JC-1 (CBIC2) serves as an ideal fluorescent probe for detecting mitochondrial membrane potential, accumulating in mitochondria in a potential-dependent manner. It can be used to assess the membrane potential of cells, tissues, or purified mitochondria. In healthy mitochondria, JC-1 aggregates in the mitochondrial matrix, forming a polymer that emits strong red fluorescence; when mitochondrial membrane potential decreases, JC-1 cannot aggregate, producing green fluorescence instead[1].
体外研究
JC-1 (CBIC2) serves as an ideal fluorescent probe for detecting mitochondrial membrane potential, accumulating in mitochondria in a potential-dependent manner. It can be used to assess the membrane potential of cells, tissues, or purified mitochondria. In healthy mitochondria, JC-1 aggregates in the mitochondrial matrix, forming a polymer that emits strong red fluorescence; when mitochondrial membrane potential decreases, JC-1 cannot aggregate, producing green fluorescence instead[1].
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