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FEN1-IN-3

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Chemical Structure| 2109805-87-8 同义名 : FEN1 Inhibitor C3
CAS号 : 2109805-87-8
货号 : A605561
分子式 : C15H12N2O4
纯度 : 99%+
分子量 : 284.267
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(879.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The structure-selective human flap endonuclease-1 (FEN1) is a metallonuclease that plays a key role in DNA replication and genome maintenance. Human FEN1 is overexpressed in multiple cancer types and therefore has been suggested as an oncology target. FEN1 inhibitor C3 stabilizes human FEN1 with an EC50 value of 6.8μM in an isothermal concentration-response experiment. FEN1 inhibitor C3 inhibits human FEN1-336Δ with an IC50 value of 16.9±1.2nM. It also exhibited cytotoxic against HeLa cells with an EC50 value of 6μM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL
参考文献

[1]Ward TA, McHugh PJ, Durant ST. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12(6):e0179278.

[2]Exell JC, Thompson MJ, Finger LD, et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016;12(10):815-821.