FEN1-IN-3 | FEN1 Inhibitor C3 | FEN1 Inhibitor | AmBeed-信号通路专用抑制剂

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FEN1-IN-3 {[allProObj[0].p_purity_real_show]}

货号：A605561 同义名： FEN1 Inhibitor C3

FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage.

FEN1-IN-3 化学结构
CAS号：2109805-87-8

FEN1-IN-3 3D分子结构
CAS号：2109805-87-8

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FEN1-IN-3 纯度/质量文件产品仅供科研

货号：A605561 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^636-1298, IC50: 0.97 μM BLM^full-length, IC50: 2.98 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					97%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				97%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, IC50: 46.11 nM Leucyl-tRNA synthetase, Kd: 42.1 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

FEN1-IN-3 生物活性

描述

The structure-selective human flap endonuclease-1 (FEN1) is a metallonuclease that plays a key role in DNA replication and genome maintenance. Human FEN1 is overexpressed in multiple cancer types and therefore has been suggested as an oncology target. FEN1 inhibitor C3 stabilizes human FEN1 with an EC50 value of 6.8μM in an isothermal concentration-response experiment. FEN1 inhibitor C3 inhibits human FEN1-336Δ with an IC50 value of 16.9±1.2nM. It also exhibited cytotoxic against HeLa cells with an EC50 value of 6μM^[2].

FEN1-IN-3 参考文献

[1]Ward TA, McHugh PJ, Durant ST. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12(6):e0179278.

[2]Exell JC, Thompson MJ, Finger LD, et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016;12(10):815-821.

FEN1-IN-3 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL

FEN1-IN-3 技术信息

CAS号	2109805-87-8
分子式	C₁₅H₁₂N₂O₄
分子量	284.267

别名	FEN1 Inhibitor C3
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 250 mg/mL(879.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

FEN1-IN-3 {[allProObj[0].p_purity_real_show]}

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FEN1-IN-3 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

FEN1-IN-3 质控信息

FEN1-IN-3 生物活性

FEN1-IN-3 参考文献

FEN1-IN-3 实验方案

FEN1-IN-3 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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FEN1-IN-3 纯度/质量文件产品仅供科研