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LDCA

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Chemical Structure| 349106-80-5 同义名 : -
CAS号 : 349106-80-5
货号 : A1680546
分子式 : C8H5Cl3FNO
纯度 : 99%+
分子量 : 256.489
MDL号 : -
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(409.37 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LDCA acts as a dual-hit metabolic modulator, inhibiting LDH-A enzyme activity to promote apoptosis in cancer cells. It is used in cancer progression research[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.90mL

0.78mL

0.39mL

19.49mL

3.90mL

1.95mL

38.99mL

7.80mL

3.90mL
参考文献

[1]Saha, Suchandrima, et al. The dual-hit metabolic modulator LDCA synergistically potentiates doxorubicin to selectively combat cancer-associated hallmarks. RSC Advances, 7(84), 53322–53333. doi:10.1039/c7ra08625c.

[2]Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8.