There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Lodoxamide blocks histamine release induced by compound 48/80 and inhibits ionophore-induced 45Ca influx along with associated histamine release in purified rat peritoneal mast cells[1]. Lodoxamide significantly and dose-dependently reduces the chemotactic response of eosinophils to fMLP and IL-5. It also strongly inhibits the release of eosinophil peroxidase following IgA-dependent activation and, to a lesser extent, inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin[2].
体内研究
Lodoxamide exhibits cromolyn-like effects in rat peritoneal mast cell assay (PCA) models and in Ascaris antigen-sensitized anesthetized rhesus monkeys. When administered intravenously, orally, or by aerosol intrabronchially, lodoxamide significantly mitigates the increased respiratory rate and reduced tidal volume triggered by antigen exposure in these monkeys[1].
Adding lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution significantly reduces lung reperfusion injury, evidenced by improved oxygenation, reduced microvascular permeability, and enhanced compliance[3].
Patients receiving lodoxamide tromethamine show improvements in daytime breathing difficulties, cough, sputum production, and sleep[4].
体外研究
Lodoxamide blocks histamine release induced by compound 48/80 and inhibits ionophore-induced 45Ca influx along with associated histamine release in purified rat peritoneal mast cells[1].
Lodoxamide significantly and dose-dependently reduces the chemotactic response of eosinophils to fMLP and IL-5. It also strongly inhibits the release of eosinophil peroxidase following IgA-dependent activation and, to a lesser extent, inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin[2].
搜索
HazMat Fee +
