LDCA是一种双重作用的代谢调节剂，能够抑制乳酸脱氢酶 A (LDH-A) 活性并促进恶性细胞凋亡，广泛应用于癌症进展的研究中。
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HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
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Accessible (Haz class 3, 4, 5 or 8), International
LDCA acts as a dual-hit metabolic modulator, inhibiting LDH-A enzyme activity to promote apoptosis in cancer cells. It is used in cancer progression research[1].
体内研究
LDCA (2 mg/kg, intravenously, on the 6th day, once) combined with doxorubicin effectively impedes tumor growth kinetics, curbing oncogenic progression and enhancing survival in a murine melanoma model[1].
体外研究
LDCA, when used synergistically with doxorubicin in concentrations of 2-100 μM over 16-72 hours, enhances growth inhibition and triggers mitochondria-mediated apoptosis. This combination recruits the caspase cascade, limits cell migration, and prevents clonogenic expansion of melanoma cells[1].
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