✔					99%
Betahistine			+ Histamine H3 receptor, IC50: 1.9 μM				98%
Ciproxifan maleate			+++ Histamine H3 receptor, IC50: 9.2 nM				99%+
S 38093			++ rat H3 receptor, Ki: 1.44 μM human H3 receptor, Ki: 1.2 μM				98%
JNJ-7777120				++++ Histamine H4 receptor, Ki: 4.5 nM			98%
Azelastine HCl					✔		98%
Epinastine HCl					✔		98%
Levodropropizine					✔		97%
Cyproheptadine hydrochloride					✔		98%
Hesperetin					✔		97%
Olopatadine HCl					✔		98%
Mianserin hydrochloride					✔		99+%
Buclizine 2HCl					✔		97%
Latrepirdine 2HCl					✔	GluR	98%
Cetirizine 2HCl					✔		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Oxomemazine 生物活性

描述

Oxomemazine, a phenothiazine-based histamine H1-receptor antagonist, exhibits significant antimuscarinic effects. It acts as a selective antagonist for the muscarinic M1 receptor, demonstrating approximately a 20-fold difference in affinity between high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites^[1]. Oxomemazine, an antihistamine and anticholinergic agent, is employed for researching cough treatment^[2].

Oxomemazine 参考文献

[1]S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptorsArch Pharm Res. 1994 Dec;17(6):443-51.

[2]M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67(Pt 8):o1875.

Oxomemazine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL

Oxomemazine 技术信息

CAS号	3689-50-7
分子式	C₁₈H₂₂N₂O₂S
分子量	330.445

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(317.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

Oxomemazine {[allProObj[0].p_purity_real_show]}

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Oxomemazine {[allProObj[0].p_purity_real_show]}

Oxomemazine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Oxomemazine 质控信息

Oxomemazine 生物活性

Oxomemazine 参考文献

Oxomemazine 实验方案

Oxomemazine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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C

F

G

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Oxomemazine 纯度/质量文件产品仅供科研